Skip to main content
Top
Published in: Malaria Journal 1/2012

Open Access 01-12-2012 | Research

Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria

Authors: Ville Holmberg, Päivi Onkamo, Elisa Lahtela, Päivi Lahermo, George Bedu-Addo, Frank P Mockenhaupt, Seppo Meri

Published in: Malaria Journal | Issue 1/2012

Login to get access

Abstract

Background

Innate immunity plays a crucial role in the host defense against malaria including Plasmodium falciparum malaria in pregnancy, but the roles of the various underlying genes and mechanisms predisposing to the disease are poorly understood.

Methods

98 single-nucletoide polymorphisms were genotyped in a set of 17 functionally related genes of the complement system in 145 primiparous Ghanaian women with placental malaria, defined by placental parasitaemia or malaria pigment, and as a control, in 124 non-affected primiparae.

Results

Placental malaria was significantly associated with SNPs in the lectin pathway genes MBL2, MASP2, FCN2 and in properdin. In particular, the main African mannose-binding lectin deficiency variant (MBL2* G57E, rs1800451) increased the odds of placental malaria (OR 1.6; permuted p-value 0.014). In contrast, a common MASP2 mutation (R439H, rs12085877), which reduces the activity of MBL-MASP2 complexes occurred in 33% of non-affected women and in 22% primiparae with placental malaria (OR 0.55, permuted p-value 0.020).

Conclusions

Excessive complement activation is of importance in the pathogenesis of placental malaria by mediating inflammation, coagulation, and endothelial dysfunction. Mutated MBL and MASP2 proteins could have direct intrinsic effects on the susceptibility to placental malaria, in addition to their roles in regulation of downstream complement activation.
Appendix
Available only for authorised users
Literature
1.
go back to reference Desai M, ter Kuile FO, Nosten F, McGready R, Asamoa K, Brabin B, Newman RD: Epidemiology and burden of malaria in pregnancy. Lancet Infect Dis. 2007, 7: 93-104. 10.1016/S1473-3099(07)70021-X.CrossRefPubMed Desai M, ter Kuile FO, Nosten F, McGready R, Asamoa K, Brabin B, Newman RD: Epidemiology and burden of malaria in pregnancy. Lancet Infect Dis. 2007, 7: 93-104. 10.1016/S1473-3099(07)70021-X.CrossRefPubMed
2.
go back to reference Duffy PE: Plasmodium in the placenta: parasites, parity, protection, prevention and possibly preeclampsia. Parasitology. 2007, 134: 1877-1881.CrossRefPubMed Duffy PE: Plasmodium in the placenta: parasites, parity, protection, prevention and possibly preeclampsia. Parasitology. 2007, 134: 1877-1881.CrossRefPubMed
3.
go back to reference Dellicour S, Tatem AJ, Guerra CA, Snow RW, Ter Kuile FO: Quantifying the number of pregnancies at risk of malaria in 2007: a demographic study. PLoS Med. 2010, 7: e1000221-10.1371/journal.pmed.1000221.PubMedCentralCrossRefPubMed Dellicour S, Tatem AJ, Guerra CA, Snow RW, Ter Kuile FO: Quantifying the number of pregnancies at risk of malaria in 2007: a demographic study. PLoS Med. 2010, 7: e1000221-10.1371/journal.pmed.1000221.PubMedCentralCrossRefPubMed
4.
go back to reference Fried M, Muga RO, Misore AO, Duffy PE: Malaria elicits type 1 cytokines in the human placenta: IFN-gamma and TNF-alpha associated with pregnancy outcomes. J Immunol. 1998, 160: 2523-2530.PubMed Fried M, Muga RO, Misore AO, Duffy PE: Malaria elicits type 1 cytokines in the human placenta: IFN-gamma and TNF-alpha associated with pregnancy outcomes. J Immunol. 1998, 160: 2523-2530.PubMed
5.
go back to reference Moormann AM, Sullivan AD, Rochford RA, Chensue SW, Bock PJ, Nyirenda T, Meshnick SR: Malaria and pregnancy: placental cytokine expression and its relationship to intrauterine growth retardation. J Infect Dis. 1999, 180: 1987-1993. 10.1086/315135.CrossRefPubMed Moormann AM, Sullivan AD, Rochford RA, Chensue SW, Bock PJ, Nyirenda T, Meshnick SR: Malaria and pregnancy: placental cytokine expression and its relationship to intrauterine growth retardation. J Infect Dis. 1999, 180: 1987-1993. 10.1086/315135.CrossRefPubMed
6.
go back to reference Fried M, Nosten F, Brockman A, Brabin BJ, Duffy PE: Maternal antibodies block malaria. Nature. 1998, 395: 851-852. 10.1038/27570.CrossRefPubMed Fried M, Nosten F, Brockman A, Brabin BJ, Duffy PE: Maternal antibodies block malaria. Nature. 1998, 395: 851-852. 10.1038/27570.CrossRefPubMed
7.
go back to reference Duffy PE, Fried M: Antibodies that inhibit Plasmodium falciparum adhesion to chondroitin sulfate A are associated with increased birth weight and the gestational age of newborns. Infect Immun. 2003, 71: 6620-6623. 10.1128/IAI.71.11.6620-6623.2003.PubMedCentralCrossRefPubMed Duffy PE, Fried M: Antibodies that inhibit Plasmodium falciparum adhesion to chondroitin sulfate A are associated with increased birth weight and the gestational age of newborns. Infect Immun. 2003, 71: 6620-6623. 10.1128/IAI.71.11.6620-6623.2003.PubMedCentralCrossRefPubMed
8.
go back to reference Brabin BJ, Romagosa C, Abdelgalil S, Menendez C, Verhoeff FH, McGready R, Fletcher KA, Owens S, D'Alessandro U, Nosten F, Fischer PR, Ordi J: The sick placenta-the role of malaria. Placenta. 2004, 25: 359-378. 10.1016/j.placenta.2003.10.019.CrossRefPubMed Brabin BJ, Romagosa C, Abdelgalil S, Menendez C, Verhoeff FH, McGready R, Fletcher KA, Owens S, D'Alessandro U, Nosten F, Fischer PR, Ordi J: The sick placenta-the role of malaria. Placenta. 2004, 25: 359-378. 10.1016/j.placenta.2003.10.019.CrossRefPubMed
9.
go back to reference Moormann AM: How might infant and paediatric immune responses influence malaria vaccine efficacy?. Parasite Immunol. 2009, 31: 547-559. 10.1111/j.1365-3024.2009.01137.x.PubMedCentralCrossRefPubMed Moormann AM: How might infant and paediatric immune responses influence malaria vaccine efficacy?. Parasite Immunol. 2009, 31: 547-559. 10.1111/j.1365-3024.2009.01137.x.PubMedCentralCrossRefPubMed
10.
go back to reference Gowda DC: TLR-mediated cell signaling by malaria GPIs. Trends Parasitol. 2007, 23: 596-604. 10.1016/j.pt.2007.09.003.CrossRefPubMed Gowda DC: TLR-mediated cell signaling by malaria GPIs. Trends Parasitol. 2007, 23: 596-604. 10.1016/j.pt.2007.09.003.CrossRefPubMed
11.
go back to reference Mockenhaupt FP, Hamann L, von Gaertner C, Bedu-Addo G, von Kleinsorgen C, Schumann RR, Bienzle U: Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy. J Infect Dis. 2006, 194: 184-188. 10.1086/505152.CrossRefPubMed Mockenhaupt FP, Hamann L, von Gaertner C, Bedu-Addo G, von Kleinsorgen C, Schumann RR, Bienzle U: Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy. J Infect Dis. 2006, 194: 184-188. 10.1086/505152.CrossRefPubMed
12.
go back to reference Hamann L, Bedu-Addo G, Eggelte TA, Schumann RR, Mockenhaupt FP: The toll-like receptor 1 variant S248N influences placental malaria. Infect Genet Evol. 2010, 10: 785-789. 10.1016/j.meegid.2010.05.005.CrossRefPubMed Hamann L, Bedu-Addo G, Eggelte TA, Schumann RR, Mockenhaupt FP: The toll-like receptor 1 variant S248N influences placental malaria. Infect Genet Evol. 2010, 10: 785-789. 10.1016/j.meegid.2010.05.005.CrossRefPubMed
13.
go back to reference Sikora M, Ferrer-Admetlla A, Laayouni H, Menendez C, Mayor A, Bardaji A, Sigauque B, Mandomando I, Alonso PL, Bertranpetit J, Casals F: A variant in the gene FUT9 is associated with susceptibility to placental malaria infection. Hum Mol Genet. 2009, 18: 3136-3144. 10.1093/hmg/ddp240.CrossRefPubMed Sikora M, Ferrer-Admetlla A, Laayouni H, Menendez C, Mayor A, Bardaji A, Sigauque B, Mandomando I, Alonso PL, Bertranpetit J, Casals F: A variant in the gene FUT9 is associated with susceptibility to placental malaria infection. Hum Mol Genet. 2009, 18: 3136-3144. 10.1093/hmg/ddp240.CrossRefPubMed
14.
go back to reference Wallis R, Dodds AW, Mitchell DA, Sim RB, Reid KB, Schwaeble WJ: Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway. J Biol Chem. 2007, 282: 7844-7851. 10.1074/jbc.M606326200.CrossRefPubMed Wallis R, Dodds AW, Mitchell DA, Sim RB, Reid KB, Schwaeble WJ: Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway. J Biol Chem. 2007, 282: 7844-7851. 10.1074/jbc.M606326200.CrossRefPubMed
15.
go back to reference Thiel S: Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Mol Immunol. 2007, 44: 3875-3888. 10.1016/j.molimm.2007.06.005.CrossRefPubMed Thiel S: Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Mol Immunol. 2007, 44: 3875-3888. 10.1016/j.molimm.2007.06.005.CrossRefPubMed
16.
go back to reference Takahashi M, Ishida Y, Iwaki D, Kanno K, Suzuki T, Endo Y, Homma Y, Fujita T: Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D. J Exp Med. 2010, 207: 29-37. 10.1084/jem.20090633.PubMedCentralCrossRefPubMed Takahashi M, Ishida Y, Iwaki D, Kanno K, Suzuki T, Endo Y, Homma Y, Fujita T: Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D. J Exp Med. 2010, 207: 29-37. 10.1084/jem.20090633.PubMedCentralCrossRefPubMed
17.
go back to reference Klabunde J, Uhlemann AC, Tebo AE, Kimmel J, Schwarz RT, Kremsner PG, Kun JF: Recognition of Plasmodium falciparum proteins by mannan-binding lectin, a component of the human innate immune system. Parasitol Res. 2002, 88: 113-117.CrossRefPubMed Klabunde J, Uhlemann AC, Tebo AE, Kimmel J, Schwarz RT, Kremsner PG, Kun JF: Recognition of Plasmodium falciparum proteins by mannan-binding lectin, a component of the human innate immune system. Parasitol Res. 2002, 88: 113-117.CrossRefPubMed
18.
go back to reference Bellamy R, Ruwende C, McAdam KP, Thursz M, Sumiya M, Summerfield J, Gilbert SC, Corrah T, Kwiatkowski D, Whittle HC, Hill AV: Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans. QJM. 1998, 91: 13-18. 10.1093/qjmed/91.1.13.CrossRefPubMed Bellamy R, Ruwende C, McAdam KP, Thursz M, Sumiya M, Summerfield J, Gilbert SC, Corrah T, Kwiatkowski D, Whittle HC, Hill AV: Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans. QJM. 1998, 91: 13-18. 10.1093/qjmed/91.1.13.CrossRefPubMed
19.
go back to reference Luty AJ, Kun JF, Kremsner PG: Mannose-binding lectin plasma levels and gene polymorphisms in Plasmodium falciparum malaria. J Infect Dis. 1998, 178: 1221-1224. 10.1086/515690.CrossRefPubMed Luty AJ, Kun JF, Kremsner PG: Mannose-binding lectin plasma levels and gene polymorphisms in Plasmodium falciparum malaria. J Infect Dis. 1998, 178: 1221-1224. 10.1086/515690.CrossRefPubMed
20.
go back to reference Mombo LE, Ntoumi F, Bisseye C, Ossari S, Lu CY, Nagel RL, Krishnamoorthy R: Human genetic polymorphisms and asymptomatic Plasmodium falciparum malaria in Gabonese schoolchildren. AmJTrop Med Hyg. 2003, 68: 186-190. Mombo LE, Ntoumi F, Bisseye C, Ossari S, Lu CY, Nagel RL, Krishnamoorthy R: Human genetic polymorphisms and asymptomatic Plasmodium falciparum malaria in Gabonese schoolchildren. AmJTrop Med Hyg. 2003, 68: 186-190.
21.
go back to reference Boldt AB, Luty A, Grobusch MP, Dietz K, Dzeing A, Kombila M, Kremsner PG, Kun JF: Association of a new mannose-binding lectin variant with severe malaria in Gabonese children. Genes Immun. 2006, 7: 393-400. 10.1038/sj.gene.6364312.CrossRefPubMed Boldt AB, Luty A, Grobusch MP, Dietz K, Dzeing A, Kombila M, Kremsner PG, Kun JF: Association of a new mannose-binding lectin variant with severe malaria in Gabonese children. Genes Immun. 2006, 7: 393-400. 10.1038/sj.gene.6364312.CrossRefPubMed
22.
go back to reference Holmberg V, Schuster F, Dietz E, Sagarriga Visconti JC, Anemana SD, Bienzle U, Mockenhaupt FP: Mannose-binding lectin variant associated with severe malaria in young African children. Microbes Infect. 2008, 10: 342-348. 10.1016/j.micinf.2007.12.008.CrossRefPubMed Holmberg V, Schuster F, Dietz E, Sagarriga Visconti JC, Anemana SD, Bienzle U, Mockenhaupt FP: Mannose-binding lectin variant associated with severe malaria in young African children. Microbes Infect. 2008, 10: 342-348. 10.1016/j.micinf.2007.12.008.CrossRefPubMed
23.
go back to reference Thevenon AD, Leke RG, Suguitan AL, Zhou JA, Taylor DW: Genetic polymorphisms of mannose-binding lectin do not influence placental malaria but are associated with preterm deliveries. Infect Immun. 2009, 77: 1483-1491. 10.1128/IAI.01069-08.PubMedCentralCrossRefPubMed Thevenon AD, Leke RG, Suguitan AL, Zhou JA, Taylor DW: Genetic polymorphisms of mannose-binding lectin do not influence placental malaria but are associated with preterm deliveries. Infect Immun. 2009, 77: 1483-1491. 10.1128/IAI.01069-08.PubMedCentralCrossRefPubMed
24.
go back to reference Mockenhaupt FP, Bedu-Addo G, von Gaertner C, Boye R, Fricke K, Hannibal I, Karakaya F, Schaller M, Ulmen U, Acquah PA, Dietz E, Eggelte TA, Bienzle U: Detection and clinical manifestation of placental malaria in southern Ghana. Malar J. 2006, 5: 119-10.1186/1475-2875-5-119.PubMedCentralCrossRefPubMed Mockenhaupt FP, Bedu-Addo G, von Gaertner C, Boye R, Fricke K, Hannibal I, Karakaya F, Schaller M, Ulmen U, Acquah PA, Dietz E, Eggelte TA, Bienzle U: Detection and clinical manifestation of placental malaria in southern Ghana. Malar J. 2006, 5: 119-10.1186/1475-2875-5-119.PubMedCentralCrossRefPubMed
25.
go back to reference Snounou G, Viriyakosol S, Zhu XP, Jarra W, Pinheiro L, do Rosario VE, Thaithong S, Brown KN: High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol Biochem Parasitol. 1993, 61: 315-320. 10.1016/0166-6851(93)90077-B.CrossRefPubMed Snounou G, Viriyakosol S, Zhu XP, Jarra W, Pinheiro L, do Rosario VE, Thaithong S, Brown KN: High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol Biochem Parasitol. 1993, 61: 315-320. 10.1016/0166-6851(93)90077-B.CrossRefPubMed
26.
go back to reference Finnstrom O: Studies on maturity in newborn infants. IX. Further observations on the use of external characteristics in estimating gestational age. Acta Paediatr Scand. 1977, 66: 601-604. 10.1111/j.1651-2227.1977.tb07954.x.CrossRefPubMed Finnstrom O: Studies on maturity in newborn infants. IX. Further observations on the use of external characteristics in estimating gestational age. Acta Paediatr Scand. 1977, 66: 601-604. 10.1111/j.1651-2227.1977.tb07954.x.CrossRefPubMed
27.
go back to reference Silver KL, Higgins SJ, McDonald CR, Kain KC: Complement driven innate immune response to malaria: fuelling severe malarial diseases. Cell Microbiol. 2010, 12: 1036-1045. 10.1111/j.1462-5822.2010.01492.x.CrossRefPubMed Silver KL, Higgins SJ, McDonald CR, Kain KC: Complement driven innate immune response to malaria: fuelling severe malarial diseases. Cell Microbiol. 2010, 12: 1036-1045. 10.1111/j.1462-5822.2010.01492.x.CrossRefPubMed
28.
go back to reference Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC: PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007, 81: 559-575. 10.1086/519795.PubMedCentralCrossRefPubMed Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC: PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007, 81: 559-575. 10.1086/519795.PubMedCentralCrossRefPubMed
30.
go back to reference Thiel S, Kolev M, Degn S, Steffensen R, Hansen AG, Ruseva M, Jensenius JC: Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. J Immunol. 2009, 182: 2939-2947. 10.4049/jimmunol.0802053.CrossRefPubMed Thiel S, Kolev M, Degn S, Steffensen R, Hansen AG, Ruseva M, Jensenius JC: Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. J Immunol. 2009, 182: 2939-2947. 10.4049/jimmunol.0802053.CrossRefPubMed
31.
go back to reference Timmann C, Evans JA, Konig IR, Kleensang A, Ruschendorf F, Lenzen J, Sievertsen J, Becker C, Enuameh Y, Kwakye KO, Opoku E, Browne EN, Ziegler A, Nurnberg P, Horstmann RD: Genome-wide linkage analysis of malaria infection intensity and mild disease. PLoS Genet. 2007, 3: e48-10.1371/journal.pgen.0030048.PubMedCentralCrossRefPubMed Timmann C, Evans JA, Konig IR, Kleensang A, Ruschendorf F, Lenzen J, Sievertsen J, Becker C, Enuameh Y, Kwakye KO, Opoku E, Browne EN, Ziegler A, Nurnberg P, Horstmann RD: Genome-wide linkage analysis of malaria infection intensity and mild disease. PLoS Genet. 2007, 3: e48-10.1371/journal.pgen.0030048.PubMedCentralCrossRefPubMed
32.
go back to reference Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, Conway DJ, Pinder M, Sirugo G, Sisay-Joof F, Usen S, Auburn S, Bumpstead SJ, Campino S, Coffey A, Dunham A, Fry AE, Green A, Gwilliam R, Hunt SE, Inouye M, Jeffreys AE, Mendy A, Palotie A, Potter S, Ragoussis J, Rogers J, Rowlands K, Somaskantharajah E, Whittaker P, Widden C, Donnelly P, Howie B, Marchini J, Morris A, Sanjoaquin M, Achidi EA, Agbenyega T, Allen A, Amodu O, Corran P, Djimde A, Dolo A, Doumbo OK, Drakeley C, Dunstan S, Evans J, Farrar J, Fernando D, Hien TT, Horstmann RD, Ibrahim M, Karunaweera N, Kokwaro G, Koram KA, Lemnge M, Makani J, Marsh K, Michon P, Modiano D, Molyneux ME, Mueller I, Parker M, Peshu N, Plowe CV, Puijalon O, Reeder J, Reyburn H, Riley EM, Sakuntabhai A, Singhasivanon P, Sirima S, Tall A, Taylor TE, Thera M, Troye-Blomberg M, Williams TN, Wilson M, Kwiatkowski DP: Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet. 2009, 41: 657-665. 10.1038/ng.388.PubMedCentralCrossRefPubMed Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, Conway DJ, Pinder M, Sirugo G, Sisay-Joof F, Usen S, Auburn S, Bumpstead SJ, Campino S, Coffey A, Dunham A, Fry AE, Green A, Gwilliam R, Hunt SE, Inouye M, Jeffreys AE, Mendy A, Palotie A, Potter S, Ragoussis J, Rogers J, Rowlands K, Somaskantharajah E, Whittaker P, Widden C, Donnelly P, Howie B, Marchini J, Morris A, Sanjoaquin M, Achidi EA, Agbenyega T, Allen A, Amodu O, Corran P, Djimde A, Dolo A, Doumbo OK, Drakeley C, Dunstan S, Evans J, Farrar J, Fernando D, Hien TT, Horstmann RD, Ibrahim M, Karunaweera N, Kokwaro G, Koram KA, Lemnge M, Makani J, Marsh K, Michon P, Modiano D, Molyneux ME, Mueller I, Parker M, Peshu N, Plowe CV, Puijalon O, Reeder J, Reyburn H, Riley EM, Sakuntabhai A, Singhasivanon P, Sirima S, Tall A, Taylor TE, Thera M, Troye-Blomberg M, Williams TN, Wilson M, Kwiatkowski DP: Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet. 2009, 41: 657-665. 10.1038/ng.388.PubMedCentralCrossRefPubMed
33.
go back to reference Botto M, Kirschfink M, Macor P, Pickering MC, Wurzner R, Tedesco F: Complement in human diseases: lessons from complement deficiencies. Mol Immunol. 2009, 46: 2774-2783. 10.1016/j.molimm.2009.04.029.CrossRefPubMed Botto M, Kirschfink M, Macor P, Pickering MC, Wurzner R, Tedesco F: Complement in human diseases: lessons from complement deficiencies. Mol Immunol. 2009, 46: 2774-2783. 10.1016/j.molimm.2009.04.029.CrossRefPubMed
34.
go back to reference Larsen F, Madsen HO, Sim RB, Koch C, Garred P: Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein. J Biol Chem. 2004, 279: 21302-21311. 10.1074/jbc.M400520200.CrossRefPubMed Larsen F, Madsen HO, Sim RB, Koch C, Garred P: Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein. J Biol Chem. 2004, 279: 21302-21311. 10.1074/jbc.M400520200.CrossRefPubMed
35.
go back to reference Garred P, JS J, Quist L, Taaning E, Madsen HO: Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome. J Infect Dis. 2003, 188: 1394-1403. 10.1086/379044.CrossRefPubMed Garred P, JS J, Quist L, Taaning E, Madsen HO: Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome. J Infect Dis. 2003, 188: 1394-1403. 10.1086/379044.CrossRefPubMed
37.
go back to reference Jack DL, Turner MW: Anti-microbial activities of mannose-binding lectin. Biochem Soc Trans. 2003, 31: 753-757.CrossRefPubMed Jack DL, Turner MW: Anti-microbial activities of mannose-binding lectin. Biochem Soc Trans. 2003, 31: 753-757.CrossRefPubMed
38.
go back to reference Krarup A, Wallis R, Presanis JS, Gal P, Sim RB: Simultaneous activation of complement and coagulation by MBL-associated serine protease 2. PLoS One. 2007, 2: e623-10.1371/journal.pone.0000623.PubMedCentralCrossRefPubMed Krarup A, Wallis R, Presanis JS, Gal P, Sim RB: Simultaneous activation of complement and coagulation by MBL-associated serine protease 2. PLoS One. 2007, 2: e623-10.1371/journal.pone.0000623.PubMedCentralCrossRefPubMed
39.
go back to reference Conroy A, Serghides L, Finney C, Owino SO, Kumar S, Gowda DC, Liles WC, Moore JM, Kain KC: C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria. PLoS One. 2009, 4: e4953-10.1371/journal.pone.0004953.PubMedCentralCrossRefPubMed Conroy A, Serghides L, Finney C, Owino SO, Kumar S, Gowda DC, Liles WC, Moore JM, Kain KC: C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria. PLoS One. 2009, 4: e4953-10.1371/journal.pone.0004953.PubMedCentralCrossRefPubMed
40.
go back to reference Conroy AL, McDonald CR, Silver KL, Liles WC, Kain KC: Complement activation: a critical mediator of adverse fetal outcomes in placental malaria?. Trends Parasitol. 2011, 27: 294-299. 10.1016/j.pt.2011.02.005.CrossRefPubMed Conroy AL, McDonald CR, Silver KL, Liles WC, Kain KC: Complement activation: a critical mediator of adverse fetal outcomes in placental malaria?. Trends Parasitol. 2011, 27: 294-299. 10.1016/j.pt.2011.02.005.CrossRefPubMed
41.
42.
go back to reference Cockburn IA, Mackinnon MJ, O'Donnell A, Allen SJ, Moulds JM, Baisor M, Bockarie M, Reeder JC, Rowe JA: A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria. Proc Natl Acad Sci USA. 2004, 101: 272-277. 10.1073/pnas.0305306101.PubMedCentralCrossRefPubMed Cockburn IA, Mackinnon MJ, O'Donnell A, Allen SJ, Moulds JM, Baisor M, Bockarie M, Reeder JC, Rowe JA: A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria. Proc Natl Acad Sci USA. 2004, 101: 272-277. 10.1073/pnas.0305306101.PubMedCentralCrossRefPubMed
43.
go back to reference Harboe M, Garred P, Karlstrom E, Lindstad JK, Stahl GL, Mollnes TE: The down-stream effects of mannan-induced lectin complement pathway activation depend quantitatively on alternative pathway amplification. Mol Immunol. 2009, 47: 373-380. 10.1016/j.molimm.2009.09.005.CrossRefPubMed Harboe M, Garred P, Karlstrom E, Lindstad JK, Stahl GL, Mollnes TE: The down-stream effects of mannan-induced lectin complement pathway activation depend quantitatively on alternative pathway amplification. Mol Immunol. 2009, 47: 373-380. 10.1016/j.molimm.2009.09.005.CrossRefPubMed
44.
go back to reference Kocsis A, Kekesi KA, Szasz R, Vegh BM, Balczer J, Dobo J, Zavodszky P, Gal P, Pal G: Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation. J Immunol. 2010, 185: 4169-4178. 10.4049/jimmunol.1001819.CrossRefPubMed Kocsis A, Kekesi KA, Szasz R, Vegh BM, Balczer J, Dobo J, Zavodszky P, Gal P, Pal G: Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation. J Immunol. 2010, 185: 4169-4178. 10.4049/jimmunol.1001819.CrossRefPubMed
Metadata
Title
Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria
Authors
Ville Holmberg
Päivi Onkamo
Elisa Lahtela
Päivi Lahermo
George Bedu-Addo
Frank P Mockenhaupt
Seppo Meri
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2012
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-11-61

Other articles of this Issue 1/2012

Malaria Journal 1/2012 Go to the issue