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Open Access 01-12-2012 | Commentary

Malaria research challenges in low prevalence settings

Authors: Gillian Stresman, Tamaki Kobayashi, Aniset Kamanga, Philip E Thuma, Sungano Mharakurwa, William J Moss, Clive Shiff

Published in: Malaria Journal | Issue 1/2012

Abstract

The prevalence of malaria has reduced significantly in some areas over the past decade. These reductions have made local elimination possible and the research agenda has shifted to this new priority. However, there are critical issues that arise when studying malaria in low transmission settings, particularly identifying asymptomatic infections, accurate detection of individuals with microparasitaemic infections, and achieving a sufficient sample size to have an adequately powered study. These challenges could adversely impact the study of malaria elimination if they remain unanswered.

Hay SI, Guerra CA, Tatem AJ, Noor AM, Snow RW: The global distribution and population at risk of malaria: past, present, and future. Lancet Infect Dis. 2004, 4: 327-336. 10.1016/S1473-3099(04)01043-6.PubMedCentralCrossRefPubMed

Najera JA, Gonzales-Silva M, Alonso PL: Some lessons for the future from the Global Malaria Eradication Programme (1955–1969). PLoS Med. 2011, 8: e1000412-10.1371/journal.pmed.1000412.PubMedCentralCrossRefPubMed

Gething PW, Patil AP, Smith DL, Guerra CA, Elyazar IR, Johnston GL, Tatem AJ, Hay SI: A new world map: Plasmodium falciparum endemicity in 2010. Malar J. 2011, 10: 378-10.1186/1475-2875-10-378.PubMedCentralCrossRefPubMed

Shiff C: Integrated approach to malaria control. Clin Microbiol Rev. 2002, 15: 278-293. 10.1128/CMR.15.2.278-293.2002.PubMedCentralCrossRefPubMed

Lindsay SW, Snow RW, Broomfield GL, Janneh MS, Wirtz RA, Greenwood BM: Impact of permethrin-treated bedents on malaria transmission by the Anopheles gambiae complex in The Gambia. Med Vet Entomol. 1989, 3: 263-271. 10.1111/j.1365-2915.1989.tb00226.x.CrossRefPubMed

Mharakurwa S, Manyame B, Shiff CJ: Trial of the ParaSight-F test for malaria diagnosis in the primary health care system. Zimbabwe. Trop Med Int Health. 1997, 2: 544-550.CrossRefPubMed

Price RN, Nosten F, Luxemburger C, ter Kulle FO, Paiphun L, Chongsuphajaisiddhi T, White NJ: Effects of artemisinin derivatives on malaria transmissibility. Lancet. 1996, 347: 1654-1658. 10.1016/S0140-6736(96)91488-9.CrossRefPubMed

Kitua A, Ogundahunsi O, Lines J, Mgone C: Conquering malaria: enhancing the impact of effective interventions towards elimination in the diverse and changing epidemiology. J Glob Infect Dis. 2011, 3: 161-165. 10.4103/0974-777X.81694.PubMedCentralCrossRefPubMed

malERA Consultative Group on Diagnoses and Diagnostics: A research agenda for malaria eradication: diagnoses and diagnostics. PLoS Med. 2011, 8: e1000396-CrossRef

10.

Manjurano A, Okell L, Lukindo T, Reyburn H, Olomi R, Roper C, Clark TG, Goseph S, Riley EM, Drakeley C: Association of sub-microscopic malaria parasite carriage with transmission intensity in north-eastern Tanzania. Malar J. 2011, 10: 370-10.1186/1475-2875-10-370.PubMedCentralCrossRefPubMed

11.

Bousema T, Griffin JT, Sauervwein RW, Smith DL, Churcher TS, Takken W, Ghani A, Drakeley C, Gosling R: Hitting hotspots: spatial targeting of malaria for control and elimination. PLoS Med. 2012, 9: e1001165-10.1371/journal.pmed.1001165.PubMedCentralCrossRefPubMed

12.

Harris I, Sharrock WW, Bain LM, Gray KA, Bobogare A, Boaz L, Lilley K, Krause D, Vallely A, Johnson ML, Gatton ML, Shanks GD, Cheng Q: A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting. Malar J. 2010, 9: 254-10.1186/1475-2875-9-254.PubMedCentralCrossRefPubMed

13.

Baliraine FN, Afrane YA, Amenya DA, Bonizzoni M, Menge DM, Zhou G, Zhong D, Vardo-Zalik AM, Githeko A, Yan G: High prevalence of asymptomatic Plasmodium falciparum infections in a highland area of western Kenya: A cohort study. J Infect Dis. 2009, 200: 66-74. 10.1086/599317.PubMedCentralCrossRefPubMed

14.

Manjurano A, Okell L, Lukindo T, Reyburn H, Olomi R, Roper C, Clark TG, Joseph S, Riley EM, Drakeley C: Association of sub-microscopic malaria parasite carriage with transmission intensity in north-eastern Tanzania. Malar J. 2011, 10: 370-10.1186/1475-2875-10-370.PubMedCentralCrossRefPubMed

15.

Karl S, Gurarie D, Zimmerman PA, King CH, St Pierre TG, Davis TM: A sub-microscopic gametocyte reservoir can sustain malaria transmission. PLoS One. 2011, 6: e20805-10.1371/journal.pone.0020805.PubMedCentralCrossRefPubMed

16.

Sutcliffe CG, Kobayashi T, Hamapumbu H, Shields T, Kamanga A, Mharakurwa S, Thuma PE, Glass G, Moss WJ: Changing individual-level risk factors for malaria with declining transmission in southern Zambia: a cross-sectional study. Malar J. 2011, 10: 324-10.1186/1475-2875-10-324.PubMedCentralCrossRefPubMed

17.

Stresman GH, Kamanga A, Moono P, Hamapumbu H, Mharakurwa S, Kobayashi T, Moss WJ, Shiff C: A method of active case detection to target reservoirs of asymptomatic malaria and gametocyte carriers in a rural area in Southern Province. Zambia. Malar J. 2010, 9: 265-PubMed

18.

Sutcliffe CG, Kobayashi T, Hamapumbu H, Shields T, Mharakurwa S, Thuma PE, Louis TA, Glass G, Moss WJ: Reduced risk of malaria parasitemia following household screening and treatment: A cross-sectional and longitudinal cohort study. PLoS One. 2012, 7: e31396-10.1371/journal.pone.0031396.PubMedCentralCrossRefPubMed

19.

Bousema T, Drakeley C: Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination. Clin Microbiol Rev. 2011, 24: 377-410. 10.1128/CMR.00051-10.PubMedCentralCrossRefPubMed

20.

Moss WJ, Hamapumbu H, Kobayashi T, Shields T, Kamanga A, Clennon J, Mharakurwa S, Thuma PE, Glass G: Use of remote sensing to identify spatial risk factors for malaria in a region of declining transmission. Malar J. 2011, 10: 163-10.1186/1475-2875-10-163.PubMedCentralCrossRefPubMed

21.

Coleman RE, Kumpitak C, Ponlawat A, Maneechai N, Phunkitchar CV, Rachapaeq N, Zollner G, Sattabongkot J: Infectivity of asymptomatic Plasmodium-infected human populations to Anopheles dirus mosquitoes in western Thailand. J Med Entomol. 2004, 41: 201-208. 10.1603/0022-2585-41.2.201.CrossRefPubMed

22.

Poschl B, Waneesorn J, Thekisoe O, Chutipongvivate S, Panagiotis K: Comparative diagnosis of malaria infections by microscopy, nested PCR, and LAMP in Northern Thailand. AmJTrop Med Hyg. 2010, 83: 56-60.CrossRef

23.

McMorrow ML, Aidoo M, Kachur SP: Malaria rapid diagnostic tests in elimination settings –can they find the last parasite?. Clin Microbiol Infect. 2011, 17: 1624-1631. 10.1111/j.1469-0691.2011.03639.x.CrossRefPubMed

24.

Schachterle SE, Ntove G, Levens JP, Clemens EG, Shi L, Raj A, Munoz B, Reller ME, West S, Dumler JS, Sullivan D: Prevalence and density-related concordance of three diagnostic tests for malaria in a region of Tanzania with hypoendemic malaria. J Clin Microbiol. 2011, 49: 3885-3891. 10.1128/JCM.01157-11.PubMedCentralCrossRefPubMed

25.

Mahajan B, Zheng H, Pham PT, Sedegah MY, Majam VF, Akolkar N, Rios M, Ankrah I, Madjitey P, Amoah G, Addison E, Quakyi IA, Kumar S: Polymerase chain reaction-based tests for pan-species and species-specific detection of human Plasmodium parasites. Transfusion. 2012, 10.1111/j.1537-2995.2011.03541.x.

26.

Shekalaghe SA, Drakeley C, van den Bosch S, ter Braak R, van den Bijllaardt W, Mwanziva C, Semvua S, Masokoto A, Mosha F, Teelen K, Hermsen R, Okell L, Gosling R, Sauerwein R, Bousema T: A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania. Malar J. 2011, 10: 247-10.1186/1475-2875-10-247.PubMedCentralCrossRefPubMed

27.

Greenwood BM: The micro epidemiology of malaria and its importance to malaria control. Trans R Soc Trop Med Hyg. 1989, 83 (Suppl): 25-29.CrossRefPubMed

28.

Smith DL, Dushoff J, Snow RW, Hay SI: The entomological inoculation rate and Plasmodium falciparum infection in African children. Nature. 2005, 438: 492-495. 10.1038/nature04024.PubMedCentralCrossRefPubMed

29.

WHO: Global malaria control and elimination: report of a technical review. 2008, World Health Organization

Title: Malaria research challenges in low prevalence settings
Authors: Gillian Stresman
Tamaki Kobayashi
Aniset Kamanga
Philip E Thuma
Sungano Mharakurwa
William J Moss
Clive Shiff
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Malaria Journal / Issue 1/2012
Electronic ISSN: 1475-2875
DOI: https://doi.org/10.1186/1475-2875-11-353

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