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Malaria Journal
Published in: Malaria Journal 1/2011

Open Access 01-12-2011 | Research

Vivax malaria in Mauritania includes infection of a Duffy-negative individual

Authors: Nathalie Wurtz, Khadijetou Mint Lekweiry, Hervé Bogreau, Bruno Pradines, Christophe Rogier, Ali Ould Mohamed Salem Boukhary, Jamal Eddine Hafid, Mohamed Salem Ould Ahmedou Salem, Jean-François Trape, Leonardo K Basco, Sébastien Briolant

Published in: Malaria Journal | Issue 1/2011

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Abstract

Background

Duffy blood group polymorphisms are important in areas where Plasmodium vivax is present because this surface antigen is thought to act as a key receptor for this parasite. In the present study, Duffy blood group genotyping was performed in febrile uninfected and P. vivax-infected patients living in the city of Nouakchott, Mauritania.

Methods

Plasmodium vivax was identified by real-time PCR. The Duffy blood group genotypes were determined by standard PCR followed by sequencing of the promoter region and exon 2 of the Duffy gene in 277 febrile individuals. Fisher's exact test was performed in order to assess the significance of variables.

Results

In the Moorish population, a high frequency of the FYB ES /FYB ES genotype was observed in uninfected individuals (27.8%), whereas no P. vivax-infected patient had this genotype. This was followed by a high level of FYA/FYB, FYB/FYB, FYB/FYB ES and FYA/FYB ES genotype frequencies, both in the P. vivax-infected and uninfected patients. In other ethnic groups (Poular, Soninke, Wolof), only the FYB ES /FYB ES genotype was found in uninfected patients, whereas the FYA/FYB ES genotype was observed in two P. vivax-infected patients. In addition, one patient belonging to the Wolof ethnic group presented the FYB ES /FYB ES genotype and was infected by P. vivax.

Conclusions

This study presents the Duffy blood group polymorphisms in Nouakchott City and demonstrates that in Mauritania, P. vivax is able to infect Duffy-negative patients. Further studies are necessary to identify the process that enables this Duffy-independent P. vivax invasion of human red blood cells.
Appendix
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Metadata
Title
Vivax malaria in Mauritania includes infection of a Duffy-negative individual
Authors
Nathalie Wurtz
Khadijetou Mint Lekweiry
Hervé Bogreau
Bruno Pradines
Christophe Rogier
Ali Ould Mohamed Salem Boukhary
Jamal Eddine Hafid
Mohamed Salem Ould Ahmedou Salem
Jean-François Trape
Leonardo K Basco
Sébastien Briolant
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2011
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-10-336

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