Skip to main content
Top
Published in: Malaria Journal 1/2011

Open Access 01-12-2011 | Research

Pharmaceutical services for endemic situations in the Brazilian Amazon: organization of services and prescribing practices for Plasmodium vivax and Plasmodium falciparum non-complicated malaria in high-risk municipalities

Authors: Martha C Suárez-Mutis, Paula P de Souza, Letícia F Freitas, Elaine S Miranda, Mônica R Campos, Claudia GS Osorio-de-Castro

Published in: Malaria Journal | Issue 1/2011

Login to get access

Abstract

Background

In spite of the fact that pharmaceutical services are an essential component of all malaria programmes, quality of these services has been little explored in the literature. This study presents the first results of the application of an evaluation model of pharmaceutical services in high-risk municipalities of the Amazon region, focusing on indicators regarding organization of services and prescribing according to national guidelines.

Methods

A theoretical framework of pharmaceutical services for non-complicated malaria was built based on the Rapid Evaluation Method (WHO). The framework included organization of services and prescribing, among other activities. The study was carried out in 15 primary health facilities in six high-risk municipalities of the Brazilian Amazon. Malaria individuals ≥ 15 years old were approached and data was collected using specific instruments. Data was checked by independent reviewers and fed to a data bank through double-entry. Descriptive variables were analyzed.

Results

A copy of the official treatment guideline was found in 80% of the facilities; 67% presented an environment for receiving and prescribing patients. Re-supply of stocks followed a different timeline; no facilities adhered to forecasting methods for stock management. No shortages or expired anti-malarials were observed, but overstock was a common finding. On 86.7% of facilities, the average of good storage practices was 48%. Time between diagnosis and treatment was zero days. Of 601 patients interviewed, 453 were diagnosed for Plasmodium vivax; of these, 99.3% received indications for the first-line scheme. Different therapeutic schemes were given to Plasmodium falciparum patients. Twenty-eight (4.6%) out of 601 were prescribed regimens not listed in the national guideline. Only 5.7% individuals received a prescription or a written instruction of any kind.

Conclusions

The results show that while diagnostic procedure is well established and functioning in the Brazilian malaria programme, prescribing is still an activity that is actually not performed. The absence of physicians and poor integration between malaria services and primary health services make for the lack of a prescription or written instruction for malaria patients throughout the Brazilian Amazon. This fact may lead to a great number of problems in rational use and in adherence to medication.
Appendix
Available only for authorised users
Literature
1.
go back to reference Oliveira-Ferreira J, Lacerda MVG, Brasil P, Ladislau JLB, Tauil PL, Daniel-Ribeiro CT: Malaria in Brazil: an overview. Malar J. 2010, 9: 115-10.1186/1475-2875-9-115.PubMedCentralCrossRefPubMed Oliveira-Ferreira J, Lacerda MVG, Brasil P, Ladislau JLB, Tauil PL, Daniel-Ribeiro CT: Malaria in Brazil: an overview. Malar J. 2010, 9: 115-10.1186/1475-2875-9-115.PubMedCentralCrossRefPubMed
2.
go back to reference Loiola CCP, da Silva CJM, Tauil PL: Controle da malária no Brasil: 1965 a 2001. Pan Am J Public Health. 2002, 11: 235-244. 10.1590/S1020-49892002000400005.CrossRef Loiola CCP, da Silva CJM, Tauil PL: Controle da malária no Brasil: 1965 a 2001. Pan Am J Public Health. 2002, 11: 235-244. 10.1590/S1020-49892002000400005.CrossRef
4.
go back to reference Ferreira MU, da Silva-Nunes M: Evidence-based public health and prospects for malaria control in Brazil. J Infect Develop Countries. 2010, 4: 533-45. Ferreira MU, da Silva-Nunes M: Evidence-based public health and prospects for malaria control in Brazil. J Infect Develop Countries. 2010, 4: 533-45.
6.
go back to reference Santana-Filho FS, Arcanjo ARL, Costa MR, FE M-E, Vieira JL, Barbosa MGV, Alecrim WD, Alecrim MG: Chloroquine-resistant Plasmodium vivax, Brazilian Amazon. Emerg Infect Dis. 2007, 13: 1125-1126.PubMedCentralCrossRefPubMed Santana-Filho FS, Arcanjo ARL, Costa MR, FE M-E, Vieira JL, Barbosa MGV, Alecrim WD, Alecrim MG: Chloroquine-resistant Plasmodium vivax, Brazilian Amazon. Emerg Infect Dis. 2007, 13: 1125-1126.PubMedCentralCrossRefPubMed
8.
go back to reference MS (Ministério da Saúde), SVS (Secretaria de Vigilância em Saúde), DVE (Departamento de Vigilância Epidemiológica): Guia prático de tratamento da malária no Brasil. 2010, Brasília: Ministério da Saúde MS (Ministério da Saúde), SVS (Secretaria de Vigilância em Saúde), DVE (Departamento de Vigilância Epidemiológica): Guia prático de tratamento da malária no Brasil. 2010, Brasília: Ministério da Saúde
9.
go back to reference Ministério da Saúde/Secretaria de Vigilância em Saúde: Programa Nacional de Prevenção e Controle da Malária - PNCM. 2003, Brasília: FUNASA Ministério da Saúde/Secretaria de Vigilância em Saúde: Programa Nacional de Prevenção e Controle da Malária - PNCM. 2003, Brasília: FUNASA
10.
go back to reference Freitas LF, Chaves GC, Wannmacher L, Osorio-de-Castro CGS: Malária não-complicada por P. vivax e P. falciparum no Brasil: evidências sobre fármacos isolados e associações medicamentosas empregados em esquemas terapêuticos recomendados pelo protocolo terapêutico oficia. Cad Saúde Pública. 2007, 23: 2285-2294.PubMed Freitas LF, Chaves GC, Wannmacher L, Osorio-de-Castro CGS: Malária não-complicada por P. vivax e P. falciparum no Brasil: evidências sobre fármacos isolados e associações medicamentosas empregados em esquemas terapêuticos recomendados pelo protocolo terapêutico oficia. Cad Saúde Pública. 2007, 23: 2285-2294.PubMed
11.
go back to reference Araujo ALA, Pereira LRL, Ueta JM, Freitas O: Perfil da assistência farmacêutica na atenção primária do Sistema Único de Saúde. Cien Saude Colet. 2008, 13 (supl): 611-617.CrossRef Araujo ALA, Pereira LRL, Ueta JM, Freitas O: Perfil da assistência farmacêutica na atenção primária do Sistema Único de Saúde. Cien Saude Colet. 2008, 13 (supl): 611-617.CrossRef
12.
go back to reference Osorio-de-Castro CGS, Chaves GC, Ruiz AM, Miranda ES, Campos MR, Suárez-Mutis MC, Freitas LF: A proposal for an evaluation model of pharmaceutical services for malaria. Cad Saúde Pública. 2009, 25: 2075-2082.CrossRefPubMed Osorio-de-Castro CGS, Chaves GC, Ruiz AM, Miranda ES, Campos MR, Suárez-Mutis MC, Freitas LF: A proposal for an evaluation model of pharmaceutical services for malaria. Cad Saúde Pública. 2009, 25: 2075-2082.CrossRefPubMed
13.
go back to reference World Health Organization, Management Science for Health: How to investigate drug use in health facilities: Selected drug use indicators. 1993, Geneva: WHO World Health Organization, Management Science for Health: How to investigate drug use in health facilities: Selected drug use indicators. 1993, Geneva: WHO
14.
go back to reference MSH/RPMP (Management Sciences for Health/Rational Pharmaceutical Management Project): Rapid pharmaceutical Management Assessment: an indicator based approach. 1995, MSH MSH/RPMP (Management Sciences for Health/Rational Pharmaceutical Management Project): Rapid pharmaceutical Management Assessment: an indicator based approach. 1995, MSH
15.
go back to reference Oliveira MA, Esher AFSC, Santos EM, Cosendey MA, Luiza VL, Bermudez JAZ: Avaliação da assistência farmacêutica às pessoas vivendo com HIV/AIDS no município do Rio de Janeiro. Cad Saúde Pública. 2002, 18: 1429-1439.CrossRefPubMed Oliveira MA, Esher AFSC, Santos EM, Cosendey MA, Luiza VL, Bermudez JAZ: Avaliação da assistência farmacêutica às pessoas vivendo com HIV/AIDS no município do Rio de Janeiro. Cad Saúde Pública. 2002, 18: 1429-1439.CrossRefPubMed
16.
go back to reference Clark M: Drug management for malaria manual. 2000, Arlington: MSH (Management Science for Health) Clark M: Drug management for malaria manual. 2000, Arlington: MSH (Management Science for Health)
17.
go back to reference Fundação Nacional de Saúde/Ministério da Saúde: Manual de terapêutica da malária. 2001, Brasília: Fundação Nacional de Saúde/Ministério da Saúde; Fundação Nacional de Saúde/Ministério da Saúde: Manual de terapêutica da malária. 2001, Brasília: Fundação Nacional de Saúde/Ministério da Saúde;
18.
go back to reference Osorio-de-Castro CGS, Miranda ES, Esher AFSC, Campos MR, Brasil JC, Ferreira ACS, Emmerick ICM: Conhecimentos, práticas e percepções de profissionais de saúde sobre o tratamento de malária não complicada em municípios de alto risco da Amazônia Legal. Cien Saude Colet. 2011, 16: 1445-1456.CrossRefPubMed Osorio-de-Castro CGS, Miranda ES, Esher AFSC, Campos MR, Brasil JC, Ferreira ACS, Emmerick ICM: Conhecimentos, práticas e percepções de profissionais de saúde sobre o tratamento de malária não complicada em municípios de alto risco da Amazônia Legal. Cien Saude Colet. 2011, 16: 1445-1456.CrossRefPubMed
19.
go back to reference Mubyazi GM, Gonzalez-Block MA: Research influence on antimalarial drug policy change in Tanzania: case study of replacing chloroquine with sulfadoxine-pyrimethamine as the first-line drug. Malar J. 2005, 4: 51-10.1186/1475-2875-4-51.PubMedCentralCrossRefPubMed Mubyazi GM, Gonzalez-Block MA: Research influence on antimalarial drug policy change in Tanzania: case study of replacing chloroquine with sulfadoxine-pyrimethamine as the first-line drug. Malar J. 2005, 4: 51-10.1186/1475-2875-4-51.PubMedCentralCrossRefPubMed
20.
go back to reference Rahman MM, Dondorp AM, Day NP, Lindegardh N, Imwong M, Faiz MA, Bangali AM, Kamal AT, Karim J, Kaewkungwal J, Singhasivanon P: Adherence and efficacy of supervised versus non-supervised treatment with artemether/lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh: a randomised controlled trial. Trans R Soc Trop Med Hyg. 2008, 102: 861-867. 10.1016/j.trstmh.2008.05.022.CrossRefPubMed Rahman MM, Dondorp AM, Day NP, Lindegardh N, Imwong M, Faiz MA, Bangali AM, Kamal AT, Karim J, Kaewkungwal J, Singhasivanon P: Adherence and efficacy of supervised versus non-supervised treatment with artemether/lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh: a randomised controlled trial. Trans R Soc Trop Med Hyg. 2008, 102: 861-867. 10.1016/j.trstmh.2008.05.022.CrossRefPubMed
21.
go back to reference Nogueira FHA: Avaliação pontual da qualidade de antimaláricos no Sistema Único de Saúde - SUS. 2007, Belo Horizonte: Universidade Federal de Minas Gerais; Faculdade de Farmácia Nogueira FHA: Avaliação pontual da qualidade de antimaláricos no Sistema Único de Saúde - SUS. 2007, Belo Horizonte: Universidade Federal de Minas Gerais; Faculdade de Farmácia
22.
go back to reference Noor AM, Rage IA, Moonen B, Snow R: Health service providers in Somalia: their readiness to provide malaria case-management. Malar J. 2009, 8: 100-10.1186/1475-2875-8-100.PubMedCentralCrossRefPubMed Noor AM, Rage IA, Moonen B, Snow R: Health service providers in Somalia: their readiness to provide malaria case-management. Malar J. 2009, 8: 100-10.1186/1475-2875-8-100.PubMedCentralCrossRefPubMed
23.
go back to reference Onwujekwe O, Uzochukwu B, Eze S, Obikeze E, Okoli C, Ochonma O: Improving equity in malaria treatment: Relationship of socio-economic status with health seeking as well as with perceptions of ease of using the services of different providers for the treatment of malaria in Nigeria. Malar J. 2008, 7: 5-10.1186/1475-2875-7-5.PubMedCentralCrossRefPubMed Onwujekwe O, Uzochukwu B, Eze S, Obikeze E, Okoli C, Ochonma O: Improving equity in malaria treatment: Relationship of socio-economic status with health seeking as well as with perceptions of ease of using the services of different providers for the treatment of malaria in Nigeria. Malar J. 2008, 7: 5-10.1186/1475-2875-7-5.PubMedCentralCrossRefPubMed
24.
go back to reference World Health Organization: World Malaria Report. 2009, Geneva: WHO World Health Organization: World Malaria Report. 2009, Geneva: WHO
25.
go back to reference Mannan AA, Malik EM, Ali KM: Antimalarial prescribing and dispensing practices in health centres of Khartoum State, 2003-04. East Mediterr Health J. 2009, 15: 122-128.PubMed Mannan AA, Malik EM, Ali KM: Antimalarial prescribing and dispensing practices in health centres of Khartoum State, 2003-04. East Mediterr Health J. 2009, 15: 122-128.PubMed
26.
go back to reference Okebe JU, Walther B, Bojang K, Drammeh S, Schellenberg D, Conway DJ, Walther M: Prescribing practice for malaria following introduction of artemether-lumefantrine in an urban area with declining endemicity in West Africa. Malar J. 2010, 9: 180-10.1186/1475-2875-9-180.PubMedCentralCrossRefPubMed Okebe JU, Walther B, Bojang K, Drammeh S, Schellenberg D, Conway DJ, Walther M: Prescribing practice for malaria following introduction of artemether-lumefantrine in an urban area with declining endemicity in West Africa. Malar J. 2010, 9: 180-10.1186/1475-2875-9-180.PubMedCentralCrossRefPubMed
27.
go back to reference Nsimba SE, Massele AY, Eriksen J, Gustafsson LL, Tomson G, Warsame M: Case management of malaria in under-fives at primary health care facilities in a Tanzanian district. Trop Med Int Health. 2002, 7: 201-209. 10.1046/j.1365-3156.2002.00847.x.CrossRefPubMed Nsimba SE, Massele AY, Eriksen J, Gustafsson LL, Tomson G, Warsame M: Case management of malaria in under-fives at primary health care facilities in a Tanzanian district. Trop Med Int Health. 2002, 7: 201-209. 10.1046/j.1365-3156.2002.00847.x.CrossRefPubMed
28.
go back to reference Andrade BB, Reis-Filho A, Barros AM, Souza-Neto SM, Nogueira LL, Fukutani KF, Camargo LMA, Barral A, Duarte A, Barral-Neto M: Towards a precise test for malaria diagnosis in the Brazilian Amazon: comparison among field microscopy, a rapid diagnostic test, nested PCR, and a computational expert system based on artificial neural networks. Malar J. 2010, 9: 117-10.1186/1475-2875-9-117.PubMedCentralCrossRefPubMed Andrade BB, Reis-Filho A, Barros AM, Souza-Neto SM, Nogueira LL, Fukutani KF, Camargo LMA, Barral A, Duarte A, Barral-Neto M: Towards a precise test for malaria diagnosis in the Brazilian Amazon: comparison among field microscopy, a rapid diagnostic test, nested PCR, and a computational expert system based on artificial neural networks. Malar J. 2010, 9: 117-10.1186/1475-2875-9-117.PubMedCentralCrossRefPubMed
29.
go back to reference Brasil: Portaria N° 2.143, de 09 de outubro de 2008. Cria o incentivo financeiro referente à inclusão do microscopista na atenção básica para realizar, prioritariamente, ações de controle da malária junto às Equipes de Agentes Comunitários de Saúde - EACS e/ou às Equipes de Saúde da Família E S F. Edited by: Ministério da Saúde/Gabinete do Ministro. 2008, Brasília; Brasil: Portaria N° 2.143, de 09 de outubro de 2008. Cria o incentivo financeiro referente à inclusão do microscopista na atenção básica para realizar, prioritariamente, ações de controle da malária junto às Equipes de Agentes Comunitários de Saúde - EACS e/ou às Equipes de Saúde da Família E S F. Edited by: Ministério da Saúde/Gabinete do Ministro. 2008, Brasília;
30.
go back to reference Bell DJ, Wotton D, Mukaka M, Montgomery J, Kayange N, Chimpeni P, Hughes DA, Molyneux ME, Ward SA, Winstanley PA, Lalloo DG: Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi. Malar J. 2009, 8: 204-10.1186/1475-2875-8-204.PubMedCentralCrossRefPubMed Bell DJ, Wotton D, Mukaka M, Montgomery J, Kayange N, Chimpeni P, Hughes DA, Molyneux ME, Ward SA, Winstanley PA, Lalloo DG: Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi. Malar J. 2009, 8: 204-10.1186/1475-2875-8-204.PubMedCentralCrossRefPubMed
33.
go back to reference Khantikul N, Butraporn P, Kim HS, Leemingsawat S, Tempongko MA, Suwonkerd W: Adherence to antimalarial drug therapy among vivax malaria patients in northern Thailand. J Health Popul Nutr. 2009, 27: 4-13.PubMedCentralCrossRefPubMed Khantikul N, Butraporn P, Kim HS, Leemingsawat S, Tempongko MA, Suwonkerd W: Adherence to antimalarial drug therapy among vivax malaria patients in northern Thailand. J Health Popul Nutr. 2009, 27: 4-13.PubMedCentralCrossRefPubMed
34.
go back to reference Osterberg LMD, Blaschke TMD: Drug therapy: Adherence to Medication. N Engl J Med. 2005, 353: 487-497. 10.1056/NEJMra050100.CrossRefPubMed Osterberg LMD, Blaschke TMD: Drug therapy: Adherence to Medication. N Engl J Med. 2005, 353: 487-497. 10.1056/NEJMra050100.CrossRefPubMed
35.
go back to reference Jin J, Sklar GE, Oh VMS, Li SC: Factors affecting therapeutic compliance: A rteview from the patien's perspective. Ther Clin Risk Manag. 2008, 4: 1- Jin J, Sklar GE, Oh VMS, Li SC: Factors affecting therapeutic compliance: A rteview from the patien's perspective. Ther Clin Risk Manag. 2008, 4: 1-
36.
go back to reference Brasil: Portaria n.° 44/GM, de 03 de janeiro de 2002. Estabelece as atribuições do agente comunitário de saúde na prevenção e controle da malária e da dengue. 2002, Brasília; Brasil: Portaria n.° 44/GM, de 03 de janeiro de 2002. Estabelece as atribuições do agente comunitário de saúde na prevenção e controle da malária e da dengue. 2002, Brasília;
38.
go back to reference Unger JP, d'Alessandro U, De Paepe P, Green A: Can malaria be controlled where basic health services are not used?. Trop Med Int Health. 2006, 2: 314-322.CrossRef Unger JP, d'Alessandro U, De Paepe P, Green A: Can malaria be controlled where basic health services are not used?. Trop Med Int Health. 2006, 2: 314-322.CrossRef
40.
go back to reference Roll Back Malaria: Global Malaria Action Plan: For a malaria-free world. 2008, Geneva: Roll Back Malaria Roll Back Malaria: Global Malaria Action Plan: For a malaria-free world. 2008, Geneva: Roll Back Malaria
41.
go back to reference Greenwood BM: Control to elimination: implications for malaria research. Trends Parasitol. 2008, 24: 449-454. 10.1016/j.pt.2008.07.002.CrossRefPubMed Greenwood BM: Control to elimination: implications for malaria research. Trends Parasitol. 2008, 24: 449-454. 10.1016/j.pt.2008.07.002.CrossRefPubMed
Metadata
Title
Pharmaceutical services for endemic situations in the Brazilian Amazon: organization of services and prescribing practices for Plasmodium vivax and Plasmodium falciparum non-complicated malaria in high-risk municipalities
Authors
Martha C Suárez-Mutis
Paula P de Souza
Letícia F Freitas
Elaine S Miranda
Mônica R Campos
Claudia GS Osorio-de-Castro
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2011
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-10-335

Other articles of this Issue 1/2011

Malaria Journal 1/2011 Go to the issue