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Open Access 01-12-2012 | Review

Vascular memory: can we broaden the concept of the metabolic memory?

Author: György Jermendy

Published in: Cardiovascular Diabetology | Issue 1/2012

Abstract

Based on the results of recent randomized, controlled clinical trials and analyses of their follow-up periods the concept of metabolic memory cannot be restricted to antihyperglycaemic treatment only, rather it can be extended to lipid-lowering and antihypertensive treatment and even life-style modification. This broadened concept can be designated as vascular memory. According to this new concept, not only immediate and short-term but long-term effects of the metabolic and cardiovascular risk milieu are of great importance. Consequently, early and intensive lifestyle interventions, treatment of hyperglycaemia, lipid abnormalities and hypertension can result in beneficial effects on cardiovascular outcomes even in the long run. On the contrary, failing in target-oriented treatment from early detection of abnormalities can be associated with life-threatening cardiovascular events subsequently. Additional experimental studies are needed to characterize the exact pathomechanism of vascular memory and further clinical trials are also essential to explore its real clinical significance.

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Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, Raskin P, Zimmet B, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group: Intensive treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005, 353: 2643-2653.CrossRefPubMed

Ceriello A, Ihnat MA, Thorpe JE: The “metabolic memory”: is more than just tight glucose control necessary to prevent diabetic complications?. J Clin Endocrinol Metab. 2009, 94: 410-415. 10.1210/jc.2008-1824.CrossRefPubMed

Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA: 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008, 359: 1577-1589. 10.1056/NEJMoa0806470.CrossRefPubMed

The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993, 329: 977-986.CrossRef

Epidemiology of Diabetes Interventions and Complications (EDIC): Design, implementation, and preliminary results of a long-term follow-up of the Diabetes Control and Complications Trial cohort. Diabetes Care. 1999, 22: 99-111.CrossRef

The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group: Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. N Engl J Med. 2000, 342: 381-389.PubMedCentralCrossRef

White NH, Sun W, Cleary PA, Danis RP, Davis MD, Hainsworth DP, Hubbard LD, Lachin JM, Nathan DM: Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial. Arch Ophthalmol. 2008, 126: 1707-1715.CrossRefPubMed

Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group: Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus. JAMA. 2002, 287: 2563-2569. 10.1001/jama.287.19.2563.CrossRef

de Boer IH, Rue TC, Cleary PA, Lachin JM, Molitch ME, Steffes MW, Sun W, Zinman B, Brunzell JD, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group: Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: an analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort. Arch Intern Med. 2011, 171: 412-420. 10.1001/archinternmed.2011.16.PubMedCentralCrossRefPubMed

10.

de Boer IH, Sun W, Cleary PA, Lachin JM, Molitch ME, Steffes MW, Zinman B, The DCCT/EDIC Research Group: Intensive diabetes therapy and glomerular filtration rate in type 1 diabetes. N Engl J Med. 2011, 365: 2366-2376.CrossRefPubMed

11.

Martin CL, Albers J, Herman WH, Cleary P, Waberski B, Greene DA, Stevens MJ, Feldman EL, DCCT/EDIC Research Group: Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion. Diabetes Care. 2006, 29: 340-344. 10.2337/diacare.29.02.06.dc05-1549.PubMedCentralCrossRefPubMed

12.

Albers JW, Herman WH, Pop-Busui R, Feldman EL, Martin CL, Cleary PA, Waberski BH, Lachin JM, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group: Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the Epidemiology of Diabetes Interventions and Complications (EDIC) Study. Diabetes Care. 2010, 33: 1090-1096. 10.2337/dc09-1941.PubMedCentralCrossRefPubMed

13.

Pop-Busui R, Low PA, Waberski BH, Martin CL, Albers JW, Feldman EL, Sommer C, Cleary PA, Lachin JM, Herman WH, DCCT/EDIC Research Group: Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 diabetes mellitus: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC). Circulation. 2009, 119: 2886-2893. 10.1161/CIRCULATIONAHA.108.837369.PubMedCentralCrossRefPubMed

14.

Nathan DM, Lachin J, Cleary P, Orchard T, Brillon DJ, Backlund JY, O'Leary DH, Genuth S, Diabetes Control and Complications Trial Epidemiology of Diabetes Interventions and Complications Research Group: Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus. N Engl J Med. 2003, 348: 2294-2303.CrossRefPubMed

15.

Polak JF, Backlund JY, Cleary PA, Harrington AP, O'Leary DH, Lachin JM, Nathan DM, DCCT/EDIC Research Group: Progression of carotid artery intima-media thickness during 12 years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. Diabetes. 2011, 60: 607-613. 10.2337/db10-0296.PubMedCentralCrossRefPubMed

16.

Cleary PA, Orchard TJ, Genuth S, Wong ND, Detrano R, Backlund JY, Zinman B, Jacobson A, Sun W, Lachin JM, Nathan DM, DCCT/EDIC Research Group: The effect of intensive glycemic treatment on coronary artery calcification in type 1 diabetic participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study. Diabetes. 2006, 55: 3556-3565. 10.2337/db06-0653.PubMedCentralCrossRefPubMed

17.

UK Prospective Diabetes Study Group: Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998, 352: 837-853.CrossRef

18.

The Scandinavian Simvastatin Survival Study Group: Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4 S). Lancet. 1994, 344: 1383-1389.

19.

Pedersen TR, Wilhelmsen L, Faergeman O, Strandberg TE, Thorgeirsson G, Troedsson L, Kristianson J, Berg K, Cook TJ, Haghfelt T, Kjekshus J, Miettinen T, Olsson AG, Pyörälä K, Wedel H: Follow-up study of patients randomized in the Scandinavian simvastatin survival study (4 S) of cholesterol lowering. Am J Cardiol. 2000, 86: 257-262. 10.1016/S0002-9149(00)00910-3.CrossRefPubMed

20.

Strandberg TE, Pyörälä K, Cook TJ, Wilhelmsen L, Faergeman O, Thorgeirsson G, Pedersen TR, Kjekshus J: Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4 S). Lancet. 2004, 364: 771-777. 10.1016/S0140-6736(04)16936-5.CrossRefPubMed

21.

Heart Protection Study Collaborative Group: MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002, 360: 7-22.CrossRef

22.

Heart Protection Study Collaborative Group: Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20,536 high-risk individuals: a randomised controlled trial. Lancet. 2011, 378: 2013-2020.PubMedCentralCrossRef

23.

Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, McKillop JH, Packard CJ: Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med. 1995, 333: 1301-1307. 10.1056/NEJM199511163332001.CrossRefPubMed

24.

Ford I, Murray H, Packard CJ, Shepherd J, Macfarlane PW, Cobbe SM: Long-term follow-up of the West of Scotland Coronary Prevention Study. N Engl J Med. 2007, 357: 1477-1486. 10.1056/NEJMoa065994.CrossRefPubMed

25.

The long-term intervention with pravastatin in ischaemic disease (LIPID) study group: Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med. 1998, 339: 1349-1357.CrossRef

26.

The long-term intervention with pravastatin in ischaemic disease (LIPID) study group: Long-term effectiveness and safety of pravastatin in 9014 patients with coronary heart disease and average cholesterol concentrations: the LIPID trial follow-up. Lancet. 2002, 359: 1379-1387. Erratum: Lancet 2002, 360:1430CrossRef

27.

Sever PS, Dahlöf B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J, ASCOT investigators: Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet. 2003, 361: 1149-1158. 10.1016/S0140-6736(03)12948-0.CrossRefPubMed

28.

Sever PS, Poulter NR, Dahlof B, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes G, Mehlsen J, Nieminen MS, O'Brien ET, Ostergren J, ASCOT Investigators: The Anglo-Scandinavian Cardiac Outcomes Trial lipid lowering arm: extended observations 2 years after trial closure. Eur Heart J. 2008, 29: 499-508. 10.1093/eurheartj/ehm583.CrossRefPubMed

29.

Sever PS, Chang CL, Gupta AK, Whitehouse A, Poulter NR, ASCOT Investigators: The Anglo-Scandinavian Cardiac Outcomes Trial: 11-year mortality follow-up of the lipid-lowering arm in the U.K. Eur Heart J. 2011, 32: 2525-2532. 10.1093/eurheartj/ehr333.CrossRefPubMed

30.

The Heart Outcomes Prevention Evaluation Study Investigators: Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med. 2000, 342: 145-153.CrossRef

31.

Bosch J, Lonn E, Pogue J, Arnold MO, Dagenais GR, Yusuf S, HOPE/HOPE-TOO Study Investigators: Long-term effects of ramipril on cardiovascular events and on diabetes. Results of the HOPE Study Extension. Circulation. 2005, 112: 1339-1346.CrossRefPubMed

32.

Køber L, Torp-Pedersen C, Carlsen JE, Bagger H, Eliasen P, Lyngborg K, Videbaek J, Cole DS, Auclert L, Pauly NC: A clinical trial of the angiotensin-converting-enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction. Trandolapril Cardiac Evaluation (TRACE) Study Group. N Engl J Med. 1995, 333: 1670-1676. 10.1056/NEJM199512213332503.CrossRefPubMed

33.

Buch P, Rasmussen S, Abildstrom SZ, Køber L, Carlsen J, Torp-Pedersen C: The long-term impact of the angiotensin-converting enzyme inhibitor trandolapril on mortality and hospital admissions in patients with left ventricular dysfunction after a myocardial infarction: follow-up to 12 years. Eur Heart J. 2005, 26: 145-152.CrossRefPubMed

34.

The SOLVD Investigators: Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med. 1992, 327: 685-691. Erratum in: N Engl J Med 1992, 327:1768CrossRef

35.

Jong P, Yusuf S, Rousseau MF, Ahn SA, Bangdiwala SI: Effect of enalapril on 12-year survival and life expectancy in patients with left ventricular systolic dysfunction: a follow-up study. Lancet. 2003, 361: 1843-1848. 10.1016/S0140-6736(03)13501-5.CrossRefPubMed

36.

Staessen JA, Thijisq L, Fagard R, Celis H, Birkenhäger WH, Bulpitt CJ, de Leeuw PW, Fletcher AE, Forette F, Leonetti G, McCormack P, Nachev C, O'Brien E, Rodicio JL, Rosenfeld J, Sarti C, Tuomilehto J, Webster J, Yodfat Y, Zanchetti A: Systolic Hypertension in Europe (Syst-Eur) Trial Investigators: Effects of immediate versus delayed antihypertensive therapy on outcome in the Systolic Hypertension in Europe Trial. J Hypertens. 2004, 22: 847-857. 10.1097/00004872-200404000-00029.CrossRefPubMed

37.

UK Prospective Diabetes Study Group: Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. Br Med J. 1998, 317: 703-713. 10.1136/bmj.317.7160.703.CrossRef

38.

Holman RR, Paul SK, Bethel MA, Neil HA, Matthews DR: Long-term follow-up after tight control of blood pressure in type 2 diabetes. N Engl J Med. 2008, 359: 1565-1576. 10.1056/NEJMoa0806359.CrossRefPubMed

39.

Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M, Finnish Diabetes Prevention Study Group: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001, 344: 1343-1350. 10.1056/NEJM200105033441801.CrossRefPubMed

40.

Lindström J, Ilanne-Parikka P, Peltonen M, Aunola S, Eriksson JG, Hemiö K, Hämäläinen H, Härkönen P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Mannelin M, Paturi M, Sundvall J, Valle TT, Uusitupa M, Tuomilehto J, Finnish Diabetes Prevention Study Group: Sustained reduction in the incidence of type 2 diabetes by lifestyle-intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet. 2006, 368: 1673-1679. 10.1016/S0140-6736(06)69701-8.CrossRefPubMed

41.

Uusitupa M, Peltonen M, Lindström J, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Valle TT, Eriksson JG, Tuomilehto J, Finnish Diabetes Prevention Study Group: Ten-year mortality and cardiovascular morbidity in the Finnish Diabetes Prevention Study–secondary analysis of the randomized trial. PLoS One. 2009, 4: e5656-10.1371/journal.pone.0005656.PubMedCentralCrossRefPubMed

42.

Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, Hu ZX, Lin J, Xiao JZ, Cao HB, Liu PA, Jiang XG, Jiang YY, Wang JP, Zheng H, Zhang H, Bennett PH, Howard BV: Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the Da Qing IGT and Diabetes Study. Diabetes Care. 1997, 20: 537-544. 10.2337/diacare.20.4.537.CrossRefPubMed

43.

Li G, Zhang P, Wang J, Gregg EW, Yang W, Gong Q, Li H, Li H, Jiang Y, An Y, Shuai Y, Zhang B, Zhang J, Thompson TJ, Gerzoff RB, Roglic G, Hu Y, Bennett PH: The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet. 2008, 371: 1783-1789. 10.1016/S0140-6736(08)60766-7.CrossRefPubMed

44.

Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM, Diabetes Prevention Program Research Group: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002, 346: 393-403.CrossRefPubMed

45.

Knowler WC, Fowler SE, Hamman RF, Christophi CA, Hoffman HJ, Brenneman AT, Brown-Friday JO, Goldberg R, Venditti E, Nathan DM, Diabetes Prevention Program Research Group: 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet. 2009, 374: 1677-1686. 10.1016/S0140-6736(09)61457-4.CrossRefPubMed

46.

Gaede P, Vedel P, Larsen N, Jensen GVH, Parving H-H, Pedersen O: Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med. 2003, 348: 383-393. 10.1056/NEJMoa021778.CrossRefPubMed

47.

Gaede P, Lund-Andersen H, Parving HH, Pedersen O: Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med. 2008, 358: 580-591. 10.1056/NEJMoa0706245.CrossRefPubMed

48.

Yamagishi S, Nakamura K, Imaizumi T: Advanced glycation end products (AGEs) and diabetic vascular complications. Curr Diabetes Rev. 2005, 1: 93-106. 10.2174/1573399052952631.CrossRefPubMed

49.

Yamagishi S, Ueda S, Matsui T, Nakamura K, Okuda S: Role of advanced glycation end products (AGEs) and oxidative stress in diabetic retinopathy. Curr Pharm Des. 2008, 14: 962-968. 10.2174/138161208784139729.CrossRefPubMed

50.

Yan SF, Ramasamy R, Bucciarelli LG, Wendt T, Lee LK, Hudson BI, Stern DM, Lalla E, DU Yan S, Rong LL, Naka Y, Schmidt AM: RAGE and its ligands: a lasting memory in diabetic complications?. Diab Vasc Dis Res. 2004, 1: 10-20. 10.3132/dvdr.2004.001.CrossRefPubMed

51.

Ihnat MA, Thorpe JE, Kamat CD, Szabó C, Green DE, Warnke LA, Lacza Z, Cselenyák A, Ross K, Shakir S, Piconi L, Kaltreider RC, Ceriello A: Reactive oxygen species mediate a cellular “memory” of high glucose stress signalling. Diabetologia. 2007, 50: 1523-1531. 10.1007/s00125-007-0684-2.CrossRefPubMed

52.

El-Osta A, Brasacchio D, Yao D, Pocai A, Jones PL, Roeder RG, Cooper ME, Brownlee M: Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med. 2008, 205: 2409-2417. 10.1084/jem.20081188. Erratum in: J Exp Med 2008, 205:2683PubMedCentralCrossRefPubMed

53.

Siebel AL, Fernandez AZ, El-Osta A: Glycemic memory associated epigenetic changes. Biochem Pharmacol. 2010, 80: 1853-1859. 10.1016/j.bcp.2010.06.005.CrossRefPubMed

54.

Pirola L, Balcerczyk A, Okabe J, El-Osta A: Epigenetic phenomena linked to diabetic complications. Nat Rev Endocrinol. 2010, 6: 665-675. 10.1038/nrendo.2010.188.CrossRefPubMed

55.

Villeneuve LM, Natarajan R: The role of epigenetics in the pathology of diabetic complications. Am J Physiol Renal Physiol. 2010, 299: F14-F25. 10.1152/ajprenal.00200.2010.PubMedCentralCrossRefPubMed

56.

Reddy MA, Natarajan R: Epigenetic mechanisms in diabetic vascular complications. Cardiovasc Res. 2011, 90: 421-429. 10.1093/cvr/cvr024.PubMedCentralCrossRefPubMed

57.

Villeneuve LM, Natarajan R: Epigenetic mechanisms. Contrib Nephrol. 2011, 170: 57-65.CrossRefPubMed

58.

Schisano B, Tripathi G, McGee K, McTernan PG, Ceriello A: Glucose oscillations, more than constant high glucose, induce p53 activation and a metabolic memory in human endothelial cells. Diabetologia. 2011, 54: 1219-1226. 10.1007/s00125-011-2049-0.CrossRefPubMed

59.

Genuth S, Sun W, Cleary P, Sell DR, Dahms W, Malone J, Sivitz W, Monnier VM, DCCT Skin Collagen Ancillary Study Group: Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes control and complications trial and epidemiology of diabetes interventions and complications participants with type 1 diabetes. Diabetes. 2005, 54: 3103-3111. 10.2337/diabetes.54.11.3103.PubMedCentralCrossRefPubMed

60.

Lind M, Odén A, Fahlén M, Eliasson B: The shape of the metabolic memory of HbA1c: re-analysing the DCCT with respect to time-dependent effects. Diabetologia. 2010, 53: 1093-1098. 10.1007/s00125-010-1706-z.CrossRefPubMed

61.

Jax TW: Metabolic memory: a vascular perspective. Cardiovasc Diabetol. 2010, 9: 51-10.1186/1475-2840-9-51.PubMedCentralCrossRefPubMed

62.

Liao JK: Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition beyond low-density lipoprotein cholesterol. Am J Cardiol. 2005, 96 (5A): 24F-33F.PubMedCentralCrossRefPubMed

63.

Elrod JW, Lefer DJ: The effects of statins on endothelium, inflammation and cardioprotection. Drug News Perspect. 2005, 18: 229-236. 10.1358/dnp.2005.18.4.908656.CrossRefPubMed

64.

Parati G, Bilo G, Ochoa JE: Benefits of tight blood pressure control in diabetic patients with hypertension: importance of early and sustained implementation of effective treatment strategies. Diabetes Care. 2011, 34 (Suppl 2): S297-S303.PubMedCentralCrossRefPubMed

65.

Mancia G, Laurent S, Agabiti-Rosei E, Ambrosioni E, Burnier M, Caulfield MJ, Cifkova R, Clément D, Coca A, Dominiczak A, Erdine S, Fagard R, Farsang C, Grassi G, Haller H, Heagerty A, Kjeldsen SE, Kiowski W, Mallion JM, Manolis A, Narkiewicz K, Nilsson P, Olsen MH, Rahn KH, Redon J, Rodicio J, Ruilope L, Schmieder RE, Struijker-Boudier HA, van Zwieten PA, Viigimaa M, Zanchetti A: Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. J Hypertens. 2009, 27: 2121-2158. 10.1097/HJH.0b013e328333146d.CrossRefPubMed

66.

Ismail H, Mitchell R, McFarlane SI, Makaryus AN: Pleiotropic effects of inhibitors of the RAAS in the diabetic population: above and beyond blood pressure lowering. Curr Diab Rep. 2010, 10: 32-36. 10.1007/s11892-009-0081-y.CrossRefPubMed

67.

Volpe M, Cosentino F, Tocci G, Palano F, Paneni F: Antihypertensive therapy in diabetes: the legacy effect and RAAS blockade. Curr Hypertens Rep. 2011, 13: 318-324. 10.1007/s11906-011-0205-z.CrossRefPubMed

68.

Uusitupa M, Lindi V, Louheranta A, Salopuro T, Lindström J, Tuomilehto J, Finnish Diabetes Prevention Study Group: Long-term improvement in insulin sensitivity by changing lifestyles of people with impaired glucose tolerance: 4-year results from the Finnish Diabetes Prevention Study. Diabetes. 2003, 52: 2532-2538. 10.2337/diabetes.52.10.2532.CrossRefPubMed

69.

de Mello VD, Lindström J, Eriksson J, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Sundvall J, Laakso M, Tuomilehto J, Uusitupa M: Insulin secretion and its determinants in the progression of impaired glucose tolerance to type 2 diabetes in impaired glucose-tolerant individuals: the Finnish Diabetes Prevention Study. Diabetes Care. 2012, 35: 211-217. 10.2337/dc11-1272.PubMedCentralCrossRefPubMed

70.

Ihnat MA, Thorpe JE, Ceriello A: Hypothesis: the „metabolic memory”, the new challenge of diabetes. Diabet Med. 2007, 24: 582-586. 10.1111/j.1464-5491.2007.02138.x.CrossRefPubMed

71.

Ceriello A: Hypothesis: the „metabolic memory”, the new challenge of diabetes. Diabetes Res Clin Pract. 2009, 86S: S2-S6.CrossRef

72.

Jermendy G: Late effect of treatment for reducing cardiovascular risk – a hypothesis on cardiometabolic therapeutic memory. Med Hypotheses. 2009, 73: 73-79. 10.1016/j.mehy.2009.01.034.CrossRefPubMed

73.

Del Prato S: Megatrials in type 2 diabetes. From excitement to frustration?. Diabetologia. 2009, 52: 1219-1226. 10.1007/s00125-009-1352-5.CrossRefPubMed

74.

Griffin SJ, Borch-Johnsen K, Davies MJ, Khunti K, Rutten GE, Sandbæk A, Sharp SJ, Simmons RK, van den Donk M, Wareham NJ, Lauritzen T: Effect of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with type 2 diabetes detected by screening (ADDITION-Europe): a cluster-randomised trial. Lancet. 2011, 378: 156-167. 10.1016/S0140-6736(11)60698-3.PubMedCentralCrossRefPubMed

Title: Vascular memory: can we broaden the concept of the metabolic memory?
Author: György Jermendy
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Cardiovascular Diabetology / Issue 1/2012
Electronic ISSN: 1475-2840
DOI: https://doi.org/10.1186/1475-2840-11-44

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