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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2013

Open Access 01-12-2013 | Research article

Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat

Authors: Salem S Al-Rejaie, Abdulaziz M Aleisa, Mohamed M Sayed-Ahmed, Othman A AL-Shabanah, Hatem M Abuohashish, Mohammed M Ahmed, Khaled A Al-Hosaini, Mohamed M Hafez

Published in: BMC Complementary Medicine and Therapies | Issue 1/2013

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Abstract

Background

High-cholesterol diet (HCD) increases the oxidative stress in different tissues leading to many diseases. Rutin (RT) is a natural flavonoid (vitamin p), which possesses an antioxidant activity with protective potential. The present study aimed to examine the potential effects of rutin on hypercholesterolemia-induced hepatotoxicity in rat.

Methods

Male Wistar rats were divided into four groups: GI) control (Rat chow), GII) Rutin (0.2% in rat chow), GIII) HCD (1% cholesterol and 0.5% cholic acid in rat chow) and GIV) rutin (0.2%) + HCD.

Results

Rutin in combination with HCD induced a significant protective effect against the hepatotoxicity by reducing the plasma level of alanine transaminase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL). The HCD (GII) showed a decrease in glutathione peroxidase (GPx), glutathione reductase (GR) and increase in glutathione S transferase α (GSTα), sulfiredoxin-1(Srx1), glutamate-cysteine ligase (GCL) and paraoxonase-1(PON-1) genes expression levels.

Conclusion

Treatment with rutin reversed all the altered genes induced by HCD nearly to the control levels. The present study concluded that the HCD feedings altered the expression levels of some genes involved in the oxidative stress pathway resulting in DNA damage and hepatotoxicity. Rutin have a hepatoprotective effect through the mechanism of enhancing the antioxidant effect via amelioration of oxidative stress genes.
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Literature
1.
Farrell GC, Teoh NC, McCuskey RS: Hepatic microcirculation in fatty liver disease. Anat Rec (Hoboken). 2008, 291: 684-692. 10.1002/ar.20715.CrossRef
2.
Trauner M, Arrese M, Wagner M: Fatty liver and lipotoxicity. Biochim Biophys Acta. 1801, 2010: 299-310.
3.
Bellentani S, Saccoccio G, Masutti F, Croce LS, Brandi G, Sasso F, Cristanini G, Tiribelli C: Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med. 2000, 132: 112-117.CrossRefPubMed
4.
Vitaglione P, Morisco F, Mazzone G, Amoruso DC, Ribecco MT, Romano A, Fogliano V, Caporaso N, D'Argenio G: Coffee reduces liver damage in a rat model of steatohepatitis: the underlying mechanisms and the role of polyphenols and melanoidins. Hepatology. 2010, 52: 1652-1661. 10.1002/hep.23902.CrossRefPubMed
5.
Araya J, Rodrigo R, Videla LA, Thielemann L, Orellana M, Pettinelli P, Poniachik J: Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin Sci (Lond). 2004, 106: 635-643. 10.1042/CS20030326.CrossRef
6.
Araya J, Rodrigo R, Pettinelli P, Araya AV, Poniachik J, Videla LA: Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients. Obesity (Silver Spring). 2010, 18: 1460-1463. 10.1038/oby.2009.379.CrossRef
7.
Videla LA, Rodrigo R, Araya J, Poniachik J: Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease. Trends Mol Med. 2006, 12: 555-558. 10.1016/j.molmed.2006.10.001.CrossRefPubMed
8.
Tomofuji T, Azuma T, Kusano H, Sanbe T, Ekuni D, Tamaki N, Yamamoto T, Watanabe T: Oxidative damage of periodontal tissue in the rat periodontitis model: effects of a high-cholesterol diet. FEBS Lett. 2006, 580: 3601-3604. 10.1016/j.febslet.2006.05.041.CrossRefPubMed
9.
Fried M, Hainer V, Basdevant A, Buchwald H, Dietel M, Finer N, Greve JW, Horber F, Mathus-Vliegen E, Scopinaro N: Interdisciplinary European guidelines on surgery for severe obesity. Rozhl Chir. 2008, 87: 468-476.PubMed
10.
Preiss D, Sattar N: Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations. Clin Sci (Lond). 2008, 115: 141-150. 10.1042/CS20070402.CrossRef
11.
Al-Nozha MM, Al-Mazrou YY, Al-Maatouq MA, Arafah MR, Khalil MZ, Khan NB, Al-Marzouki K, Abdullah MA, Al-Khadra AH, Al-Harthi SS: Obesity in Saudi Arabia. Saudi Med J. 2005, 26: 824-829.PubMed
12.
Al-hamoudi W, El-Sabbah M, Ali S, Altuwaijri M, Bedewi M, Adam M, Alhammad A, Sanai F, Alswat K, Abdo A: Epidemiological, clinical, and biochemical characteristics of Saudi patients with nonalcoholic fatty liver disease: a hospital-based study. Ann Saudi Med. 2012, 32: 288-292.PubMed
13.
14.
Clarke SD, Jump DB: Polyunsaturated fatty acid regulation of hepatic gene transcription. Lipids. 1996, 31 (Suppl): S7-S11.CrossRefPubMed
15.
Pegorier JP, Le May C, Girard J: Control of gene expression by fatty acids. J Nutr. 2004, 134: 2444S-2449S.PubMed
16.
Nguyen P, Leray V, Diez M, Serisier S, Le Bloc'h J, Siliart B, Dumon H: Liver lipid metabolism. J Anim Physiol Anim Nutr. 2008, 92: 272-283. 10.1111/j.1439-0396.2007.00752.x.CrossRef
17.
Ikonen E: Mechanisms for cellular cholesterol transport: defects and human disease. Physiol Rev. 2006, 86: 1237-1261. 10.1152/physrev.00022.2005.CrossRefPubMed
18.
Ho YK, Brown MS, Goldstein JL: Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages: stimulation by high density lipoprotein and other agents. J Lipid Res. 1980, 21: 391-398.PubMed
19.
Sonta T, Inoguchi T, Tsubouchi H, Sekiguchi N, Kobayashi K, Matsumoto S, Utsumi H, Nawata H: Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity. Free Radic Biol Med. 2004, 37: 115-123. 10.1016/j.freeradbiomed.2004.04.001.CrossRefPubMed
20.
Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I: Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004, 114: 1752-1761.CrossRefPubMedPubMedCentral
21.
Faienza MF, Francavilla R, Goffredo R, Ventura A, Marzano F, Panzarino G, Marinelli G, Cavallo L, Di Bitonto G: Oxidative stress in obesity and metabolic syndrome in children and adolescents. Horm Res Paediatr. 2012, 78: 158-164. 10.1159/000342642.CrossRefPubMed
22.
Park S, Kim M, Paik JK, Jang YJ, Lee SH, Lee JH: Oxidative stress is associated with C-reactive protein in non-diabetic postmenopausal women, independent of obesity and insulin resistance. Clin Endocrinol (Oxf). 2012, 79: 65-70.CrossRef
23.
Mishra KP: Cell membrane oxidative damage induced by gamma-radiation and apoptotic sensitivity. J Environ Pathol Toxicol Oncol. 2004, 23: 61-66. 10.1615/JEnvPathToxOncol.v23.i1.60.CrossRefPubMed
24.
Bravo E, Palleschi S, Aspichueta P, Buque X, Rossi B, Cano A, Napolitano M, Ochoa B, Botham KM: High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway. Lipids Health Dis. 2011, 10: 60-10.1186/1476-511X-10-60.CrossRefPubMedPubMedCentral
25.
Koc A, Duru M, Ciralik H, Akcan R, Sogut S: Protective agent, erdosteine, against cisplatin-induced hepatic oxidant injury in rats. Mol Cell Biochem. 2005, 278: 79-84. 10.1007/s11010-005-6630-z.CrossRefPubMed
26.
Blokhina O, Virolainen E, Fagerstedt KV: Antioxidants, oxidative damage and oxygen deprivation stress: a review. Ann Bot. 2003, 91: Spec No:179-Spec No:194.CrossRefPubMed
27.
Yagmurca M, Bas O, Mollaoglu H, Sahin O, Nacar A, Karaman O, Songur A: Protective effects of erdosteine on doxorubicin-induced hepatotoxicity in rats. Arch Med Res. 2007, 38: 380-385. 10.1016/j.arcmed.2007.01.007.CrossRefPubMed
28.
Sayed-Ahmed AMA MM, Al-Rejaie SS, Al-Yahya AA, Al-Shabanah OA, Hafez MM, Nagi MN: Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling. Oxidative Medicine and Cellular Longevity. 2010, 3: 254-261. 10.4161/oxim.3.4.12714.CrossRef
29.
Danz ED, Skramsted J, Henry N, Bennett JA, Keller RS: Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway. Free Radic Biol Med. 2009, 46: 1589-1597. 10.1016/j.freeradbiomed.2009.03.011.CrossRefPubMed
30.
Fisher-Wellman K, Bell HK, Bloomer RJ: Oxidative stress and antioxidant defense mechanisms linked to exercise during cardiopulmonary and metabolic disorders. Oxid Med Cell Longev. 2009, 2: 43-51. 10.4161/oxim.2.1.7732.CrossRefPubMedPubMedCentral
31.
Senti M, Tomas M, Fito M, Weinbrenner T, Covas MI, Sala J, Masia R, Marrugat J: Antioxidant paraoxonase 1 activity in the metabolic syndrome. J Clin Endocrinol Metab. 2003, 88: 5422-5426. 10.1210/jc.2003-030648.CrossRefPubMed
32.
Peltoniemi MJ, Rytila PH, Harju TH, Soini YM, Salmenkivi KM, Ruddock LW, Kinnula VL: Modulation of glutaredoxin in the lung and sputum of cigarette smokers and chronic obstructive pulmonary disease. Respir Res. 2006, 7: 133-10.1186/1465-9921-7-133.CrossRefPubMedPubMedCentral
33.
Lu W, Chen Z, Zhang H, Wang Y, Luo Y, Huang P: ZNF143 transcription factor mediates cell survival through upregulation of the GPX1 activity in the mitochondrial respiratory dysfunction. Cell Death Dis. 2012, 3: e422-10.1038/cddis.2012.156.CrossRefPubMedPubMedCentral
34.
Potter JD: Cancer prevention: epidemiology and experiment. Cancer Lett. 1997, 114: 7-9. 10.1016/S0304-3835(97)04615-6.CrossRefPubMed
35.
Aleksandrov PN, Speranskaia TV, Bobkov Iu G, Zagorevskii VA, Zykov DA: [Effect of rutin and esculamine on models of aseptic inflammation]. Farmakol Toksikol. 1986, 49: 84-86.PubMed
36.
Deschner EE, Ruperto J, Wong G, Newmark HL: Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis. 1991, 12: 1193-1196. 10.1093/carcin/12.7.1193.CrossRefPubMed
37.
Bear WL, Teel RW: Effects of citrus flavonoids on the mutagenicity of heterocyclic amines and on cytochrome P450 1A2 activity. Anticancer Res. 2000, 20: 3609-3614.PubMed
38.
Chen S, Gong J, Liu F, Mohammed U: Naturally occurring polyphenolic antioxidants modulate IgE-mediated mast cell activation. Immunology. 2000, 100: 471-480. 10.1046/j.1365-2567.2000.00045.x.CrossRefPubMedPubMedCentral
39.
Khan RA, Khan MR, Sahreen S: CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat. BMC Complement Altern Med. 2012, 12: 178-10.1186/1472-6882-12-178.CrossRefPubMedPubMedCentral
40.
Lopez-Revuelta A, Sanchez-Gallego JI, Hernandez-Hernandez A, Sanchez-Yague J, Llanillo M: Membrane cholesterol contents influence the protective effects of quercetin and rutin in erythrocytes damaged by oxidative stress. Chem Biol Interact. 2006, 161: 79-91. 10.1016/j.cbi.2006.03.004.CrossRefPubMed
41.
Takashi N, Nobuaki T, Yoshiaki I, Naoyuki N: Suppression of early and advanced glycation by dietary water-soluble rutin derivative in diabetic rats. Int Congr Ser. 2002, 1245: 403-405.CrossRef
42.
Al-Rejaie SS, Abuohashish HM, Alkhamees OA, Aleisa AM, Alroujayee AS: Gender difference following high cholesterol diet induced renal injury and the protective role of rutin and ascorbic acid combination in Wistar albino rats. Lipids Health Dis. 2012, 11: 41-10.1186/1476-511X-11-41.CrossRefPubMedPubMedCentral
43.
Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979, 95: 351-358. 10.1016/0003-2697(79)90738-3.CrossRefPubMed
44.
Sedlak J, Lindsay RH: Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 1968, 25: 192-205.CrossRefPubMed
45.
Sayed-Ahmed MM, Al-Shabanah OA, Hafez MM, Aleisa AM, Al-Rejaie SS: Inhibition of gene expression of heart fatty acid binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model. Eur J Pharmacol. 2010, 640: 143-149. 10.1016/j.ejphar.2010.05.002.CrossRefPubMed
46.
Artham SM, Lavie CJ, Milani RV, Ventura HO: The obesity paradox: impact of obesity on the prevalence and prognosis of cardiovascular diseases. Postgrad Med. 2008, 120: 34-41. 10.3810/pgm.2008.07.1788.CrossRefPubMed
47.
Madsen AN, Hansen G, Paulsen SJ, Lykkegaard K, Tang-Christensen M, Hansen HS, Levin BE, Larsen PJ, Knudsen LB, Fosgerau K: Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome. J Endocrinol. 2010, 206: 287-296. 10.1677/JOE-10-0004.CrossRefPubMed
48.
Lopez IP, Marti A, Milagro FI, Zulet Md Mde L, Moreno-Aliaga MJ, Martinez JA, De Miguel C: DNA microarray analysis of genes differentially expressed in diet-induced (cafeteria) obese rats. Obes Res. 2003, 11: 188-194. 10.1038/oby.2003.30.CrossRefPubMed
49.
Tan M, Schmidt RH, Beier JI, Watson WH, Zhong H, States JC, Arteel GE: Chronic subhepatotoxic exposure to arsenic enhances hepatic injury caused by high fat diet in mice. Toxicol Appl Pharmacol. 2011, 257: 356-364. 10.1016/j.taap.2011.09.019.CrossRefPubMedPubMedCentral
50.
Song HY, Mao ZM, Yang LL, Liu T, Li DF, Zhang L, Ge YL, Zheng PY, Liu P, Zhang XQ: Dangfei liganning capsules attenuate the susceptibility of rat nonalcoholic fatty liver to carbon tetrachloride toxicity. J Tradit Chin Med. 2011, 31: 327-333. 10.1016/S0254-6272(12)60013-2.CrossRefPubMed
51.
Kamalakkannan N, Prince PS: Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats. Basic Clin Pharmacol Toxicol. 2006, 98: 97-103. 10.1111/j.1742-7843.2006.pto_241.x.CrossRefPubMed
52.
Kamalakkannan N, Stanely Mainzen Prince P: Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues. Mol Cell Biochem. 2006, 293: 211-219. 10.1007/s11010-006-9244-1.CrossRefPubMed
53.
Tsimikas S, Miller YI: Oxidative modification of lipoproteins: mechanisms, role in inflammation and potential clinical applications in cardiovascular disease. Curr Pharm Des. 2011, 17: 27-37. 10.2174/138161211795049831.CrossRefPubMed
54.
Lavie L, Lavie P: Molecular mechanisms of cardiovascular disease in OSAHS: the oxidative stress link. Eur Respir J. 2009, 33: 1467-1484. 10.1183/09031936.00086608.CrossRefPubMed
55.
Noeman SA, Hamooda HE, Baalash AA: Biochemical study of oxidative stress markers in the liver, kidney and heart of high fat diet induced obesity in rats. Diabetol Metab Syndr. 2011, 3: 17-10.1186/1758-5996-3-17.CrossRefPubMedPubMedCentral
56.
Amin KA, Nagy MA: Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats. Diabetol Metab Syndr. 2009, 1: 17-10.1186/1758-5996-1-17.CrossRefPubMedPubMedCentral
57.
Bloomgarden ZT: Dyslipidemia and the metabolic syndrome. Diabetes Care. 2004, 27: 3009-3016. 10.2337/diacare.27.12.3009.CrossRefPubMed
58.
Kauss T, Moynet D, Rambert J, Al-Kharrat A, Brajot S, Thiolat D, Ennemany R, Fawaz F, Mossalayi MD: Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis. Arthritis Res Ther. 2008, 10: R19-10.1186/ar2372.CrossRefPubMedPubMedCentral
59.
Guardia T, Rotelli AE, Juarez AO, Pelzer LE: Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco. 2001, 56: 683-687. 10.1016/S0014-827X(01)01111-9.CrossRefPubMed
60.
Ziaee A, Zamansoltani F, Nassiri-Asl M, Abbasi E: Effects of rutin on lipid profile in hypercholesterolaemic rats. Basic Clin Pharmacol Toxicol. 2009, 104: 253-258. 10.1111/j.1742-7843.2008.00368.x.CrossRefPubMed
61.
Park S, Park NY, Valacchi G, Lim Y: Calorie restriction with a high-fat diet effectively attenuated inflammatory response and oxidative stress-related markers in obese tissues of the high diet fed rats. Mediators Inflamm. 2012, 2012: 984643-CrossRefPubMedPubMedCentral
62.
Huisamen B, Dietrich D, Bezuidenhout N, Lopes J, Flepisi B, Blackhurst D, Lochner A: Early cardiovascular changes occurring in diet-induced, obese insulin-resistant rats. Mol Cell Biochem. 2012, 368: 37-45. 10.1007/s11010-012-1340-9.CrossRefPubMed
63.
Vincent HK, Powers SK, Dirks AJ, Scarpace PJ: Mechanism for obesity-induced increase in myocardial lipid peroxidation. Int J Obes Relat Metab Disord. 2001, 25: 378-388. 10.1038/sj.ijo.0801536.CrossRefPubMed
64.
Husain K, Somani SM: Interaction of exercise training and chronic ethanol ingestion on hepatic and plasma antioxidant system in rat. J Appl Toxicol. 1997, 17: 189-194. 10.1002/(SICI)1099-1263(199705)17:3<189::AID-JAT431>3.0.CO;2-7.CrossRefPubMed
65.
Ji L, Liu T, Chen Y, Wang Z: Protective mechanisms of N-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicity. J Cell Biochem. 2009, 108: 424-432. 10.1002/jcb.22269.CrossRefPubMed
66.
Chen L, Pan DD, Zhou J, Jiang YZ: Protective effect of selenium-enriched Lactobacillus on CCl4-induced liver injury in mice and its possible mechanisms. World journal of gastroenterology : WJG. 2005, 11: 5795-5800.CrossRefPubMedPubMedCentral
67.
Sanz N, Diez-Fernandez C, Alvarez A, Cascales M: Age-dependent modifications in rat hepatocyte antioxidant defense systems. J Hepatol. 1997, 27: 525-534. 10.1016/S0168-8278(97)80358-3.CrossRefPubMed
68.
Kim SJ, Jung HJ, Hyun DH, Park EH, Kim YM, Lim CJ: Glutathione reductase plays an anti-apoptotic role against oxidative stress in human hepatoma cells. Biochimie. 2010, 92: 927-932. 10.1016/j.biochi.2010.03.007.CrossRefPubMed
69.
70.
Sekine Y, Osei-Hwedieh D, Matsuda K, Raghavachari N, Liu D, Furuya Y, Koike H, Suzuki K, Remaley AT: High fat diet reduces the expression of glutathione peroxidase 3 in mouse prostate. Prostate. 2011, 71: 1499-1509.PubMedPubMedCentral
71.
De Haan JB, Witting PK, Stefanovic N, Pete J, Daskalakis M, Kola I, Stocker R, Smolich JJ: Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet. J Lipid Res. 2006, 47: 1157-1167. 10.1194/jlr.M500377-JLR200.CrossRefPubMed
72.
Pradeep K, Mohan CV, Gobianand K, Karthikeyan S: Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats. Eur J Pharmacol. 2007, 560: 110-116. 10.1016/j.ejphar.2006.12.023.CrossRefPubMed
73.
Leviev I, Negro F, James RW: Two alleles of the human paraoxonase gene produce different amounts of mRNA. An explanation for differences in serum concentrations of paraoxonase associated with the (Leu-Met54) polymorphism. Arterioscler Thromb Vasc Biol. 1997, 17: 2935-2939. 10.1161/01.ATV.17.11.2935.CrossRefPubMed
74.
Rodrigo L, Gil F, Hernandez AF, Marina A, Vazquez J, Pla A: Purification and characterization of paraoxon hydrolase from rat liver. Biochem J. 1997, 321 (Pt 3): 595-601.CrossRefPubMedPubMedCentral
75.
Ferre N, Marsillach J, Camps J, Mackness B, Mackness M, Riu F, Coll B, Tous M, Joven J: Paraoxonase-1 is associated with oxidative stress, fibrosis and FAS expression in chronic liver diseases. J Hepatol. 2006, 45: 51-59. 10.1016/j.jhep.2005.12.018.CrossRefPubMed
76.
Zhang C, Peng W, Jiang X, Chen B, Zhu J, Zang Y, Zhang J, Zhu T, Qin J: Transgene expression of human PON1 Q in mice protected the liver against CCl4-induced injury. J Gene Med. 2008, 10: 94-100. 10.1002/jgm.1128.CrossRefPubMed
77.
Curin Y, Ritz MF, Andriantsitohaina R: Cellular mechanisms of the protective effect of polyphenols on the neurovascular unit in strokes. Cardiovasc Hematol Agents Med Chem. 2006, 4: 277-288. 10.2174/187152506778520691.CrossRefPubMed
78.
Panchal SK, Poudyal H, Arumugam TV, Brown L: Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats. J Nutr. 2011, 141: 1062-1069. 10.3945/jn.111.137877.CrossRefPubMed
79.
Findlay VJ, Tapiero H, Townsend DM: Sulfiredoxin: a potential therapeutic agent?. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2005, 59: 374-379. 10.1016/j.biopha.2005.07.003.CrossRef
80.
Rhee SG, Jeong W, Chang TS, Woo HA: Sulfiredoxin, the cysteine sulfinic acid reductase specific to 2-Cys peroxiredoxin: its discovery, mechanism of action, and biological significance. Kidney Int Suppl. 2007, S3-S8.
81.
Biteau B, Labarre J, Toledano MB: ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin. Nature. 2003, 425: 980-984. 10.1038/nature02075.CrossRefPubMed
82.
Martindale JL, Holbrook NJ: Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol. 2002, 192: 1-15. 10.1002/jcp.10119.CrossRefPubMed
83.
Maher P, Schubert D: Signaling by reactive oxygen species in the nervous system. Cell Mol Life Sci. 2000, 57: 1287-1305. 10.1007/PL00000766.CrossRefPubMed
84.
Feinendegen LE: Reactive oxygen species in cell responses to toxic agents. Hum Exp Toxicol. 2002, 21: 85-90. 10.1191/0960327102ht216oa.CrossRefPubMed
85.
Turella P, Cerella C, Filomeni G, Bullo A, De Maria F, Ghibelli L, Ciriolo MR, Cianfriglia M, Mattei M, Federici G: Proapoptotic activity of new glutathione S-transferase inhibitors. Cancer Res. 2005, 65: 3751-3761. 10.1158/0008-5472.CAN-04-3903.CrossRefPubMed
86.
Burg D, Riepsaame J, Pont C, Mulder G, van de Water B: Peptide-bond modified glutathione conjugate analogs modulate GSTpi function in GSH-conjugation, drug sensitivity and JNK signaling. Biochem Pharmacol. 2006, 71: 268-277. 10.1016/j.bcp.2005.11.003.CrossRefPubMed
87.
Nishiya T, Mori K, Hattori C, Kai K, Kataoka H, Masubuchi N, Jindo T, Manabe S: The crucial protective role of glutathione against tienilic acid hepatotoxicity in rats. Toxicol Appl Pharmacol. 2008, 232: 280-291. 10.1016/j.taap.2008.06.024.CrossRefPubMed
88.
Wu KC, Liu JJ, Klaassen CD: Nrf2 activation prevents cadmium-induced acute liver injury. Toxicol Appl Pharmacol. 2012, 263: 14-20. 10.1016/j.taap.2012.05.017.CrossRefPubMed
89.
Wang J, Ji L, Liu H, Wang Z: Study of the hepatotoxicity induced by Dioscorea bulbifera L. rhizome in mice. Biosci Trends. 2010, 4: 79-85.PubMed
90.
Baek JY, Han SH, Sung SH, Lee HE, Kim YM, Noh YH, Bae SH, Rhee SG, Chang TS: Sulfiredoxin protein is critical for redox balance and survival of cells exposed to low steady-state levels of H2O2. J Biol Chem. 2012, 287: 81-89. 10.1074/jbc.M111.316711.CrossRefPubMed
Metadata
Title
Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat
Authors
Salem S Al-Rejaie
Abdulaziz M Aleisa
Mohamed M Sayed-Ahmed
Othman A AL-Shabanah
Hatem M Abuohashish
Mohammed M Ahmed
Khaled A Al-Hosaini
Mohamed M Hafez
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2013
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/1472-6882-13-136

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