Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Medical Genetics
Published in: BMC Medical Genetics 1/2014

Open Access 01-12-2014 | Research article

CHI3L1polymorphisms associate with asthma in a Taiwanese population

Authors: Yishan Tsai, Yingchin Ko, Mingshyan Huang, Mengchih Lin, Chaochien Wu, Chinchou Wang, Yunxuan Chen, Jianing Li, Yuting Tseng, Tsunai Wang

Published in: BMC Medical Genetics | Issue 1/2014

Login to get access

Abstract

Background

A genome-wide association study uncovered Chitinase 3 like 1 (CHI3L1) as a candidate gene for asthma susceptibility. CHI3L1, which encodes the YKL-40 protein, is associated with asthma in Western European and American populations and with atopy in a Korean population. However, asthma-associated polymorphisms remain unknown for a Taiwanese population.

Methods

We enrolled 628 adult asthmatic patients and 1:1 age-sex matched community-based controls in southern Taiwan and performed a combined effect sizes analysis to test if CHI3L1 polymorphisms were related to genetic risks for asthma in the Asian population. Ten tagSNP polymorphisms for the CHI3L1 gene were selected from the HapMap database and genotyped using a TaqMan allelic discrimination assay.

Results

Adjusted odds ratios of the CHI3L1 rs1538372 CC genotype (aOR = 1.97, 95% CI: 1.23–3.14) and the rs10399931 GG genotype (aOR = 1.77, 95% CI: 1.13–2.77) were significantly associated with asthma in the Taiwanese populations. Predictive values of forced expiratory volume in the first second of the forced vital capacity (12.37%, P = 0.03) and of forced vital capacity (12.10%, P = 0.036) decreased in conjunction with an increase in YKL-40 levels among CHI3L1 rs1538372 CC carriers; these values were 16.1% (P = 0.004) and 14.5% (P = 0.011), respectively, among CHI3L1 rs10399931 GG carriers. Furthermore, steroid use by asthma patients did not affect serum YKL-40 levels, but both polymorphisms had significant effects on YKL-40 levels in asthma patients who used steroids.

Conclusions

Our findings suggest that the CHI3L1 polymorphisms rs1538372 and rs10399931 can be used as genetic markers for predicting asthma risk in the Taiwanese population.
Appendix
Available only for authorised users
Literature
1.
2.
Wills-Karp M, Ewart SL: Time to draw breath: asthma-susceptibility genes are identified. Nat Rev Genet. 2004, 5 (5): 376-387.CrossRefPubMed
3.
Siroux V, Boudier A, Anto JM, Cazzoletti L, Accordini S, Alonso J, Cerveri I, Corsico A, Gulsvik A, Jarvis D, de Marco R, Marcon A, Marques EA, Bugiani M, Janson C, Leynaert B, Pin I: Quality-of-life and asthma-severity in general population asthmatics: results of the ECRHS II study. Allergy. 2008, 63 (5): 547-554.CrossRefPubMed
4.
Lee CG, Da Silva CA, Lee JY, Hartl D, Elias JA: Chitin regulation of immune responses: an old molecule with new roles. Curr Opin Immunol. 2008, 20 (6): 684-689.CrossRefPubMedPubMedCentral
5.
Hakala BE, White C, Recklies AD: Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J Biol Chem. 1993, 268 (34): 25803-25810.PubMed
6.
Rehli M, Krause SW, Andreesen R: Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation. Genomics. 1997, 43 (2): 221-225.CrossRefPubMed
7.
Johansen JS: Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer. Dan Med Bull. 2006, 53 (2): 172-209.PubMed
8.
Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, Flavell RA, Elias JA: Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med. 2009, 206 (5): 1149-1166.CrossRefPubMedPubMedCentral
9.
Chupp GL, Lee CG, Jarjour N, Shim YM, Holm CT, He S, Dziura JD, Reed J, Coyle AJ, Kiener P, Cullen M, Grandsaigne M, Dombret MC, Aubier M, Pretolani M, Elias JA: A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med. 2007, 357 (20): 2016-2027.CrossRefPubMed
10.
Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF, Nicolae DL, Elias JA, Chupp GL: Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med. 2008, 358 (16): 1682-1691.CrossRefPubMedPubMedCentral
11.
Ober C, Chupp GL: The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases. Curr Opin Allergy Clin Immunol. 2009, 9 (5): 401-408.CrossRefPubMedPubMedCentral
12.
Rathcke CN, Holmkvist J, Husmoen LL, Hansen T, Pedersen O, Vestergaard H, Linneberg A: Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults. PLoS One. 2009, 4 (7): e6106-CrossRefPubMedPubMedCentral
13.
Sohn MH, Lee JH, Kim KW, Kim SW, Lee SH, Kim KE, Kim KH, Lee CG, Elias JA, Lee MG: Genetic variation in the promoter region of chitinase 3-like 1 is associated with atopy. Am J Respir Crit Care Med. 2009, 179 (6): 449-456.CrossRefPubMed
14.
Tang H, Fang Z, Sun Y, Li B, Shi Z, Chen J, Zhang T, Xiu Q: YKL-40 in asthmatic patients, and its correlations with exacerbation, eosinophils and immunoglobulin E. Eur Respir J. 2010, 35 (4): 757-760.CrossRefPubMed
15.
Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, Gibson P, Ohta K, O'Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ: Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008, 31 (1): 143-178.CrossRefPubMed
16.
Wang TN, Lin MC, Wu CC, Leung SY, Huang MS, Chuang HY, Lee CH, Wu DC, Ho PS, Ko AM, Chang PY, Ko YC: Risks of exposure to occupational asthmogens in atopic and nonatopic asthma: a case–control study in Taiwan. Am J Respir Crit Care Med. 2010, 182 (11): 1369-1376.CrossRefPubMed
17.
Society AT: Standardization of spirometry–1987 update. Statement of the American Thoracic Society. Am Rev Respir Dis. 1987, 136 (5): 1285-1298.CrossRef
18.
Verlaan DJ, Ouimet M, Adoue V, Sirois-Gagnon D, Lariviere M, Ge B, Beaulieu P, Dias J, Lam KC, Koka V, Laprise C, Pastinen T, Sinnett D: Promoter polymorphisms in CHI3L1 are associated with asthma. J Allergy Clin Immunol. 2012, 130 (2): 533-535.CrossRefPubMed
19.
Keatings VM, Jatakanon A, Worsdell YM, Barnes PJ: Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. Am J Respir Crit Care Med. 1997, 155 (2): 542-548.CrossRefPubMed
20.
Adcock IM, Caramori G: Cross-talk between pro-inflammatory transcription factors and glucocorticoids. Immunol Cell Biol. 2001, 79 (4): 376-384.CrossRefPubMed
21.
Neph S, Vierstra J, Stergachis AB, Reynolds AP, Haugen E, Vernot B, Thurman RE, John S, Sandstrom R, Johnson AK, Maurano MT, Humbert R, Rynes E, Wang H, Vong S, Lee K, Bates D, Diegel M, Roach V, Dunn D, Neri J, Schafer A, Hansen RS, Kutyavin T, Giste E, Weaver M, Canfield T, Sabo P, Zhang M, Balasundaram G, et al: An expansive human regulatory lexicon encoded in transcription factor footprints. Nature. 2012, 489 (7414): 83-90.CrossRefPubMedPubMedCentral
22.
23.
Sampath D, Castro M, Look DC, Holtzman MJ: Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma. J Clin Invest. 1999, 103 (9): 1353-1361.CrossRefPubMedPubMedCentral
24.
Wallace AD, Wheeler TT, Young DA: Inducibility of E4BP4 suggests a novel mechanism of negative gene regulation by glucocorticoids. Biochem Biophys Res Commun. 1997, 232 (2): 403-406.CrossRefPubMed
25.
Nikota JK, Botelho FM, Bauer CM, Jordana M, Coyle AJ, Humbles AA, Stampfli MR: Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation. Respir Res. 2011, 12: 39-CrossRefPubMedPubMedCentral
26.
Hall DJ, Bates ME, Guar L, Cronan M, Korpi N, Bertics PJ: The role of p38 MAPK in rhinovirus-induced monocyte chemoattractant protein-1 production by monocytic-lineage cells. J Immunol. 2005, 174 (12): 8056-8063.CrossRefPubMed
27.
Di Rosa M, Malaguarnera G, De Gregorio C, Drago F, Malaguarnera L: Evaluation of CHI3L-1 and CHIT-1 expression in differentiated and polarized macrophages. Inflammation. 2013, 36 (2): 482-492.CrossRefPubMed
28.
Mygind ND, Iversen K, Kober L, Goetze JP, Nielsen H, Boesgaard S, Bay M, Johansen JS, Nielsen OW, Kirk V, Kastrup J: The inflammatory biomarker YKL-40 at admission is a strong predictor of overall mortality. J Intern Med. 2013, 273 (2): 205-216.CrossRefPubMed
Metadata
Title
CHI3L1polymorphisms associate with asthma in a Taiwanese population
Authors
Yishan Tsai
Yingchin Ko
Mingshyan Huang
Mengchih Lin
Chaochien Wu
Chinchou Wang
Yunxuan Chen
Jianing Li
Yuting Tseng
Tsunai Wang
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Medical Genetics / Issue 1/2014
Electronic ISSN: 1471-2350
DOI
https://doi.org/10.1186/1471-2350-15-86

Other articles of this Issue 1/2014

BMC Medical Genetics 1/2014 Go to the issue

Research article

Novel TBX1loss-of-function mutation causes isolated conotruncal heart defects in Chinese patients without 22q11.2 deletion

Research article

Single nucleotide polymorphisms in TNFAIP3 were associated with the risks of rheumatoid arthritis in northern Chinese Han population

Research article

Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1

Case report

Cryptic FMR1 mosaic deletion in a phenotypically normal mother of a boy with fragile X syndrome: case report

Study protocol

Improving family communication after a new genetic diagnosis: a randomised controlled trial of a genetic counselling intervention

Research article

Autism-epilepsy phenotype with macrocephaly suggests PTEN, but not GLIALCAM, genetic screening