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Open Access 01-12-2011 | Research article

Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review

Authors: Mehlika Toy, Fatih Oguz Önder, Tanja Wörmann, A Mithat Bozdayi, Solko W Schalm, Gerard J Borsboom, Joost van Rosmalen, Jan Hendrik Richardus, Cihan Yurdaydin

Published in: BMC Infectious Diseases | Issue 1/2011

Abstract

Background

To provide a clear picture of the current hepatitis B situation, the authors performed a systematic review to estimate the age- and region-specific prevalence of chronic hepatitis B (CHB) in Turkey.

Methods

A total of 339 studies with original data on the prevalence of hepatitis B surface antigen (HBsAg) in Turkey and published between 1999 and 2009 were identified through a search of electronic databases, by reviewing citations, and by writing to authors. After a critical assessment, the authors included 129 studies, divided into categories: 'age-specific'; 'region-specific'; and 'specific population group'. To account for the differences among the studies, a generalized linear mixed model was used to estimate the overall prevalence across all age groups and regions. For specific population groups, the authors calculated the weighted mean prevalence.

Results

The estimated overall population prevalence was 4.57, 95% confidence interval (CI): 3.58, 5.76, and the estimated total number of CHB cases was about 3.3 million. The outcomes of the age-specific groups varied from 2.84, (95% CI: 2.60, 3.10) for the 0-14-yearolds to 6.36 (95% CI: 5.83, 6.90) in the 25-34-year-old group.

Conclusion

There are large age-group and regional differences in CHB prevalence in Turkey, where CHB remains a serious health problem.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/11/337/prepub

Title: Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review
Authors: Mehlika Toy
Fatih Oguz Önder
Tanja Wörmann
A Mithat Bozdayi
Solko W Schalm
Gerard J Borsboom
Joost van Rosmalen
Jan Hendrik Richardus
Cihan Yurdaydin
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: BMC Infectious Diseases / Issue 1/2011
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/1471-2334-11-337

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Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review

Abstract

Background

Methods

Results

Conclusion

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Abstract

Background

Methods

Results

Conclusion

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