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Published in: BMC Cardiovascular Disorders 1/2014

Open Access 01-12-2014 | Research article

Using the LACE index to predict hospital readmissions in congestive heart failure patients

Authors: Hao Wang, Richard D Robinson, Carlos Johnson, Nestor R Zenarosa, Rani D Jayswal, Joshua Keithley, Kathleen A Delaney

Published in: BMC Cardiovascular Disorders | Issue 1/2014

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Abstract

Background

The LACE index has been used to predict the risk of unplanned readmission within 30 days after hospital discharge in both medical and surgical patients. The aim of this study is to validate the accuracy of using the LACE index in CHF patients.

Methods

This was a retrospective study. The LACE index score was calculated on each patient who was admitted to hospital due to an acute CHF exacerbation. Operational and clinical variables were collected from patients including basic clinical characteristics, length of hospitalization, comorbidities, number of previous ED visits in the past 6 months before the index admission, and the number of post discharge ED revisits at 30, 60, and 90 days. All variables were analyzed by multivariate logistic regression to determine the association between clinical variables and the hospital unplanned readmissions. C-statistic was used to discriminate those patients with high risk of readmissions.

Results

Of the 253 patients included in the study, 24.50% (62/253) experienced unplanned readmission to hospital within 30 days after discharge. The LACE index was slightly higher in patients readmitted versus patients not readmitted (12.17 ± 2.22 versus 11.80 ± 1.92, p = 0.199). Adjusted odds ratios based on logistic regression of all clinical variables showed only the number of previous ED visits (OR 1.79, 95% CI 1.30-2.47, p < 0.001), history of myocardial infarction (OR 2.51, 95% CI 1.02-6.21, p = 0.045), and history of peripheral vascular disease (OR 10.75, 95% CI 1.52-75.73, p = 0.017) increased the risk of unplanned readmission within 30 days of hospital discharge. However, patients with high LACE scores (≥10) had a significantly higher rate of ED revisits (15.04% vs 0%) within 30 days from the index discharge than those with low LACE scores (p = 0.030).

Conclusion

The LACE index may not accurately predict unplanned readmissions within 30 days from hospital discharge in CHF patients. The LACE high risk index may have utility as a screening tool to predict high risk ED revisits after hospital discharge.
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Literature
1.
go back to reference Ben-Chetrit E, Chen-Shuali C, Zimran E, Munter G, Nesher G: A simplified scoring tool for prediction of readmission in elderly patients hospitalized in internal medicine departments. Isr Med Assoc J. 2012, 14: 752-756.PubMed Ben-Chetrit E, Chen-Shuali C, Zimran E, Munter G, Nesher G: A simplified scoring tool for prediction of readmission in elderly patients hospitalized in internal medicine departments. Isr Med Assoc J. 2012, 14: 752-756.PubMed
2.
go back to reference Balla U, Malnick S, Schattner A: Early readmissions to the department of medicine as a screening tool for monitoring quality of care problems. Medicine (Baltimore). 2008, 87: 294-300.CrossRef Balla U, Malnick S, Schattner A: Early readmissions to the department of medicine as a screening tool for monitoring quality of care problems. Medicine (Baltimore). 2008, 87: 294-300.CrossRef
3.
go back to reference Jencks SF, Williams MV, Coleman EA: Rehospitalizations among patients in the Medicare fee-for-service program. N Engl J Med. 2009, 360: 1418-1428.CrossRefPubMed Jencks SF, Williams MV, Coleman EA: Rehospitalizations among patients in the Medicare fee-for-service program. N Engl J Med. 2009, 360: 1418-1428.CrossRefPubMed
4.
go back to reference Stewart S, Vandenbroek AJ, Pearson S, Horowitz JD: Prolonged beneficial effects of a home-based intervention on unplanned readmissions and mortality among patients with congestive heart failure. Arch Intern Med. 1999, 159: 257-261.CrossRefPubMed Stewart S, Vandenbroek AJ, Pearson S, Horowitz JD: Prolonged beneficial effects of a home-based intervention on unplanned readmissions and mortality among patients with congestive heart failure. Arch Intern Med. 1999, 159: 257-261.CrossRefPubMed
5.
go back to reference Stewart S, Marley JE, Horowitz JD: Effects of a multidisciplinary, home-based intervention on unplanned readmissions and survival among patients with chronic congestive heart failure: a randomised controlled study. Lancet. 1999, 354: 1077-1083.CrossRefPubMed Stewart S, Marley JE, Horowitz JD: Effects of a multidisciplinary, home-based intervention on unplanned readmissions and survival among patients with chronic congestive heart failure: a randomised controlled study. Lancet. 1999, 354: 1077-1083.CrossRefPubMed
6.
go back to reference McAlister FA, Youngson E, Bakal JA, Kaul P, Ezekowitz J, van Walraven C: Impact of physician continuity on death or urgent readmission after discharge among patients with heart failure. CMAJ. 2013, 185: E681-E689.CrossRefPubMedPubMedCentral McAlister FA, Youngson E, Bakal JA, Kaul P, Ezekowitz J, van Walraven C: Impact of physician continuity on death or urgent readmission after discharge among patients with heart failure. CMAJ. 2013, 185: E681-E689.CrossRefPubMedPubMedCentral
7.
go back to reference van Walraven C, Wong J, Forster AJ: LACE + index: extension of a validated index to predict early death or urgent readmission after hospital discharge using administrative data. Open Med. 2012, 6: e80-e90.PubMedPubMedCentral van Walraven C, Wong J, Forster AJ: LACE + index: extension of a validated index to predict early death or urgent readmission after hospital discharge using administrative data. Open Med. 2012, 6: e80-e90.PubMedPubMedCentral
8.
go back to reference van Walraven C, Dhalla IA, Bell C, Etchells E, Stiell IG, Zarnke K, Austin PC, Forster AJ: Derivation and validation of an index to predict early death or unplanned readmission after discharge from hospital to the community. CMAJ. 2010, 182: 551-557.CrossRefPubMedPubMedCentral van Walraven C, Dhalla IA, Bell C, Etchells E, Stiell IG, Zarnke K, Austin PC, Forster AJ: Derivation and validation of an index to predict early death or unplanned readmission after discharge from hospital to the community. CMAJ. 2010, 182: 551-557.CrossRefPubMedPubMedCentral
9.
go back to reference Gruneir A, Dhalla IA, van Walraven C, Fischer HD, Camacho X, Rochon PA, Anderson GM: Unplanned readmissions after hospital discharge among patients identified as being at high risk for readmission using a validated predictive algorithm. Open Med. 2011, 5: e104-e111.PubMedPubMedCentral Gruneir A, Dhalla IA, van Walraven C, Fischer HD, Camacho X, Rochon PA, Anderson GM: Unplanned readmissions after hospital discharge among patients identified as being at high risk for readmission using a validated predictive algorithm. Open Med. 2011, 5: e104-e111.PubMedPubMedCentral
10.
go back to reference Cotter PE, Bhalla VK, Wallis SJ, Biram RW: Predicting readmissions: poor performance of the LACE index in an older UK population. Age Ageing. 2012, 41: 784-789.CrossRefPubMed Cotter PE, Bhalla VK, Wallis SJ, Biram RW: Predicting readmissions: poor performance of the LACE index in an older UK population. Age Ageing. 2012, 41: 784-789.CrossRefPubMed
11.
go back to reference Tan SY, Low LL, Yang Y, Lee KH: Applicability of a previously validated readmission predictive index in medical patients in Singapore: a retrospective study. BMC Health Serv Res. 2013, 13: 366-CrossRefPubMedPubMedCentral Tan SY, Low LL, Yang Y, Lee KH: Applicability of a previously validated readmission predictive index in medical patients in Singapore: a retrospective study. BMC Health Serv Res. 2013, 13: 366-CrossRefPubMedPubMedCentral
12.
go back to reference Gwadry-Sridhar FH, Flintoft V, Lee DS, Lee H, Guyatt GH: A systematic review and meta-analysis of studies comparing readmission rates and mortality rates in patients with heart failure. Arch Intern Med. 2004, 164: 2315-2320.CrossRefPubMed Gwadry-Sridhar FH, Flintoft V, Lee DS, Lee H, Guyatt GH: A systematic review and meta-analysis of studies comparing readmission rates and mortality rates in patients with heart failure. Arch Intern Med. 2004, 164: 2315-2320.CrossRefPubMed
13.
go back to reference Pandor A, Gomersall T, Stevens JW, Wang J, Al-Mohammad A, Bakhai A, Cleland JG, Cowie MR, Wong R: Remote monitoring after recent hospital discharge in patients with heart failure: a systematic review and network meta-analysis. Heart. 2013, 99: 1717-1726.CrossRefPubMed Pandor A, Gomersall T, Stevens JW, Wang J, Al-Mohammad A, Bakhai A, Cleland JG, Cowie MR, Wong R: Remote monitoring after recent hospital discharge in patients with heart failure: a systematic review and network meta-analysis. Heart. 2013, 99: 1717-1726.CrossRefPubMed
14.
go back to reference Au AG, McAlister FA, Bakal JA, Ezekowitz J, Kaul P, van Walraven C: Predicting the risk of unplanned readmission or death within 30 days of discharge after a heart failure hospitalization. Am Heart J. 2012, 164: 365-372.CrossRefPubMed Au AG, McAlister FA, Bakal JA, Ezekowitz J, Kaul P, van Walraven C: Predicting the risk of unplanned readmission or death within 30 days of discharge after a heart failure hospitalization. Am Heart J. 2012, 164: 365-372.CrossRefPubMed
15.
go back to reference Islam T, O'Connell B, Lakhan P: Hospital readmission among older adults with congestive heart failure. Aust Health Rev. 2013, 37: 362-368.PubMed Islam T, O'Connell B, Lakhan P: Hospital readmission among older adults with congestive heart failure. Aust Health Rev. 2013, 37: 362-368.PubMed
16.
go back to reference McNaughton CD, Collins SP, Kripalani S, Rothman R, Self WH, Jenkins C, Miller K, Arbogast P, Naftilan A, Dittus RS, Storrow AB: Low numeracy is associated with increased odds of 30-day emergency department or hospital recidivism for patients with acute heart failure. Circ Heart Fail. 2013, 6: 40-46.CrossRefPubMed McNaughton CD, Collins SP, Kripalani S, Rothman R, Self WH, Jenkins C, Miller K, Arbogast P, Naftilan A, Dittus RS, Storrow AB: Low numeracy is associated with increased odds of 30-day emergency department or hospital recidivism for patients with acute heart failure. Circ Heart Fail. 2013, 6: 40-46.CrossRefPubMed
17.
go back to reference Ellery S, Pakrashi T, Paul V, Sack S: Predicting mortality and rehospitalization in heart failure patients with home monitoring–the Home CARE pilot study. Clin Res Cardiol. 2006, 3 (Suppl 3): III29-III35. Ellery S, Pakrashi T, Paul V, Sack S: Predicting mortality and rehospitalization in heart failure patients with home monitoring–the Home CARE pilot study. Clin Res Cardiol. 2006, 3 (Suppl 3): III29-III35.
18.
go back to reference McPhee JT, Barshes NR, Ho KJ, Madenci A, Ozaki CK, Nguyen LL, Belkin M: Predictive factors of 30-day unplanned readmission after lower extremity bypass. J Vasc Surg. 2013, 57: 955-962.CrossRefPubMed McPhee JT, Barshes NR, Ho KJ, Madenci A, Ozaki CK, Nguyen LL, Belkin M: Predictive factors of 30-day unplanned readmission after lower extremity bypass. J Vasc Surg. 2013, 57: 955-962.CrossRefPubMed
19.
go back to reference Ashton CM, Kuykendall DH, Johnson ML, Wray NP, Wu L: The association between the quality of inpatient care and early readmission. Ann Intern Med. 1995, 122: 415-421.CrossRefPubMed Ashton CM, Kuykendall DH, Johnson ML, Wray NP, Wu L: The association between the quality of inpatient care and early readmission. Ann Intern Med. 1995, 122: 415-421.CrossRefPubMed
20.
go back to reference Kossovsky MP, Sarasin FP, Perneger TV, Chopard P, Sigaud P, Gaspoz J: Unplanned readmissions of patients with congestive heart failure: do they reflect in-hospital quality of care or patient characteristics?. Am J Med. 2000, 109: 386-390.CrossRefPubMed Kossovsky MP, Sarasin FP, Perneger TV, Chopard P, Sigaud P, Gaspoz J: Unplanned readmissions of patients with congestive heart failure: do they reflect in-hospital quality of care or patient characteristics?. Am J Med. 2000, 109: 386-390.CrossRefPubMed
21.
go back to reference Braithwaite D, Moore DH, Satariano WA, Kwan ML, Hiatt RA, Kroenke C, Caan BJ: Prognostic impact of comorbidity among long-term breast cancer survivors: results from the LACE study. Cancer Epidemiol Biomarkers Prev. 2012, 21: 1115-1125.CrossRefPubMedPubMedCentral Braithwaite D, Moore DH, Satariano WA, Kwan ML, Hiatt RA, Kroenke C, Caan BJ: Prognostic impact of comorbidity among long-term breast cancer survivors: results from the LACE study. Cancer Epidemiol Biomarkers Prev. 2012, 21: 1115-1125.CrossRefPubMedPubMedCentral
22.
go back to reference Dai YT, Wu SC, Weng R: Unplanned hospital readmission and its predictors in patients with chronic conditions. J Formos Med Assoc. 2002, 101: 779-785.PubMed Dai YT, Wu SC, Weng R: Unplanned hospital readmission and its predictors in patients with chronic conditions. J Formos Med Assoc. 2002, 101: 779-785.PubMed
23.
go back to reference Wong EL, Cheung AW, Leung MC, Yam CH, Chan FW, Wong FY, Yeoh EK: Unplanned readmission rates, length of hospital stay, mortality, and medical costs of ten common medical conditions: a retrospective analysis of Hong Kong hospital data. BMC Health Serv Res. 2011, 11: 149-CrossRefPubMedPubMedCentral Wong EL, Cheung AW, Leung MC, Yam CH, Chan FW, Wong FY, Yeoh EK: Unplanned readmission rates, length of hospital stay, mortality, and medical costs of ten common medical conditions: a retrospective analysis of Hong Kong hospital data. BMC Health Serv Res. 2011, 11: 149-CrossRefPubMedPubMedCentral
24.
go back to reference Clark RM, Growdon WB, Wiechert A, Boruta D, Del CM, Goodman AK, Bradford L, Rauh-Hain A, Schorge JO: Patient, treatment and discharge factors associated with hospital readmission within 30 days after surgical cytoreduction for epithelial ovarian carcinoma. Gynecol Oncol. 2013, 130: 407-410.CrossRefPubMed Clark RM, Growdon WB, Wiechert A, Boruta D, Del CM, Goodman AK, Bradford L, Rauh-Hain A, Schorge JO: Patient, treatment and discharge factors associated with hospital readmission within 30 days after surgical cytoreduction for epithelial ovarian carcinoma. Gynecol Oncol. 2013, 130: 407-410.CrossRefPubMed
25.
go back to reference Gruneir A, Bell CM, Bronskill SE, Schull M, Anderson GM, Rochon PA: Frequency and pattern of emergency department visits by long-term care residents–a population-based study. J Am Geriatr Soc. 2010, 58: 510-517.CrossRefPubMed Gruneir A, Bell CM, Bronskill SE, Schull M, Anderson GM, Rochon PA: Frequency and pattern of emergency department visits by long-term care residents–a population-based study. J Am Geriatr Soc. 2010, 58: 510-517.CrossRefPubMed
26.
go back to reference Hansagi H, Olsson M, Sjoberg S, Tomson Y, Goransson S: Frequent use of the hospital emergency department is indicative of high use of other health care services. Ann Emerg Med. 2001, 37: 561-567.CrossRefPubMed Hansagi H, Olsson M, Sjoberg S, Tomson Y, Goransson S: Frequent use of the hospital emergency department is indicative of high use of other health care services. Ann Emerg Med. 2001, 37: 561-567.CrossRefPubMed
27.
go back to reference Rask KJ, Williams MV, McNagny SE, Parker RM, Baker DW: Ambulatory health care use by patients in a public hospital emergency department. J Gen Intern Med. 1998, 13: 614-620.CrossRefPubMedPubMedCentral Rask KJ, Williams MV, McNagny SE, Parker RM, Baker DW: Ambulatory health care use by patients in a public hospital emergency department. J Gen Intern Med. 1998, 13: 614-620.CrossRefPubMedPubMedCentral
28.
go back to reference Lyratzopoulos G, Havely D, Gemmell I, Cook GA: Factors influencing emergency medical readmission risk in a UK district general hospital: a prospective study. BMC Emerg Med. 2005, 5: 4-CrossRefPubMedPubMedCentral Lyratzopoulos G, Havely D, Gemmell I, Cook GA: Factors influencing emergency medical readmission risk in a UK district general hospital: a prospective study. BMC Emerg Med. 2005, 5: 4-CrossRefPubMedPubMedCentral
29.
go back to reference Suri MF, Qureshi AI: Readmission within 1 month of discharge among patients with acute ischemic stroke: results of the University HealthSystem Consortium Stroke Benchmarking study. J Vasc Interv Neurol. 2013, 6: 47-51.PubMedPubMedCentral Suri MF, Qureshi AI: Readmission within 1 month of discharge among patients with acute ischemic stroke: results of the University HealthSystem Consortium Stroke Benchmarking study. J Vasc Interv Neurol. 2013, 6: 47-51.PubMedPubMedCentral
30.
go back to reference Aranda JM, Johnson JW, Conti JB: Current trends in heart failure readmission rates: analysis of Medicare data. Clin Cardiol. 2009, 32: 47-52.CrossRefPubMed Aranda JM, Johnson JW, Conti JB: Current trends in heart failure readmission rates: analysis of Medicare data. Clin Cardiol. 2009, 32: 47-52.CrossRefPubMed
31.
go back to reference Richter CA, Kalenga JC, Rowe BH, Bresee LC, Tsuyuki RT: Practice patterns and outcomes in patients presenting to the emergency department with acute heart failure. Can J Cardiol. 2009, 25: e173-e178.CrossRefPubMedPubMedCentral Richter CA, Kalenga JC, Rowe BH, Bresee LC, Tsuyuki RT: Practice patterns and outcomes in patients presenting to the emergency department with acute heart failure. Can J Cardiol. 2009, 25: e173-e178.CrossRefPubMedPubMedCentral
32.
go back to reference Dharmarajan K, Hsieh AF, Lin Z, Bueno H, Ross JS, Horwitz LI, Barreto-Filho JA, Kim N, Suter LG, Bernheim SM, Drye EE, Krumholz HM: Hospital readmission performance and patterns of readmission: retrospective cohort study of Medicare admissions. BMJ. 2013, 347: f6571-CrossRefPubMedPubMedCentral Dharmarajan K, Hsieh AF, Lin Z, Bueno H, Ross JS, Horwitz LI, Barreto-Filho JA, Kim N, Suter LG, Bernheim SM, Drye EE, Krumholz HM: Hospital readmission performance and patterns of readmission: retrospective cohort study of Medicare admissions. BMJ. 2013, 347: f6571-CrossRefPubMedPubMedCentral
Metadata
Title
Using the LACE index to predict hospital readmissions in congestive heart failure patients
Authors
Hao Wang
Richard D Robinson
Carlos Johnson
Nestor R Zenarosa
Rani D Jayswal
Joshua Keithley
Kathleen A Delaney
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Cardiovascular Disorders / Issue 1/2014
Electronic ISSN: 1471-2261
DOI
https://doi.org/10.1186/1471-2261-14-97

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