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Open Access 01-12-2014 | Research article

Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population

Authors: Ki-Bum Won, Hyuk-Jae Chang, Jimin Sung, Sanghoon Shin, In-Jeong Cho, Chi-Young Shim, Geu-Ru Hong, Young Jin Kim, Byung-Wook Choi, Namsik Chung

Published in: BMC Cardiovascular Disorders | Issue 1/2014

Abstract

Background

Metabolic syndrome (MetS) is associated with increased risks of diabetes and coronary artery disease (CAD). Despite the controversial inclusion of established diabetes in MetS, the association between MetS and CAD according to diabetes status has not been elucidated in the Asian population.

Methods

We evaluated the association between MetS and CAD using the parameters including any plaque, obstructive plaque, and coronary artery calcium score (CACS) >100 according to diabetes status in 2,869 symptomatic Korean subjects who underwent cardiac computed tomographic angiography.

Results

The prevalence of MetS was significantly higher in the diabetic subjects than in the non-diabetic subjects (69% vs. 34%, P <0.001). The incidence of any plaque (64% vs. 43%, P <0.001), obstructive plaque (26% vs. 13%, P = 0.006), and CACS >100 (23% vs. 12%, P = 0.012) was significantly higher in diabetic subjects than in non-diabetic subjects. Among the MetS components, decreased high-density lipoprotein level was significantly associated with any plaque (odds ratio [OR] 1.35), obstructive plaque (OR 1.55), and CACS >100 (OR 1.57) in the non-diabetic subjects (P <0.01, respectively). However, none of the MetS components were associated with all the parameters in the diabetic subjects. Multivariate regression analysis revealed that MetS and the number of MetS components (MetSN) were independently associated with any plaque (MetS: OR 1.55, P <0.001; MetSN: OR 1.22, P <0.001), obstructive plaque (MetS: OR 1.52, P = 0.003; MetSN: OR 1.25, P <0.001), and CACS >100 (MetS: OR 1.46, P = 0.015; MetSN: OR 1.21, P = 0.004) only in the non-diabetic subjects, respectively.

Conclusions

MetS was independently associated with the presence and severity of CAD only in the non-diabetic subjects among the symptomatic Korean population.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2261/14/105/prepub

Title: Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population
Authors: Ki-Bum Won
Hyuk-Jae Chang
Jimin Sung
Sanghoon Shin
In-Jeong Cho
Chi-Young Shim
Geu-Ru Hong
Young Jin Kim
Byung-Wook Choi
Namsik Chung
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Cardiovascular Disorders / Issue 1/2014
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/1471-2261-14-105

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