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Respiratory Research
Published in: Respiratory Research 1/2008

Open Access 01-12-2008 | Research

A multivariate analysis of serum nutrient levels and lung function

Authors: Tricia M McKeever, Sarah A Lewis, Henriette A Smit, Peter Burney, Patricia A Cassano, John Britton

Published in: Respiratory Research | Issue 1/2008

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Abstract

Background

There is mounting evidence that estimates of intakes of a range of dietary nutrients are related to both lung function level and rate of decline, but far less evidence on the relation between lung function and objective measures of serum levels of individual nutrients. The aim of this study was to conduct a comprehensive examination of the independent associations of a wide range of serum markers of nutritional status with lung function, measured as the one-second forced expiratory volume (FEV1).

Methods

Using data from the Third National Health and Nutrition Examination Survey, a US population-based cross-sectional study, we investigated the relation between 21 serum markers of potentially relevant nutrients and FEV1, with adjustment for potential confounding factors. Systematic approaches were used to guide the analysis.

Results

In a mutually adjusted model, higher serum levels of antioxidant vitamins (vitamin A, beta-cryptoxanthin, vitamin C, vitamin E), selenium, normalized calcium, chloride, and iron were independently associated with higher levels of FEV1. Higher concentrations of potassium and sodium were associated with lower FEV1.

Conclusion

Maintaining higher serum concentrations of dietary antioxidant vitamins and selenium is potentially beneficial to lung health. In addition other novel associations found in this study merit further investigation.
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Metadata
Title
A multivariate analysis of serum nutrient levels and lung function
Authors
Tricia M McKeever
Sarah A Lewis
Henriette A Smit
Peter Burney
Patricia A Cassano
John Britton
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2008
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/1465-9921-9-67

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