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Open Access 01-12-2013 | Short report

Genetic variants in the NOTCH4 gene influence the clinical features of migraine

Authors: Elisa Rubino, Pierpaola Fenoglio, Salvatore Gallone, Flora Govone, Alessandro Vacca, Paola De Martino, Maria Laura Giobbe, Silvia Boschi, Lorenzo Pinessi, Salvatore Gentile, Innocenzo Rainero

Published in: The Journal of Headache and Pain | Issue 1/2013

Abstract

Background

Recent studies suggested an important role for vascular factors in migraine etiopathogenesis. Notch4 belongs to a family of transmembrane receptors that play an important role in vascular development and maintenance. The aim of this study was to test the hypothesis that polymorphisms of the NOTCH4 gene would modify the occurrence and the clinical features of migraine.

Findings

Using a case–control strategy, we genotyped 239 migraine patients and 264 controls for three different non-synonymous polymorphisms (T320A, G835V, R1346P) of the NOTCH4 gene and for the (CTG) n-encoding polyleucine polymorphism in exon 1. Although the analyzed polymorphisms resulted not associated with migraine, the clinical characteristics of our patients were significantly influenced by the different NOTCH4 genotypes. Longer duration of disease and severity of neurovegetative symptoms during headache attacks were associated with the R1346P and G835V polymorphisms, respectively. In female patients, worsening of migraine symptoms at menarche was significantly correlated with T320A polymorphism.

Conclusions

Our study shows that genetic variations within the NOTCH4 gene significantly modify the clinical characteristics of migraine and may have a role in disease pathogenesis.

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Title: Genetic variants in the NOTCH4 gene influence the clinical features of migraine
Authors: Elisa Rubino
Pierpaola Fenoglio
Salvatore Gallone
Flora Govone
Alessandro Vacca
Paola De Martino
Maria Laura Giobbe
Silvia Boschi
Lorenzo Pinessi
Salvatore Gentile
Innocenzo Rainero
Publication date: 01-12-2013
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 1/2013
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/1129-2377-14-28

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Genetic variants in the NOTCH4 gene influence the clinical features of migraine

Abstract

Background

Findings

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Findings

Conclusions

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