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Open Access 01-12-2020 | Computed Tomography | Original article

Feasibility of CT quantification of intratumoural ¹⁶⁶Ho-microspheres

Authors: R. C. Bakker, R. Bastiaannet, S. A. van Nimwegen, A. D. Barten-van Rijbroek, R. J. J. Van Es, A. J. W. P. Rosenberg, H. W. A. M. de Jong, M. G. E. H. Lam, J. F. W. Nijsen

Published in: European Radiology Experimental | Issue 1/2020

Abstract

Background

Microspheres loaded with radioactive ¹⁶⁶Ho (¹⁶⁶Ho-MS) are novel particles for radioembolisation and intratumoural treatment. Because of the limited penetration of β radiation, quantitative imaging of microsphere distribution is crucial for optimal intratumoural treatment. Computed tomography (CT) may provide high-resolution and fast imaging of the distribution of these microspheres, with lower costs and widespread availability in comparison with current standard single-photon emission tomography (SPECT) and magnetic resonance imaging. This phantom study investigated the feasibility of CT quantification of ¹⁶⁶Ho-MS.

Methods

CT quantification was performed on a phantom with various concentrations of HoCl and Ho-MS to investigate the CT sensitivity and calibrate the CT recovery. ¹⁶⁶Ho-MS were injected into ex vivo tissues, in VX-2 cancer-bearing rabbits, and in patients with head-neck cancer, to demonstrate sensitivity and clinical visibility. The amount of Ho-MS was determined by CT scanning, using a density-based threshold method and compared with a validated ¹⁶⁶Ho SPECT quantification method.

Results

In the phantom, a near perfect linearity (least squares R² > 0.99) between HU values and concentration of ¹⁶⁶Ho was found. Ex vivo tissue experiments showed an excellent correlation (r = 0.99, p < 0.01) between the dose calibrator, SPECT, and CT imaging. CT recovery was on average 86.4% ex vivo, 76.0% in rabbits, and 99.1% in humans.

Conclusion

This study showed that CT-based quantification of Ho microspheres is feasible and is a high-resolution alternative to SPECT-based determination of their local distribution.

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Title: Feasibility of CT quantification of intratumoural 166Ho-microspheres
Authors: R. C. Bakker
R. Bastiaannet
S. A. van Nimwegen
A. D. Barten-van Rijbroek
R. J. J. Van Es
A. J. W. P. Rosenberg
H. W. A. M. de Jong
M. G. E. H. Lam
J. F. W. Nijsen
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keywords: Computed Tomography
Computed Tomography
Brachytherapy
Published in: European Radiology Experimental / Issue 1/2020
Electronic ISSN: 2509-9280
DOI: https://doi.org/10.1186/s41747-020-00157-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Feasibility of CT quantification of intratumoural ¹⁶⁶Ho-microspheres

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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