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Radiation Oncology
Published in: Radiation Oncology 1/2018

Open Access 01-12-2018 | Research

Prognostic significance of tumor-infiltrating lymphocytes in patients with operable tongue cancer

Authors: Wan-Yu Chen, Chen-Tu Wu, Chun-Wei Wang, Keng-Hsueh Lan, Hsiang-Kuang Liang, Bing-Shen Huang, Yih-Leong Chang, Sung-Hsin Kuo, Ann-Lii Cheng

Published in: Radiation Oncology | Issue 1/2018

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Abstract

Background

Our aim was to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) in operable tongue cancer patients.

Methods

The presence of CD3+, CD4+, CD8+, and forkhead box protein P3-positive (FOXP3+) TILs in tumor tissues obtained from 93 patients during surgery was examined using immunohistochemistry.

Results

The 3-year overall survival (OS) of patients with a low CD8/FOXP3 ratio was significantly lower than that of patients with a high CD8/FOXP3 ratio (63.8% vs. 87.3%, p = 0.001). Patients with high FOXP3 had a significantly lower 3-year regional recurrence-free survival (RRFS) than did patients with low FOXP3 (49.3% vs. 87.3%, univariate log rank p = 0.000). A low CD4/FOXP3 ratio (68.4% vs. 93.7%, univariate log rank p = 0.002) was significantly unfavorable prognostic factors for 3-year distant metastasis-free survival (DMFS).

Conclusions

In addition to clinicopathological characteristics, TIL markers represent prognosticators for clinical outcomes.
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Metadata
Title
Prognostic significance of tumor-infiltrating lymphocytes in patients with operable tongue cancer
Authors
Wan-Yu Chen
Chen-Tu Wu
Chun-Wei Wang
Keng-Hsueh Lan
Hsiang-Kuang Liang
Bing-Shen Huang
Yih-Leong Chang
Sung-Hsin Kuo
Ann-Lii Cheng
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2018
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-018-1099-6

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