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Clinical and Translational Medicine

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Open Access 01-12-2019 | Ulcerative Colitis | Review

Mesenchymal stem cell–gut microbiota interaction in the repair of inflammatory bowel disease: an enhanced therapeutic effect

Authors: Dickson Kofi Wiredu Ocansey, Li Wang, Jingyan Wang, Yongmin Yan, Hui Qian, Xu Zhang, Wenrong Xu, Fei Mao

Published in: Clinical and Translational Medicine | Issue 1/2019

Abstract

Background

Several investigations affirm that, patients with inflammatory bowel disease (IBD) exhibit dysbiosis characterized by restricted biodiversity and imbalanced bacterial composition intertwined with immune dysregulation. The interaction between stem cells and gut microbiota is a novel and highly promising field that could add up to a better understanding of the gut physiology, as well as therapeutic improvement towards diseases like IBD. Through direct contact or release of products and/or metabolites, gut bacteria regulate gut homeostasis, damage repair, regeneration and differentiation of stem cells. In the same way, mesenchymal stem cells (MSCs) produce similar effects including restoration of gut–microbiome composition.

Body

We reviewed the anti-inflammatory, antimicrobial, pathogenic bacterial clearance, proliferation and tissue remodeling effects of mesenchymal stem cells (MSCs) and fecal microbiota transplantation (FMT) as separate transplants in IBD, and the outcome of the interaction between MSCs and gut microbiota.

Conclusion

The two therapies share several points of connection in therapeutics with enhanced functionalities in their interaction with each other. Focused investigations of MSC–gut bacteria interactions could lead to a novel discovery in therapeutics. We also anticipate an improved clinical remission rate in a combined FMT–MSC transplantation approach in IBD than the current single FMT or MSC approach.

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Title: Mesenchymal stem cell–gut microbiota interaction in the repair of inflammatory bowel disease: an enhanced therapeutic effect
Authors: Dickson Kofi Wiredu Ocansey
Li Wang
Jingyan Wang
Yongmin Yan
Hui Qian
Xu Zhang
Wenrong Xu
Fei Mao
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Keywords: Ulcerative Colitis
Crohn's Disease
Chronic Inflammatory Bowel Disease
Respiratory Microbiota
Published in: Clinical and Translational Medicine / Issue 1/2019
Electronic ISSN: 2001-1326
DOI: https://doi.org/10.1186/s40169-019-0251-8

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Mesenchymal stem cell–gut microbiota interaction in the repair of inflammatory bowel disease: an enhanced therapeutic effect

Abstract

Background

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Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

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Conclusion

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