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Clinical and Translational Medicine
Published in: Clinical and Translational Medicine 1/2019

Open Access 01-12-2019 | Hepatocellular Carcinoma | Review

Epigenetics of hepatocellular carcinoma

Authors: Tan Boon Toh, Jhin Jieh Lim, Edward Kai-Hua Chow

Published in: Clinical and Translational Medicine | Issue 1/2019

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Abstract

In recent years, large scale genomics and genome-wide studies using comprehensive genomic tools have reshaped our understanding of cancer evolution and heterogeneity. Hepatocellular carcinoma, being one of the most deadly cancers in the world has been well established as a disease of the genome that harbours a multitude of genetic and epigenetic aberrations during the process of liver carcinogenesis. As such, in depth understanding of the cancer epigenetics in cancer specimens and biopsy can be useful in clinical settings for molecular subclassification, prognosis, and prediction of therapeutic responses. In this review, we present a concise discussion on recent progress in the field of liver cancer epigenetics and some of the current works that contribute to the progress of liver cancer therapeutics.
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Metadata
Title
Epigenetics of hepatocellular carcinoma
Authors
Tan Boon Toh
Jhin Jieh Lim
Edward Kai-Hua Chow
Publication date
01-12-2019
Publisher
Springer Berlin Heidelberg
Published in
Clinical and Translational Medicine / Issue 1/2019
Electronic ISSN: 2001-1326
DOI
https://doi.org/10.1186/s40169-019-0230-0

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