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Clinical and Translational Allergy
Published in: Clinical and Translational Allergy 1/2019

Open Access 01-12-2019 | Mites | Research

Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort

Authors: Filip Raciborski, Jean Bousqet, Andrzej Namysłowski, Edyta Krzych-Fałta, Aneta Tomaszewska, Barbara Piekarska, Piotr Samel-Kowalik, Artur Z. Białoszewski, Artur Walkiewicz, Agnieszka Lipiec, Oksana Wojas, Krzysztof Samoliński, Anna Szylling, Wojciech Zieliński, Adam Sybilski, Aleksandra Grąbczewska, Bolesław Samoliński

Published in: Clinical and Translational Allergy | Issue 1/2019

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Abstract

Background

Links between multimorbidity of allergic diseases and allergen sensitization are still under debate, especially in adults. This study aimed to establish a relationship between polysensitization and allergic multimorbidity in children and adults and the allergens involved in multimorbidity.

Material and method

A cross-sectional multicentre study enrolled children aged 6–7 and 13–14 years and adults aged 20–44 years from a Polish national cohort. The diagnosis of allergic diseases was made by a physician. Skin prick tests to 13 allergens and serum IgE levels to 4 allergens were tested.

Results

Among the 3856 participants, single disease (asthma, allergic rhinitis or atopic dermatitis) was diagnosed in 27.7% subjects and allergic multimorbidity in 9.3%. Allergic multimorbidity occurred more commonly in children than in adults (p < 0.01). Asthma or atopic dermatitis alone were not associated with polysensitization. Rhinitis and multimorbidity were associated with polysensitization. Allergic multimorbidity occurred in 2.2% of participants with negative skin prick tests, 9.8% of those with one positive prick test (SPT ≥ 3 mm) and 20.6% of polysensitized ones (p < 0.001). There was an increasing risk of multimorbidity depending on the number of positive prick tests for both SPT ≥ 3 mm (OR 9.6–16.5) and SPT ≥ 6 mm (OR 5.9–13.7). A statistically significant relationship was found between allergic multimorbidity and sensitization to cat and mite allergens.

Conclusions

Multimorbidity is associated with polysensitization especially in children compared with adults in Polish population cohort. New insights into single disease patterns were found: bronchial asthma is the strongest risk factor for the development of multimorbidity in comparison with allergic rhinitis and atopic dermatitis.
Appendix
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Metadata
Title
Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort
Authors
Filip Raciborski
Jean Bousqet
Andrzej Namysłowski
Edyta Krzych-Fałta
Aneta Tomaszewska
Barbara Piekarska
Piotr Samel-Kowalik
Artur Z. Białoszewski
Artur Walkiewicz
Agnieszka Lipiec
Oksana Wojas
Krzysztof Samoliński
Anna Szylling
Wojciech Zieliński
Adam Sybilski
Aleksandra Grąbczewska
Bolesław Samoliński
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Clinical and Translational Allergy / Issue 1/2019
Electronic ISSN: 2045-7022
DOI
https://doi.org/10.1186/s13601-019-0246-y

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