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Allergy, Asthma & Clinical Immunology
Published in: Allergy, Asthma & Clinical Immunology 1/2020

01-12-2020 | Allergic Rhinitis | Review

Quercetin with the potential effect on allergic diseases

Authors: Morteza Jafarinia, Mahnaz Sadat Hosseini, Neda kasiri, Niloofar Fazel, Farshid Fathi, Mazdak Ganjalikhani Hakemi, Nahid Eskandari

Published in: Allergy, Asthma & Clinical Immunology | Issue 1/2020

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Abstract

Quercetin is a naturally occurring polyphenol flavonoid which is rich in antioxidants. It has anti-allergic functions that are known for inhibiting histamine production and pro-inflammatory mediators. Quercetin can regulate the Th1/Th2 stability, and decrease the antigen-specific IgE antibody releasing by B cells. Quercetin has a main role in anti-inflammatory and immunomodulatory function which makes it proper for the management of different diseases. Allergic diseases are a big concern and have high health care costs. In addition, the use of current therapies such as ß2-agonists and corticosteroids has been limited for long term use due to their numerous side effects. Since the effect of quercetin on allergic diseases has been widely studied, in the current article, we review the effect of quercetin on allergic diseases, such as allergic asthma, allergic rhinitis (AR), and atopic dermatitis (AD).
Literature
1.
Jafarinia M, Jafarinia M. A review of medicinal properties of some Asteraceae family plants on immune system. Rep Health Care. 2019;5(2):1–7.
2.
3.
Wiczkowski W, et al. Quercetin from shallots (Allium cepa L. var. aggregatum) is more bioavailable than its glucosides. J Nutr. 2008;138(5):885–8.PubMedCrossRef
4.
Williamson G, Manach C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr. 2005;81(1):243S–55S.PubMedCrossRef
5.
Bhagwat S, Haytowitz DB, Holden JM. USDA database for the flavonoid content of selected foods, Release 3.1. US Department of Agriculture: Beltsville, MD, USA, 2014.
6.
Harwood M, et al. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol. 2007;45(11):2179–205.PubMedCrossRef
7.
Gupta A, et al. Quercetin: a wonder bioflavonoid with therapeutic potential in disease management. Asian Pac J Trop Dis. 2016;6(3):248–52.CrossRef
8.
Lakhanpal P, Rai DK. Quercetin: a versatile flavonoid. Internet J Med Update. 2007;2(2):22–37.
9.
10.
Ghosh B. Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-α production in murine macrophages. Int J Immunopharmacol. 1999;21(7):435–43.PubMedCrossRef
11.
Geraets L, et al. Dietary flavones and flavonoles are inhibitors of poly (ADP-ribose) polymerase-1 in pulmonary epithelial cells. J Nutr. 2007;137(10):2190–5.PubMedCrossRef
12.
Bureau G, Longpré F, Martinoli MG. Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation. J Neurosci Res. 2008;86(2):403–10.PubMedCrossRef
13.
Lee KM, et al. Protective effect of quercetin against arsenite-induced COX-2 expression by targeting PI3K in rat liver epithelial cells. J Agric Food Chem. 2010;58(9):5815–20.PubMedCrossRef
14.
Kempuraj D, et al. Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. Br J Pharmacol. 2005;145(7):934–44.PubMedPubMedCentralCrossRef
15.
Formica J, Regelson W. Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol. 1995;33(12):1061–80.PubMedCrossRef
16.
Joskova M, Franova S, Sadlonova V. Acute bronchodilator effect of quercetin in experimental allergic asthma. Bratisl Lek Listy. 2011;112(1):9–12.PubMed
17.
Rogerio AP, et al. Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice. Pharmacol Res. 2010;61(4):288–97.PubMedCrossRef
18.
Oja A. The inhibitory effects of flavonoids on chemokine function in allergic asthma and food allergy. 2014.
19.
Fortunato LR, et al. Quercetin: a flavonoid with the potential to treat asthma. Braz J Pharm Sci. 2012;48(4):589–99.CrossRef
20.
Park H-J, et al. Quercetin regulates Th1/Th2 balance in a murine model of asthma. Int Immunopharmacol. 2009;9(3):261–7.PubMedCrossRef
21.
Jung CH, et al. Anti-asthmatic action of quercetin and rutin in conscious guinea-pigs challenged with aerosolized ovalbumin. Arch Pharmacal Res. 2007;30(12):1599.CrossRef
22.
Romagnani S. Immunologic influences on allergy and the TH1/TH2 balance. J Allergy Clin Immunol. 2004;113(3):395–400.PubMedCrossRef
23.
Chabra R, Gupta M. Allergic and environmental induced asthma. In: StatPearls. StatPearls Publishing; 2019.
24.
Capasso R, et al. Inhibitory effect of quercetin on rat trachea contractility in vitro. J Pharm Pharmacol. 2009;61(1):115–9.PubMedCrossRef
25.
Chang JH, et al. Dietary polyphenols affect MUC5AC expression and ciliary movement in respiratory cells and nasal mucosa. Am J Rhinol Allergy. 2010;24(2):e59–62.PubMedCrossRef
26.
Li N, et al. The effect of quercetin on human neutrophil elastase-induced mucin5AC expression in human airway epithelial cells. Int Immunopharmacol. 2012;14(2):195–201.PubMedCrossRef
27.
Moon H, et al. Quercetin inhalation inhibits the asthmatic responses by exposure to aerosolized-ovalbumin in conscious guinea-pigs. Arch Pharmacal Res. 2008;31(6):771.CrossRef
28.
Zhu JX, et al. Quercetin, kaempferol and isorhamnetin in Elaeagnus pungens Thunb. leaf: pharmacological activities and quantitative determination studies. Chem Biodivers. 2018;15(8):e1800129.PubMedCrossRef
29.
Rogerio A, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007;56(10):402–8.PubMedCrossRef
30.
Baowen Q, et al. A further investigation concerning correlation between anti-fibrotic effect of liposomal quercetin and inflammatory cytokines in pulmonary fibrosis. Eur J Pharmacol. 2010;642(1–3):134–9.PubMedCrossRef
31.
Sozmen SC, et al. Effects of quercetin treatment on epithelium-derived cytokines and epithelial cell apoptosis in allergic airway inflammation mice model. Iran J Allergy Asthma Immunol. 2016;15(6):487–97.
32.
33.
Cruz E, et al. Kalanchoe pinnata inhibits mast cell activation and prevents allergic airway disease. Phytomedicine. 2012;19(2):115–21.PubMedCrossRef
34.
35.
Oliveira TT, et al. Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma. DARU J Pharm Sci. 2015;23(1):18.CrossRef
36.
Townsend EA, Emala CW Sr. Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4. Am J Physiol Lung Cell Mol Physiol. 2013;305(5):L396–403.PubMedPubMedCentralCrossRef
37.
38.
Irie S, et al. Suppressive activity of quercetin on periostin functions in vitro. In Vivo. 2016;30(1):17–25.PubMed
39.
Otsuka H, et al. Histochemical and functional characteristics of metachromatic cells in the nasal epithelium in allergic rhinitis: studies of nasal scrapings and their dispersed cells. J Allergy Clin Immunol. 1995;96(4):528–36.PubMedCrossRef
40.
Thornhill SM, Kelly A-M. Natural treatment of perennial allergic rhinitis. Altern Med Rev. 2000;5(5):448–54.PubMed
41.
Ebihara N, et al. Suppressive effect of quercetin on nitric oxide production from nasal epithelial cells in vitro. Evid Based Complement Alternat Med. 2018;2018:6097625.PubMedPubMedCentralCrossRef
42.
Kulka M. The potential of natural products as effective treatments for allergic inflammation: implications for allergic rhinitis. Curr Top Med Chem. 2009;9(17):1611–24.PubMedCrossRef
43.
Hu G, et al. The Chinese herbal formulation biminne in management of perennial allergic rhinitis: a randomized, double-blind, placebo-controlled, 12-week clinical trial. Ann Allergy Asthma Immunol. 2002;88(5):478–87.PubMedCrossRef
44.
45.
Sagit M, et al. Effectiveness of quercetin in an experimental rat model of allergic rhinitis. Eur Arch Otorhinolaryngol. 2017;274(8):3087–95.PubMedCrossRef
46.
Ito W, et al. Thioredoxin in allergic inflammation. Int Arch Allergy Immunol. 2011;155(Suppl. 1):142–6.PubMedCrossRef
47.
Edo Y, Otaki A, Asano K. Quercetin enhances the thioredoxin production of nasal epithelial cells in vitro and in vivo. Medicines. 2018;5(4):124.PubMedCentralCrossRef
48.
Choopani R, et al. Treatment of atopic dermatitis from the perspective of traditional Persian medicine: presentation of a novel therapeutic approach. J Evid Based Complement Altern Med. 2017;22(1):5–11.CrossRef
49.
Karuppagounder V, et al. Molecular targets of quercetin with anti-inflammatory properties in atopic dermatitis. Drug Discov Today. 2016;21(4):632–9.PubMedCrossRef
50.
Park EJ, et al. Effect of topical application of quercetin-3-O-(2″-gallate)-α-l-rhamnopyranoside on atopic dermatitis in NC/Nga mice. J Dermatol Sci. 2015;77(3):166–72.PubMedCrossRef
51.
Matsushima M, et al. Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells. Inflamm Res. 2009;58(10):705–15.PubMedCrossRef
52.
Manca ML, et al. Improvement of quercetin protective effect against oxidative stress skin damages by incorporation in nanovesicles. Colloids Surf B. 2014;123:566–74.CrossRef
53.
Jung MK, et al. Tannic acid and quercetin display a therapeutic effect in atopic dermatitis via suppression of angiogenesis and TARC expression in Nc/Nga mice. J Investig Dermatol. 2010;130(5):1459–63.PubMedCrossRef
54.
Caddeo C, et al. Topical anti-inflammatory potential of quercetin in lipid-based nanosystems: in vivo and in vitro evaluation. Pharm Res. 2014;31(4):959–68.CrossRefPubMed
55.
Karuppagounder V, et al. Modulation of HMGB 1 translocation and RAGE/NF κB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice. Exp Dermatol. 2015;24(6):418–23.PubMedCrossRef
56.
Castangia I, et al. Fabrication of quercetin and curcumin bionanovesicles for the prevention and rapid regeneration of full-thickness skin defects on mice. Acta Biomater. 2014;10(3):1292–300.PubMedCrossRef
Metadata
Title
Quercetin with the potential effect on allergic diseases
Authors
Morteza Jafarinia
Mahnaz Sadat Hosseini
Neda kasiri
Niloofar Fazel
Farshid Fathi
Mazdak Ganjalikhani Hakemi
Nahid Eskandari
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Allergy, Asthma & Clinical Immunology / Issue 1/2020
Electronic ISSN: 1710-1492
DOI
https://doi.org/10.1186/s13223-020-00434-0

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