Skip to main content
Top
Published in: Italian Journal of Pediatrics 1/2016

Open Access 01-12-2016 | Review

Novelty in hypertension in children and adolescents: focus on hypertension during the first year of life, use and interpretation of ambulatory blood pressure monitoring, role of physical activity in prevention and treatment, simple carbohydrates and uric acid as risk factors

Authors: Mirella Strambi, Marco Giussani, Maria Amalia Ambruzzi, Paolo Brambilla, Ciro Corrado, Ugo Giordano, Claudio Maffeis, Silvio Maringhin, Maria Chiara Matteucci, Ettore Menghetti, Patrizia Salice, Federico Schena, Pietro Strisciuglio, Giuliana Valerio, Francesca Viazzi, Raffaele Virdis, Simonetta Genovesi

Published in: Italian Journal of Pediatrics | Issue 1/2016

Login to get access

Abstract

The present article intends to provide an update of the article “Focus on prevention, diagnosis and treatment of hypertension in children and adolescents” published in 2013 (Spagnolo et al., Ital J Pediatr 39:20, 2013) in this journal. This revision is justified by the fact that during the last years there have been several new scientific contributions to the problem of hypertension in pediatric age and during adolescence. Nevertheless, for what regards some aspects of the previous article, the newly acquired information did not require substantial changes to what was already published, both from a cultural and from a clinical point of view. We felt, however, the necessity to rewrite and/or to extend other parts in the light of the most recent scientific publications. More specifically, we updated and extended the chapters on the diagnosis and management of hypertension in newborns and unweaned babies, on the use and interpretation of ambulatory blood pressure monitoring, and on the usefulness of and indications for physical activity. Furthermore, we added an entirely new section on the role that simple carbohydrates (fructose in particular) and uric acid may play in the pathogenesis of hypertension in pediatric age.
Literature
1.
go back to reference Task Force on Blood Pressure Control in Children. Report of the Second Blood Pressure Control in Children −1987. Pediatrics. 1987;79:1–25. Task Force on Blood Pressure Control in Children. Report of the Second Blood Pressure Control in Children −1987. Pediatrics. 1987;79:1–25.
2.
go back to reference Kent AL, Kecskes Z, Shadbolt B, Falk MC. Blood pressure in the first year of life in healthy infants born at term. Pediatr Nephrol. 2007;22:1743–9.PubMedCrossRef Kent AL, Kecskes Z, Shadbolt B, Falk MC. Blood pressure in the first year of life in healthy infants born at term. Pediatr Nephrol. 2007;22:1743–9.PubMedCrossRef
3.
go back to reference Cantinotti M, Giordano R, Scalese M, Molinaro S, Murzi B, Assanta N, et al. Strengths and limitations of current pediatric blood pressure nomograms: a global overview with a special emphasis on regional differences in neonates and infants. Hypertens Res. 2015;38:577–87. Cantinotti M, Giordano R, Scalese M, Molinaro S, Murzi B, Assanta N, et al. Strengths and limitations of current pediatric blood pressure nomograms: a global overview with a special emphasis on regional differences in neonates and infants. Hypertens Res. 2015;38:577–87.
4.
go back to reference Zubrow AB, Hulman S, Kushner H, Falkner B. Determinants of blood pressure in infants admitted to neonatal intensive care units: a prospective multicenter study. J Perinatol. 1995;15:470–9.PubMed Zubrow AB, Hulman S, Kushner H, Falkner B. Determinants of blood pressure in infants admitted to neonatal intensive care units: a prospective multicenter study. J Perinatol. 1995;15:470–9.PubMed
5.
go back to reference Kent AL, Meskell S, Falk MC, Shadbolt B. Normative blood pressure data in nonventilated premature neonates from 28–36 weeks gestation. Pediatr Nephrol. 2009;24:141–6.PubMedCrossRef Kent AL, Meskell S, Falk MC, Shadbolt B. Normative blood pressure data in nonventilated premature neonates from 28–36 weeks gestation. Pediatr Nephrol. 2009;24:141–6.PubMedCrossRef
6.
7.
go back to reference Pejovic B, Peco-Antic A, Marinkovic-Eric J. Blood pressure in noncritically ill preterm and full-term neonates. Pediatr Nephrol. 2007;22:249–57.PubMedCrossRef Pejovic B, Peco-Antic A, Marinkovic-Eric J. Blood pressure in noncritically ill preterm and full-term neonates. Pediatr Nephrol. 2007;22:249–57.PubMedCrossRef
8.
go back to reference Lurbe E, Garcia-Vicent C, Torro I, Fayos JL, Aguilar F, de Llano JM, et al. First-year blood pressure increase steepest in low birthweight newborns. J Hypertens. 2007;25:81–6.PubMedCrossRef Lurbe E, Garcia-Vicent C, Torro I, Fayos JL, Aguilar F, de Llano JM, et al. First-year blood pressure increase steepest in low birthweight newborns. J Hypertens. 2007;25:81–6.PubMedCrossRef
9.
go back to reference Sadoh WE, Ibhanesehbor SE, Monguno AM, Gubler DJ. Predictors of newborn systolic blood pressure. West African J Med. 2010;29:86–90. Sadoh WE, Ibhanesehbor SE, Monguno AM, Gubler DJ. Predictors of newborn systolic blood pressure. West African J Med. 2010;29:86–90.
10.
go back to reference Dionne JM, Abitbol CL, Flynn JT. Hypertension in infancy: diagnosis, management and outcome. Pediatr Nephrol. 2012;27:159–60.CrossRef Dionne JM, Abitbol CL, Flynn JT. Hypertension in infancy: diagnosis, management and outcome. Pediatr Nephrol. 2012;27:159–60.CrossRef
11.
go back to reference Dannevig I, Dale H, Liestol K, Lindemann R. Blood pressure in the neonate: Three non-invasive oscillometric pressure monitors compared with invasively measure blood pressure. Acta Paediatr. 2005;94:191–6.PubMedCrossRef Dannevig I, Dale H, Liestol K, Lindemann R. Blood pressure in the neonate: Three non-invasive oscillometric pressure monitors compared with invasively measure blood pressure. Acta Paediatr. 2005;94:191–6.PubMedCrossRef
12.
go back to reference Devinck A, Keukelier H, De Savoye I, Desmet L, Smets K. Neonatal blood pressure monitoring: visual assessment is un unreliable method for selecting cuff sizes. Acta Paediatr. 2013;102:961–4.PubMedCrossRef Devinck A, Keukelier H, De Savoye I, Desmet L, Smets K. Neonatal blood pressure monitoring: visual assessment is un unreliable method for selecting cuff sizes. Acta Paediatr. 2013;102:961–4.PubMedCrossRef
13.
go back to reference Neal WA, Reynolds JW, Jarvis CW, Williams HJ. Umbilical artery catheterization: demonstration of arterial thrombosis by aortography. Pediatrics. 1972;50:6–13.PubMed Neal WA, Reynolds JW, Jarvis CW, Williams HJ. Umbilical artery catheterization: demonstration of arterial thrombosis by aortography. Pediatrics. 1972;50:6–13.PubMed
14.
go back to reference Seibert JJ, Taylor BJ, Williamson SL, Williams BJ, Szabo JS, Corbitt SL. Sonographic detection of neonatal umbilical artery thrombosis: clinical correlation. Am J Roentgenol. 1987;148:965–8.CrossRef Seibert JJ, Taylor BJ, Williamson SL, Williams BJ, Szabo JS, Corbitt SL. Sonographic detection of neonatal umbilical artery thrombosis: clinical correlation. Am J Roentgenol. 1987;148:965–8.CrossRef
15.
go back to reference Ford KT, Teplick SK, Clark RE. Renal artery embolism causing neonatal hypertension. Radiology. 1974;113:169–70.PubMedCrossRef Ford KT, Teplick SK, Clark RE. Renal artery embolism causing neonatal hypertension. Radiology. 1974;113:169–70.PubMedCrossRef
16.
go back to reference Bauer SB, Feldman SM, Gellis SS, Retik AB. Neonatal hypertension: a complication of umbilical-artery catheterization. N Engl J Med. 1975;293:1032–3.PubMedCrossRef Bauer SB, Feldman SM, Gellis SS, Retik AB. Neonatal hypertension: a complication of umbilical-artery catheterization. N Engl J Med. 1975;293:1032–3.PubMedCrossRef
17.
go back to reference Plumer LB, Kaplan GW, Mendoza SA. Hypertension in infants: a complication of umbilical arterial catheterization. J Pediatr. 1976;89:802–5.PubMedCrossRef Plumer LB, Kaplan GW, Mendoza SA. Hypertension in infants: a complication of umbilical arterial catheterization. J Pediatr. 1976;89:802–5.PubMedCrossRef
18.
go back to reference Seliem WA, Falk MC, Shadbolt B, Kent AL. Antenatal and postnatal risk factors for neonatal hypertension and infant follow-up. Pediatr Nephrol. 2007;22:2081–7.PubMedCrossRef Seliem WA, Falk MC, Shadbolt B, Kent AL. Antenatal and postnatal risk factors for neonatal hypertension and infant follow-up. Pediatr Nephrol. 2007;22:2081–7.PubMedCrossRef
19.
go back to reference Abman SH, Warady BA, Lum GM, Koops BL. Systemic hypertension in infants with bronchopulmonary dysplasia. J Pediatr. 1984;104:929–31.CrossRef Abman SH, Warady BA, Lum GM, Koops BL. Systemic hypertension in infants with bronchopulmonary dysplasia. J Pediatr. 1984;104:929–31.CrossRef
20.
go back to reference Sahu R, Pannu H, Yu R, Shete S, Bricker JT, Gupta-Malhotra M. Systemic Hypertension Requiring Treatment in the Neonatal Intensive Care Unit. J Pediatr. 2013;163:84–8.PubMedPubMedCentralCrossRef Sahu R, Pannu H, Yu R, Shete S, Bricker JT, Gupta-Malhotra M. Systemic Hypertension Requiring Treatment in the Neonatal Intensive Care Unit. J Pediatr. 2013;163:84–8.PubMedPubMedCentralCrossRef
21.
go back to reference Alagappan A, Malloy MH. Systemic hypertension in very low-birth weight infants with bronchopulmonary dysplasia: Incidence and risk factors. Am J Perinatol. 1998;15:3–8.PubMedCrossRef Alagappan A, Malloy MH. Systemic hypertension in very low-birth weight infants with bronchopulmonary dysplasia: Incidence and risk factors. Am J Perinatol. 1998;15:3–8.PubMedCrossRef
22.
go back to reference Abman SH. Monitoring cardiovascular function in infants with chronic lung disease of prematurity. Arch Dis Child Fetal Neonatal. 2002;87:F15–18.CrossRef Abman SH. Monitoring cardiovascular function in infants with chronic lung disease of prematurity. Arch Dis Child Fetal Neonatal. 2002;87:F15–18.CrossRef
23.
go back to reference Singh HP, Hurley RM, Myers TF. Neonatal hypertension. Incidence and risk factors. Am J Hypertens. 1992;5:51–5.PubMed Singh HP, Hurley RM, Myers TF. Neonatal hypertension. Incidence and risk factors. Am J Hypertens. 1992;5:51–5.PubMed
24.
go back to reference Farmakis SG, Khanna G. Extracardiac applications of MR blood pool contrast agent in children. Pediatr Radiol. 2014;44:1598–609.PubMedCrossRef Farmakis SG, Khanna G. Extracardiac applications of MR blood pool contrast agent in children. Pediatr Radiol. 2014;44:1598–609.PubMedCrossRef
25.
go back to reference Favilli S, Capuzzo L. Pollini I Usefulness of Doppler ultrasound in the diagnosis of renal artery stenosis in hypertensive children. Two case reports and review of the literature. Ital Heart J Suppl. 2004;5:492–6.PubMed Favilli S, Capuzzo L. Pollini I Usefulness of Doppler ultrasound in the diagnosis of renal artery stenosis in hypertensive children. Two case reports and review of the literature. Ital Heart J Suppl. 2004;5:492–6.PubMed
26.
go back to reference Lanzarini VV, Furusawa EA, Sadeck L, Leone CR, Vaz FA, Koch VH. Neonatal arterial hypertension in nephrourological malformations in a tertiary care Hospital. J Hum Hypertens. 2006;20:679–83.PubMedCrossRef Lanzarini VV, Furusawa EA, Sadeck L, Leone CR, Vaz FA, Koch VH. Neonatal arterial hypertension in nephrourological malformations in a tertiary care Hospital. J Hum Hypertens. 2006;20:679–83.PubMedCrossRef
27.
go back to reference Lindle KA, Dinh K, Moffet BS, Kyle WB, Montgomery NM, Denfield SD, et al. Angiotensin-converting enzyme inhibitor nephrotoxicity in neonates with cardiac disease. Pediatr Cardiol. 2014;35:499–506.PubMedCrossRef Lindle KA, Dinh K, Moffet BS, Kyle WB, Montgomery NM, Denfield SD, et al. Angiotensin-converting enzyme inhibitor nephrotoxicity in neonates with cardiac disease. Pediatr Cardiol. 2014;35:499–506.PubMedCrossRef
28.
go back to reference Tack ED, Perlman JM. Renal failure in sick hypertensive premature infants receiving captopril therapy. J Pediatr. 1988;112:805–10.PubMedCrossRef Tack ED, Perlman JM. Renal failure in sick hypertensive premature infants receiving captopril therapy. J Pediatr. 1988;112:805–10.PubMedCrossRef
29.
go back to reference Filippi L, Cavallaro G, Bagnoli P, Dal Monte M, Fiorini P, Donzelli G, et al. Oral propranolol for retinopathy of prematurity: risks, safety concerns, and perspectives. J Pediatr. 2013;163(6):1570–7.PubMedCrossRef Filippi L, Cavallaro G, Bagnoli P, Dal Monte M, Fiorini P, Donzelli G, et al. Oral propranolol for retinopathy of prematurity: risks, safety concerns, and perspectives. J Pediatr. 2013;163(6):1570–7.PubMedCrossRef
30.
go back to reference Blowey DL, Duda PJ, Stokes P, Hall M. Incidence and treatment of hypertension in the neonatal intensive care unit. J Am Soc Hypertens. 2011;6:478–83.CrossRef Blowey DL, Duda PJ, Stokes P, Hall M. Incidence and treatment of hypertension in the neonatal intensive care unit. J Am Soc Hypertens. 2011;6:478–83.CrossRef
31.
go back to reference Lorell BH. Transition from hypertrophy to failure. Circulation. 1997;96:3824–7.PubMed Lorell BH. Transition from hypertrophy to failure. Circulation. 1997;96:3824–7.PubMed
32.
go back to reference Samuelsson O, Wilhelmsen L, Elmfeldt D, Pennert K, Wedel H, Wickstrand J, et al. Predictors of cardiovascular morbidity in treated hypertension: results from the primary preventive trial in Goteborg, Sweden. J Hypertens. 1985;3:167–76.PubMedCrossRef Samuelsson O, Wilhelmsen L, Elmfeldt D, Pennert K, Wedel H, Wickstrand J, et al. Predictors of cardiovascular morbidity in treated hypertension: results from the primary preventive trial in Goteborg, Sweden. J Hypertens. 1985;3:167–76.PubMedCrossRef
33.
go back to reference Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990;322:1561–6.PubMedCrossRef Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990;322:1561–6.PubMedCrossRef
34.
go back to reference Pieruzzi F, Antolini L, Salerno FR, Giussani M, Brambilla P, Galbiati S, et al. The role of blood pressure, body weight and fat distribution on left ventricular mass, diastolic function and cardiac geometry in children. J Hypertens. 2015;33:1182–92.PubMedCrossRef Pieruzzi F, Antolini L, Salerno FR, Giussani M, Brambilla P, Galbiati S, et al. The role of blood pressure, body weight and fat distribution on left ventricular mass, diastolic function and cardiac geometry in children. J Hypertens. 2015;33:1182–92.PubMedCrossRef
35.
go back to reference Kupferman JC, Paterno K, Mahgerefteh J, Pagala M, Golden M, Lytrivi ID, et al. Improvement of left ventricular mass with antihypertensive therapy in children with hypertension. Pediatr Nephrol. 2010;25:1513–8.PubMedCrossRef Kupferman JC, Paterno K, Mahgerefteh J, Pagala M, Golden M, Lytrivi ID, et al. Improvement of left ventricular mass with antihypertensive therapy in children with hypertension. Pediatr Nephrol. 2010;25:1513–8.PubMedCrossRef
36.
go back to reference Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57:450–8.PubMedCrossRef Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57:450–8.PubMedCrossRef
37.
go back to reference Joyce JJ, Dickson PI, Qi N, Noble JE, Raj JU, Baylen BJ. Normal Right and Left Ventricular Mass Development During Early Infancy. Am J Cardiol. 2004;93:797–801.PubMedCrossRef Joyce JJ, Dickson PI, Qi N, Noble JE, Raj JU, Baylen BJ. Normal Right and Left Ventricular Mass Development During Early Infancy. Am J Cardiol. 2004;93:797–801.PubMedCrossRef
38.
go back to reference Peterson AL, Frommelt PC, Mussatto K. Presentation and Echocardiographic Markers of Neonatal Hypertensive Cardiomyopathy. Pediatrics. 2006;118:e782–5.PubMedCrossRef Peterson AL, Frommelt PC, Mussatto K. Presentation and Echocardiographic Markers of Neonatal Hypertensive Cardiomyopathy. Pediatrics. 2006;118:e782–5.PubMedCrossRef
39.
go back to reference Salice P, Mannarino S, Fesslova V. Modification of LV mass in hypertensive newborns and infants. G Ital Cardiol. 2001;2(Suppl4):17S. Salice P, Mannarino S, Fesslova V. Modification of LV mass in hypertensive newborns and infants. G Ital Cardiol. 2001;2(Suppl4):17S.
40.
go back to reference Levent E, Goksen D, Ozyurek AR, et al. Stiffness of the abdominal aorta in obese children. J Pediatr Endocrinol Metab. 2002;15:405–9.PubMedCrossRef Levent E, Goksen D, Ozyurek AR, et al. Stiffness of the abdominal aorta in obese children. J Pediatr Endocrinol Metab. 2002;15:405–9.PubMedCrossRef
41.
go back to reference Iannuzzi A, Licenziati MR, Acampora C, et al. Preclinical changes in the mechanical properties of abdominal aorta in obese children. Metabolism. 2004;53:1243–6.PubMedCrossRef Iannuzzi A, Licenziati MR, Acampora C, et al. Preclinical changes in the mechanical properties of abdominal aorta in obese children. Metabolism. 2004;53:1243–6.PubMedCrossRef
42.
go back to reference Koudsi A, Oldroyd J, McElduff P, Banerjee M, Vyas A, Cruickshank JK. Maternal and neonatal influences on, and reproducibility of neonatal aortic pulse wave velocity. Hypertension. 2007;49:225–31.PubMedCrossRef Koudsi A, Oldroyd J, McElduff P, Banerjee M, Vyas A, Cruickshank JK. Maternal and neonatal influences on, and reproducibility of neonatal aortic pulse wave velocity. Hypertension. 2007;49:225–31.PubMedCrossRef
43.
go back to reference Cheung Y-F. Arterial stiffness in the young:assessment, determinants, and implications. Korean. Circ J. 2010;40:153–62. Cheung Y-F. Arterial stiffness in the young:assessment, determinants, and implications. Korean. Circ J. 2010;40:153–62.
44.
go back to reference Stergiotou I, Crispi F, Valenzuela-Alcaraz B, Cruz-Lemini M, Bijnens B, Gratacos E. Aortic and carotid intima-media thickness in term small-for-gestational-age newborns and relationship with prenatal signs of severity Ultrasound. Obstet Gynecol. 2014;43(6):625–31. Stergiotou I, Crispi F, Valenzuela-Alcaraz B, Cruz-Lemini M, Bijnens B, Gratacos E. Aortic and carotid intima-media thickness in term small-for-gestational-age newborns and relationship with prenatal signs of severity Ultrasound. Obstet Gynecol. 2014;43(6):625–31.
45.
go back to reference Ingelfinger JR, Nuyt AM. Impact of Fetal Programming, Birth Weight, and Feeding on Later Hypertension. J Clin Hypertens. 2012;14:365–71.CrossRef Ingelfinger JR, Nuyt AM. Impact of Fetal Programming, Birth Weight, and Feeding on Later Hypertension. J Clin Hypertens. 2012;14:365–71.CrossRef
46.
go back to reference Ingelfinger JR, Woods LL. Perinatal programming, renal development, and adult renal function. Am J Hypertens. 2002;15:46S–9S.PubMedCrossRef Ingelfinger JR, Woods LL. Perinatal programming, renal development, and adult renal function. Am J Hypertens. 2002;15:46S–9S.PubMedCrossRef
47.
go back to reference Barker DJ, Gelow J, Thornburg K, Osmond C, Kajantie E, Eriksson JG. The early origins of chronic heart failure: impaired placental growth and initiation of insulin resistance in childhood. Eur J Heart Fail. 2010;12:819–25.PubMedCrossRef Barker DJ, Gelow J, Thornburg K, Osmond C, Kajantie E, Eriksson JG. The early origins of chronic heart failure: impaired placental growth and initiation of insulin resistance in childhood. Eur J Heart Fail. 2010;12:819–25.PubMedCrossRef
48.
go back to reference Genovesi S, Brambilla P, Giussani M, Galbiati S, Mastriani S, Pieruzzi F, et al. L. Insulin resistance, prehypertension, hypertension and blood pressure values in paediatric age. J Hypertens. 2012;30:327–35.PubMedCrossRef Genovesi S, Brambilla P, Giussani M, Galbiati S, Mastriani S, Pieruzzi F, et al. L. Insulin resistance, prehypertension, hypertension and blood pressure values in paediatric age. J Hypertens. 2012;30:327–35.PubMedCrossRef
49.
go back to reference Dalziel SR, Parag V, Rodgers A, Harding JE. Cardiovascular risk factors at age 30 following pre-term birth. Int J Epidemiol. 2007;36:907–15.PubMedCrossRef Dalziel SR, Parag V, Rodgers A, Harding JE. Cardiovascular risk factors at age 30 following pre-term birth. Int J Epidemiol. 2007;36:907–15.PubMedCrossRef
50.
go back to reference Kistner A, Celsi G, Vanpee M, Jacobson SH. Increased blood pressure but normal renal function in adult women born preterm. Pediatr Nephrol. 2000;15:215–20.PubMedCrossRef Kistner A, Celsi G, Vanpee M, Jacobson SH. Increased blood pressure but normal renal function in adult women born preterm. Pediatr Nephrol. 2000;15:215–20.PubMedCrossRef
51.
go back to reference Doyle LW, Faber B, Callanan C, Morley R. Blood pressure in late adolescence and very low birth weight. Pediatrics. 2003;111:252–7.PubMedCrossRef Doyle LW, Faber B, Callanan C, Morley R. Blood pressure in late adolescence and very low birth weight. Pediatrics. 2003;111:252–7.PubMedCrossRef
52.
go back to reference Mathai S, Derraik JG, Cutfield WS, Dalziel SR, Harding JE, Biggs JB, et al. Blood pressure abnormalities in adults born moderately preterm and their children. Int J Cardiol. 2015;181:152–4.PubMedCrossRef Mathai S, Derraik JG, Cutfield WS, Dalziel SR, Harding JE, Biggs JB, et al. Blood pressure abnormalities in adults born moderately preterm and their children. Int J Cardiol. 2015;181:152–4.PubMedCrossRef
53.
go back to reference Singhal A, Kattenhorn M, Cole TJ, Deanfield J, Lucas A. Preterm birth, vascular function, and risk factors for atherosclerosis. Lancet. 2001;358:1159–60.PubMedCrossRef Singhal A, Kattenhorn M, Cole TJ, Deanfield J, Lucas A. Preterm birth, vascular function, and risk factors for atherosclerosis. Lancet. 2001;358:1159–60.PubMedCrossRef
54.
go back to reference He FJ, Li J, Macgregor GA. Effect of longer-term modest salt reduction on blood pressure. Cochrane Database Syst Rev. 2013;30(4):CD004937. He FJ, Li J, Macgregor GA. Effect of longer-term modest salt reduction on blood pressure. Cochrane Database Syst Rev. 2013;30(4):CD004937.
55.
go back to reference Tabara Y, Takahashi Y, Kumagai K, Seton K, Kawaguchi T, Takahashi M, et al. Descriptive epidemiology of spot urine sodium-to-potassium ratio clarified close relationship with blood pressure level: the Nagahama study. J Hypertens. 2015;33:2407–13.PubMedCrossRef Tabara Y, Takahashi Y, Kumagai K, Seton K, Kawaguchi T, Takahashi M, et al. Descriptive epidemiology of spot urine sodium-to-potassium ratio clarified close relationship with blood pressure level: the Nagahama study. J Hypertens. 2015;33:2407–13.PubMedCrossRef
56.
go back to reference Urbina E, Alpert B, Flynn J, Hayman L, Harshfield GA, Jacobson M, et al. Ambulatory blood pressure monitoring in children and adolescents: recommendations for standard assessment: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young and the Council for High Blood Pressure Research. Hypertension. 2008;52:433–51.PubMedCrossRef Urbina E, Alpert B, Flynn J, Hayman L, Harshfield GA, Jacobson M, et al. Ambulatory blood pressure monitoring in children and adolescents: recommendations for standard assessment: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young and the Council for High Blood Pressure Research. Hypertension. 2008;52:433–51.PubMedCrossRef
57.
go back to reference Wühl E, Witte K, Soergel M, Mehls O. Schaefer F; German Working Group on Pediatric Hypertension. Distribution of 24-h ambulatory blood pressure in children: normalized reference values and role of body dimensions [published correction appears in J Hypertens. 2003;21:2205–2206]. J Hypertens. 2002;20:1995–2007.PubMedCrossRef Wühl E, Witte K, Soergel M, Mehls O. Schaefer F; German Working Group on Pediatric Hypertension. Distribution of 24-h ambulatory blood pressure in children: normalized reference values and role of body dimensions [published correction appears in J Hypertens. 2003;21:2205–2206]. J Hypertens. 2002;20:1995–2007.PubMedCrossRef
58.
go back to reference National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents. Pediatrics. 2004;114:555–76.CrossRef National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents. Pediatrics. 2004;114:555–76.CrossRef
59.
go back to reference Koshy S, Macarthur C, Luthra S, Gajaria M, Geary D. Ambulatory blood pressure monitoring: mean blood pressure and blood pressure load. Pediatr Nephrol. 2005;20:1484–6.PubMedCrossRef Koshy S, Macarthur C, Luthra S, Gajaria M, Geary D. Ambulatory blood pressure monitoring: mean blood pressure and blood pressure load. Pediatr Nephrol. 2005;20:1484–6.PubMedCrossRef
60.
go back to reference White WB, Dey HM, Schulman P. Assessment of the daily blood pressure load as a determinant of cardiac function in patients with mild-to-moderate hypertension. Am Heart J. 1989;118:782–95.PubMedCrossRef White WB, Dey HM, Schulman P. Assessment of the daily blood pressure load as a determinant of cardiac function in patients with mild-to-moderate hypertension. Am Heart J. 1989;118:782–95.PubMedCrossRef
61.
go back to reference Flynn JT, Daniels SR, Hayman LL, Maahs DM, McCrindle BW, Mitsnefes M, et al. American Heart Association Atherosclerosis, Hypertension and Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young. Update: ambulatory blood pressure monitoring in children and adolescents: a scientific statement from the American Heart Association. Hypertension. 2014;63:1116–35.PubMedPubMedCentralCrossRef Flynn JT, Daniels SR, Hayman LL, Maahs DM, McCrindle BW, Mitsnefes M, et al. American Heart Association Atherosclerosis, Hypertension and Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young. Update: ambulatory blood pressure monitoring in children and adolescents: a scientific statement from the American Heart Association. Hypertension. 2014;63:1116–35.PubMedPubMedCentralCrossRef
62.
go back to reference Juonala M, Magnussen CG, Venn A, Dwyer T, Burns TL, Davis PH, et al. Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Bogalusa Heart Study, and the Muscatine Study for the international Childhood Cardiovascular Cohort (i3C) Consortium. Circulation. 2010;122:2514–20.PubMedCrossRef Juonala M, Magnussen CG, Venn A, Dwyer T, Burns TL, Davis PH, et al. Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Bogalusa Heart Study, and the Muscatine Study for the international Childhood Cardiovascular Cohort (i3C) Consortium. Circulation. 2010;122:2514–20.PubMedCrossRef
63.
go back to reference Koivistoinen T, Hutri-Kähönen N, Juonala M, Aatola H, Kööbi T, Lehtimäki T, et al. Metabolic syndrome in childhood and increased arterial stiffness in adulthood: the Cardiovascular Risk in Young Finns Study. Ann Med. 2011;43:312–9.PubMedCrossRef Koivistoinen T, Hutri-Kähönen N, Juonala M, Aatola H, Kööbi T, Lehtimäki T, et al. Metabolic syndrome in childhood and increased arterial stiffness in adulthood: the Cardiovascular Risk in Young Finns Study. Ann Med. 2011;43:312–9.PubMedCrossRef
64.
go back to reference Li X, Li S, Ulusoy E, Chen W, Srinivasan SR, Berenson GS. Childhood adiposity as a predictor of cardiac mass in adulthood: the Bogalusa Heart Study. Circulation. 2004;110:3488–92.PubMedCrossRef Li X, Li S, Ulusoy E, Chen W, Srinivasan SR, Berenson GS. Childhood adiposity as a predictor of cardiac mass in adulthood: the Bogalusa Heart Study. Circulation. 2004;110:3488–92.PubMedCrossRef
65.
go back to reference Sorof JM, Cardwell G, Franco K, Portman RJ. Ambulatory blood pressure and left ventricular mass index in hypertensive children. Hypertension. 2002;39:903–8.PubMedCrossRef Sorof JM, Cardwell G, Franco K, Portman RJ. Ambulatory blood pressure and left ventricular mass index in hypertensive children. Hypertension. 2002;39:903–8.PubMedCrossRef
66.
go back to reference McNiece KL, Gupta-Malhotra M, Samuels J, Bell C, Garcia K, Poffenbarger T, et al. Left ventricular hypertrophy in hypertensive adolescents: analysis of risk by 2004 National High Blood Pressure Education Program Working Group staging criteria. Hypertension. 2007;50:392–5.PubMedPubMedCentralCrossRef McNiece KL, Gupta-Malhotra M, Samuels J, Bell C, Garcia K, Poffenbarger T, et al. Left ventricular hypertrophy in hypertensive adolescents: analysis of risk by 2004 National High Blood Pressure Education Program Working Group staging criteria. Hypertension. 2007;50:392–5.PubMedPubMedCentralCrossRef
67.
go back to reference Stergiou GS, Giovas PP, Kollias A, Rarra VC, Papagiannis J, Georgakopoulos D, et al. Relationship of home blood pressure with target-organ damage in children and adolescents. Hypertens Res. 2011;34:640–4.PubMedCrossRef Stergiou GS, Giovas PP, Kollias A, Rarra VC, Papagiannis J, Georgakopoulos D, et al. Relationship of home blood pressure with target-organ damage in children and adolescents. Hypertens Res. 2011;34:640–4.PubMedCrossRef
68.
go back to reference Lengyel S, Katona E, Zatik J, Molnár C, Paragh G, Fülesdi B, et al. The impact of serum homocysteine on intima-media thickness in normotensive, white-coat and sustained hypertensive adolescents. Blood Press. 2012;21:39–44.PubMedCrossRef Lengyel S, Katona E, Zatik J, Molnár C, Paragh G, Fülesdi B, et al. The impact of serum homocysteine on intima-media thickness in normotensive, white-coat and sustained hypertensive adolescents. Blood Press. 2012;21:39–44.PubMedCrossRef
69.
go back to reference Stabouli S, Kotsis V, Papamichael C, Constantopoulos A, Zakopoulos N. Adolescent obesity is associated with high ambulatory blood pressure and increased carotid intimal-medial thickness. J Pediatr. 2005;147:651–6.PubMedCrossRef Stabouli S, Kotsis V, Papamichael C, Constantopoulos A, Zakopoulos N. Adolescent obesity is associated with high ambulatory blood pressure and increased carotid intimal-medial thickness. J Pediatr. 2005;147:651–6.PubMedCrossRef
70.
go back to reference Litwin M, Niemirska A, Sladowska J, Antoniewicz J, Daszkowska J, Wierzbicka A, et al. Left ventricular hypertrophy and arterial wall thickening in children with essential hypertension. pressure with target-organ damage in children and adolescents. Pediatr Nephrol. 2006;21:811–9.PubMedCrossRef Litwin M, Niemirska A, Sladowska J, Antoniewicz J, Daszkowska J, Wierzbicka A, et al. Left ventricular hypertrophy and arterial wall thickening in children with essential hypertension. pressure with target-organ damage in children and adolescents. Pediatr Nephrol. 2006;21:811–9.PubMedCrossRef
71.
go back to reference Mitsnefes MM, Kimball TR, Witt SA, Glascock BJ, Khoury PR, Daniels SR. Abnormal carotid artery structure and function in children and adolescents with successful renal transplantation. Circulation. 2004;110:97–101.PubMedCrossRef Mitsnefes MM, Kimball TR, Witt SA, Glascock BJ, Khoury PR, Daniels SR. Abnormal carotid artery structure and function in children and adolescents with successful renal transplantation. Circulation. 2004;110:97–101.PubMedCrossRef
72.
go back to reference Aggoun Y, Farpour-Lambert NJ, Marchand LM, Golay E, Maggio ABR, Beghetti M. Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure. Eur Heart J. 2008;29:792–9.PubMedCrossRef Aggoun Y, Farpour-Lambert NJ, Marchand LM, Golay E, Maggio ABR, Beghetti M. Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure. Eur Heart J. 2008;29:792–9.PubMedCrossRef
73.
go back to reference Ettinger LM, Freeman K, DiMartino-Nardi JR, Flynn JT. Microalbuminuria and abnormal ambulatory blood pressure in adolescents with type 2 diabetes mellitus. J Pediatr. 2005;147:67–73.PubMedCrossRef Ettinger LM, Freeman K, DiMartino-Nardi JR, Flynn JT. Microalbuminuria and abnormal ambulatory blood pressure in adolescents with type 2 diabetes mellitus. J Pediatr. 2005;147:67–73.PubMedCrossRef
74.
go back to reference Lurbe E, Redon J, Kesani A, Pascual JM, Tacons J, Alvarez V, et al. Increase in nocturnal blood pressure and progression to microalbuminuria in type 1 diabetes. N Engl J Med. 2002;347:797–805.PubMedCrossRef Lurbe E, Redon J, Kesani A, Pascual JM, Tacons J, Alvarez V, et al. Increase in nocturnal blood pressure and progression to microalbuminuria in type 1 diabetes. N Engl J Med. 2002;347:797–805.PubMedCrossRef
75.
go back to reference Samuels J, Ng D, Flynn JT, Mitsnefes M, Poffenbarger T, Warady BA, et al. Chronic Kidney Disease in Children Study Group. Ambulatory blood pressure patterns in children with chronic kidney disease. Hypertension. 2012;60:43–50.PubMedPubMedCentralCrossRef Samuels J, Ng D, Flynn JT, Mitsnefes M, Poffenbarger T, Warady BA, et al. Chronic Kidney Disease in Children Study Group. Ambulatory blood pressure patterns in children with chronic kidney disease. Hypertension. 2012;60:43–50.PubMedPubMedCentralCrossRef
76.
go back to reference McGlothan KR, Wyatt RJ, Ault BH, Hastings MC, Rogers T, Di Sessa T, et al. Predominance of nocturnal hypertension in pediatric renal allograft recipients. Pediatr Transplant. 2006;10:558–64.PubMedCrossRef McGlothan KR, Wyatt RJ, Ault BH, Hastings MC, Rogers T, Di Sessa T, et al. Predominance of nocturnal hypertension in pediatric renal allograft recipients. Pediatr Transplant. 2006;10:558–64.PubMedCrossRef
77.
go back to reference Lande MB, Meagher CC, Fisher SG, Belani P, Wang H, Rashid M. Left ventricular mass index in children with white coat hypertension. J Pediatr. 2008;153:50–4.PubMedPubMedCentralCrossRef Lande MB, Meagher CC, Fisher SG, Belani P, Wang H, Rashid M. Left ventricular mass index in children with white coat hypertension. J Pediatr. 2008;153:50–4.PubMedPubMedCentralCrossRef
78.
go back to reference Páll D, Juhász M, Lengyel S, Molnár C, Paragh G, Fülesdi B, et al. Assessment of target-organ damage in adolescent white-coat and sustained hypertensives. J Hypertens. 2010;28:2139–44.PubMedCrossRef Páll D, Juhász M, Lengyel S, Molnár C, Paragh G, Fülesdi B, et al. Assessment of target-organ damage in adolescent white-coat and sustained hypertensives. J Hypertens. 2010;28:2139–44.PubMedCrossRef
79.
go back to reference Kavey RE, Kveselis DA, Atallah N, Smith FC. White coat hypertension in childhood: evidence for end-organ effect. J Pediatr. 2007;150:491–7.PubMedCrossRef Kavey RE, Kveselis DA, Atallah N, Smith FC. White coat hypertension in childhood: evidence for end-organ effect. J Pediatr. 2007;150:491–7.PubMedCrossRef
80.
go back to reference Litwin M, Niemirska A, Ruzicka M, Feber J. White coat hypertension in children: not rare and not benign? J Am Soc Hypertens. 2009;3:416–23.PubMedCrossRef Litwin M, Niemirska A, Ruzicka M, Feber J. White coat hypertension in children: not rare and not benign? J Am Soc Hypertens. 2009;3:416–23.PubMedCrossRef
81.
go back to reference Sorof JM, Poffenbarger T, Franco K, Portman R. Evaluation of whitecoat hypertension in children: Importance of the definitions of normal ambulatory blood pressure and the severity of casual hypertension. Am J Hypertens. 2001;14:855–60.PubMedCrossRef Sorof JM, Poffenbarger T, Franco K, Portman R. Evaluation of whitecoat hypertension in children: Importance of the definitions of normal ambulatory blood pressure and the severity of casual hypertension. Am J Hypertens. 2001;14:855–60.PubMedCrossRef
82.
go back to reference Lurbe E, Torro I, Alvarez V, Nawrot T, Paya R, Redon J, Staessen JA. Prevalence, persistence, and clinical significance of masked hypertension. Hypertension. 2005;45:493–8.PubMedCrossRef Lurbe E, Torro I, Alvarez V, Nawrot T, Paya R, Redon J, Staessen JA. Prevalence, persistence, and clinical significance of masked hypertension. Hypertension. 2005;45:493–8.PubMedCrossRef
83.
go back to reference Stabouli S, Kotsis V, Toumanidis S, Papamichael C, Constantopoulos A, Zakopoulos N. White-coat and masked hypertension in children: association with target-organ damage. Pediatr Nephrol. 2005;20:1151–5.PubMedCrossRef Stabouli S, Kotsis V, Toumanidis S, Papamichael C, Constantopoulos A, Zakopoulos N. White-coat and masked hypertension in children: association with target-organ damage. Pediatr Nephrol. 2005;20:1151–5.PubMedCrossRef
84.
go back to reference Salice P, Ardissino G, Barbier P, Bacà L, Vecchi DL, Ghiglia S, et al. A Differences between office and ambulatory blood pressures in children and adolescents attending a hospital hypertension clinic. J Hypertens. 2013;31:2165–75.PubMedCrossRef Salice P, Ardissino G, Barbier P, Bacà L, Vecchi DL, Ghiglia S, et al. A Differences between office and ambulatory blood pressures in children and adolescents attending a hospital hypertension clinic. J Hypertens. 2013;31:2165–75.PubMedCrossRef
85.
go back to reference Flynn JT. Differentiation between primary and secondary hypertension in children using ambulatory blood pressure monitoring. Pediatrics. 2002;110:89–93.PubMedCrossRef Flynn JT. Differentiation between primary and secondary hypertension in children using ambulatory blood pressure monitoring. Pediatrics. 2002;110:89–93.PubMedCrossRef
86.
go back to reference Flynn JT, Alderman MH. Characteristics of children with primary hypertension seen at a referral center. Pediatr Nephrol. 2005;20:961–6.PubMedCrossRef Flynn JT, Alderman MH. Characteristics of children with primary hypertension seen at a referral center. Pediatr Nephrol. 2005;20:961–6.PubMedCrossRef
87.
go back to reference Sorof JM, Turner J, Franco K, Portman RJ. Characteristics of hypertensive children identified by primary care referral compared with school-based screening. J Pediatr. 2004;144:485–9.PubMedCrossRef Sorof JM, Turner J, Franco K, Portman RJ. Characteristics of hypertensive children identified by primary care referral compared with school-based screening. J Pediatr. 2004;144:485–9.PubMedCrossRef
88.
go back to reference Cai L, Wu Y, Wilson RF, Segal JB, Kim MT, Wang Y. Effect of childhood obesity prevention programs on blood pressure. A systematic review and meta-analysis. Circulation. 2014;129:1832–9.PubMedPubMedCentralCrossRef Cai L, Wu Y, Wilson RF, Segal JB, Kim MT, Wang Y. Effect of childhood obesity prevention programs on blood pressure. A systematic review and meta-analysis. Circulation. 2014;129:1832–9.PubMedPubMedCentralCrossRef
89.
go back to reference Ingelfinger JR. Pediatric antecedents of adult cardiovascular disease: awareness and intervention. N Engl J Med. 2004;350:2123–6.PubMedCrossRef Ingelfinger JR. Pediatric antecedents of adult cardiovascular disease: awareness and intervention. N Engl J Med. 2004;350:2123–6.PubMedCrossRef
90.
go back to reference Garcia-Hermoso A, Saavedra JM, Escalante Y. Effect of exercise on resting blood pressure in obese children: a meta-analysis of randomized controlled trials. Obesity Rev. 2013;14:919–28.CrossRef Garcia-Hermoso A, Saavedra JM, Escalante Y. Effect of exercise on resting blood pressure in obese children: a meta-analysis of randomized controlled trials. Obesity Rev. 2013;14:919–28.CrossRef
92.
go back to reference Meyer F, Bar-Or O, MacDougall D, Heigenhauser GJ. Sweat electrolyte loss during exercise in the heat: effects of gender and maturation. Med Sci Sports Exerc. 1992;24:776–81.PubMedCrossRef Meyer F, Bar-Or O, MacDougall D, Heigenhauser GJ. Sweat electrolyte loss during exercise in the heat: effects of gender and maturation. Med Sci Sports Exerc. 1992;24:776–81.PubMedCrossRef
94.
go back to reference Iglayreger HB, Peterson MD, Liu D, Parker CA, Woolford SJ, Sallinen Gafka BJ, et al. Sleep duration predicts cardiometabolic risk in obese adolescents. J Pediatr. 2014;164:1085–1090.e1.PubMedPubMedCentralCrossRef Iglayreger HB, Peterson MD, Liu D, Parker CA, Woolford SJ, Sallinen Gafka BJ, et al. Sleep duration predicts cardiometabolic risk in obese adolescents. J Pediatr. 2014;164:1085–1090.e1.PubMedPubMedCentralCrossRef
95.
go back to reference Archbold KH, Vasquez MM, Goodwin JL, Quan SF. Effects of sleep patterns and obesity on increases in blood pressure in a 5-year period: report from the Tucson Children’s Assessment of Sleep Apnea Study. J Pediatr. 2012;161:26–30.PubMedPubMedCentralCrossRef Archbold KH, Vasquez MM, Goodwin JL, Quan SF. Effects of sleep patterns and obesity on increases in blood pressure in a 5-year period: report from the Tucson Children’s Assessment of Sleep Apnea Study. J Pediatr. 2012;161:26–30.PubMedPubMedCentralCrossRef
96.
go back to reference Stone MR, Stevens D, Faulkner GE. Maintaining recommended sleep throughout the week is associated with increased physical activity in children. Prev Med. 2013;56:112–7.PubMedCrossRef Stone MR, Stevens D, Faulkner GE. Maintaining recommended sleep throughout the week is associated with increased physical activity in children. Prev Med. 2013;56:112–7.PubMedCrossRef
97.
go back to reference Magee C, Caputi P, Iverson D. Lack of sleep could increase obesity in children and too much television could be partly to blame. Acta Paediatr. 2014;103:e27–31.PubMedCrossRef Magee C, Caputi P, Iverson D. Lack of sleep could increase obesity in children and too much television could be partly to blame. Acta Paediatr. 2014;103:e27–31.PubMedCrossRef
98.
go back to reference Whelton SP, Chin A, Xin X, He J. Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials. Ann Intern Med. 2002;136:493–503.PubMedCrossRef Whelton SP, Chin A, Xin X, He J. Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials. Ann Intern Med. 2002;136:493–503.PubMedCrossRef
99.
go back to reference Semlitsch T, Jeitler K, Hemkens LG, Horvath K, Nagele E, Schuermann C, et al. A Increasing physical activity for the treatment of hypertension: a systematic review and meta-analysis. Sports Med. 2013;43:1009–23.PubMedCrossRef Semlitsch T, Jeitler K, Hemkens LG, Horvath K, Nagele E, Schuermann C, et al. A Increasing physical activity for the treatment of hypertension: a systematic review and meta-analysis. Sports Med. 2013;43:1009–23.PubMedCrossRef
100.
go back to reference Torrance B, McGuire KA, Lewanczuk R, McGavock J. Overweight, physical activity and high blood pressure in children: a review of the literature. Vasc Health Risk Manag. 2007;3:139–49.PubMedPubMedCentral Torrance B, McGuire KA, Lewanczuk R, McGavock J. Overweight, physical activity and high blood pressure in children: a review of the literature. Vasc Health Risk Manag. 2007;3:139–49.PubMedPubMedCentral
101.
go back to reference Flynn JT. Management of hypertension in children and adolescents in Clinic Pediatric Nephrology. In: Kanwal K, Sudesh Paul M, William H, editors. Informa Healthcare UK Ltd. Secondth ed. 2007. Flynn JT. Management of hypertension in children and adolescents in Clinic Pediatric Nephrology. In: Kanwal K, Sudesh Paul M, William H, editors. Informa Healthcare UK Ltd. Secondth ed. 2007.
102.
go back to reference Janssen I, Leblanc AG. Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. Int J Behav Nutr Phys Act. 2010;7:40.PubMedPubMedCentralCrossRef Janssen I, Leblanc AG. Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. Int J Behav Nutr Phys Act. 2010;7:40.PubMedPubMedCentralCrossRef
103.
go back to reference Puri M, Flynn JT. Management of Hypertension in Children and Adolescents With the Metabolic Syndrome. J Cardiometab Syndr. 2006;1:259–68.PubMedCrossRef Puri M, Flynn JT. Management of Hypertension in Children and Adolescents With the Metabolic Syndrome. J Cardiometab Syndr. 2006;1:259–68.PubMedCrossRef
104.
go back to reference Chen X, Wang Y. Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation. 2008;117:3171–80.PubMedPubMedCentralCrossRef Chen X, Wang Y. Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation. 2008;117:3171–80.PubMedPubMedCentralCrossRef
105.
go back to reference Verdecchia P, Gentile G, Angeli F, Mazzotta G, Mancia G, Reboldi G. Influence of blood pressure reduction on composite cardiovascular endpoints in clinical trials. J Hypertens. 2010;28:1356–65.PubMedCrossRef Verdecchia P, Gentile G, Angeli F, Mazzotta G, Mancia G, Reboldi G. Influence of blood pressure reduction on composite cardiovascular endpoints in clinical trials. J Hypertens. 2010;28:1356–65.PubMedCrossRef
106.
go back to reference Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents; National Heart, Lung, and Blood Institute. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents: Summary Report. Pediatrics. 2011;128 Suppl 5:S213–56.PubMedCentral Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents; National Heart, Lung, and Blood Institute. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents: Summary Report. Pediatrics. 2011;128 Suppl 5:S213–56.PubMedCentral
107.
go back to reference McCambridge TM, Benjamin HJ, Brenner JS, et al. Council on Sports Medicine and Fitness. Athletic participation by children and adolescents who have systemic hypertension. Pediatrics. 2010;125(6):1287–94.PubMedCrossRef McCambridge TM, Benjamin HJ, Brenner JS, et al. Council on Sports Medicine and Fitness. Athletic participation by children and adolescents who have systemic hypertension. Pediatrics. 2010;125(6):1287–94.PubMedCrossRef
108.
go back to reference Alpert BS. Exercise as a therapy to control hypertension in children. Int J Sports Med. 2000;21 suppl 2:S94–6. discussion S97.PubMedCrossRef Alpert BS. Exercise as a therapy to control hypertension in children. Int J Sports Med. 2000;21 suppl 2:S94–6. discussion S97.PubMedCrossRef
109.
go back to reference Pate RR, Matthews C, Alpert BS, Strong WB, DuRant RH. Systolic blood pressure response to exercise in black and white preadolescent and early adolescent boys. Arch Pediatr Adolesc Med. 1994;148:1027–31.PubMedCrossRef Pate RR, Matthews C, Alpert BS, Strong WB, DuRant RH. Systolic blood pressure response to exercise in black and white preadolescent and early adolescent boys. Arch Pediatr Adolesc Med. 1994;148:1027–31.PubMedCrossRef
110.
go back to reference MacDougall JD, Tuxen D, Sale DG, Moroz JR, Sutton JR. Arterial blood pressure response to heavy resistance exercise. J Appl Physiol. 1985;58:785–90.PubMed MacDougall JD, Tuxen D, Sale DG, Moroz JR, Sutton JR. Arterial blood pressure response to heavy resistance exercise. J Appl Physiol. 1985;58:785–90.PubMed
111.
go back to reference Mitchell JH, Haskell W, Snell P, Van Camp SP. Task Force 8: Classification of Sports. J Am Coll Cardiol. 2005;45:1364–7.PubMedCrossRef Mitchell JH, Haskell W, Snell P, Van Camp SP. Task Force 8: Classification of Sports. J Am Coll Cardiol. 2005;45:1364–7.PubMedCrossRef
112.
go back to reference American Academy of Pediatrics Council on Sports Medicine and Fitness. Policy statement – athletic participation by children and adolescents who have systemic hypertension. Pediatrics. 2010;125:1287–94.CrossRef American Academy of Pediatrics Council on Sports Medicine and Fitness. Policy statement – athletic participation by children and adolescents who have systemic hypertension. Pediatrics. 2010;125:1287–94.CrossRef
113.
go back to reference Comitato Organizzativo Cardiologico per l’Idoneità allo Sport ANCE, ANMCO, FMSI, SIC, SIC SPORT. Protocolli cardiologici per il giudizio di idoneità allo sport agonistico 2009. Casa Editrice Scientifica Internazionale. Comitato Organizzativo Cardiologico per l’Idoneità allo Sport ANCE, ANMCO, FMSI, SIC, SIC SPORT. Protocolli cardiologici per il giudizio di idoneità allo sport agonistico 2009. Casa Editrice Scientifica Internazionale.
114.
go back to reference Decreto-legge 13 settembre 2012, n. 158, e successive modifiche recante “Disposizioni urgenti per promuovere lo sviluppo del Paese mediante un più alto livello di tutela della salute”. Decreto-legge 13 settembre 2012, n. 158, e successive modifiche recante “Disposizioni urgenti per promuovere lo sviluppo del Paese mediante un più alto livello di tutela della salute”.
115.
go back to reference Marriott BP, Olsho L, Hadden L, Connor P. Intake of added sugars and selected nutrients in the United States, National Health and Nutrition Examination Survey (NHANES) 2003–2006. Crit Rev Food Sci Nutr. 2010;50:228–58.PubMedCrossRef Marriott BP, Olsho L, Hadden L, Connor P. Intake of added sugars and selected nutrients in the United States, National Health and Nutrition Examination Survey (NHANES) 2003–2006. Crit Rev Food Sci Nutr. 2010;50:228–58.PubMedCrossRef
116.
go back to reference Malik VS, Schulze MB, Hu FB. Intake of sugar-sweetened beverages and weight gain: a systematic review. Am J Clin Nutr. 2006;84:274–88.PubMedPubMedCentral Malik VS, Schulze MB, Hu FB. Intake of sugar-sweetened beverages and weight gain: a systematic review. Am J Clin Nutr. 2006;84:274–88.PubMedPubMedCentral
117.
go back to reference Sievenpiper JL, de Souza RJ, Mirrahimi A, Yu ME, Carleton AJ, Beyene J, et al. Effect of fructose on body weight in controlled feeding trials: a systematic review and meta-analysis. Ann Intern Med. 2012;156:291–304.PubMedCrossRef Sievenpiper JL, de Souza RJ, Mirrahimi A, Yu ME, Carleton AJ, Beyene J, et al. Effect of fructose on body weight in controlled feeding trials: a systematic review and meta-analysis. Ann Intern Med. 2012;156:291–304.PubMedCrossRef
118.
go back to reference Bray GA. Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people. Adv Nutr. 2013;4:220–5.PubMedPubMedCentralCrossRef Bray GA. Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people. Adv Nutr. 2013;4:220–5.PubMedPubMedCentralCrossRef
119.
go back to reference Spagnolo A, Giussani M, Ambruzzi AM, Bianchetti M, Maringhini S, Matteucci MC, et al. Focus on prevention, diagnosis and treatment of hypertension in children and adolescents. Ital J Pediatr. 2013;39:20.PubMedPubMedCentralCrossRef Spagnolo A, Giussani M, Ambruzzi AM, Bianchetti M, Maringhini S, Matteucci MC, et al. Focus on prevention, diagnosis and treatment of hypertension in children and adolescents. Ital J Pediatr. 2013;39:20.PubMedPubMedCentralCrossRef
120.
go back to reference Mennella JA, Finkbeiner S, Lipchock SV, Hwang LD, Reed DR. Preferences for salty and sweet tastes are elevated and related to each other during childhood. PLoS One. 2014;9:e92201.PubMedPubMedCentralCrossRef Mennella JA, Finkbeiner S, Lipchock SV, Hwang LD, Reed DR. Preferences for salty and sweet tastes are elevated and related to each other during childhood. PLoS One. 2014;9:e92201.PubMedPubMedCentralCrossRef
121.
go back to reference Grimes CA, Riddell LJ, Campbell KJ, Nowson CA. Dietary salt intake, sugar-sweetened beverage consumption, and obesity risk. Pediatrics. 2013;131:14–21.PubMedCrossRef Grimes CA, Riddell LJ, Campbell KJ, Nowson CA. Dietary salt intake, sugar-sweetened beverage consumption, and obesity risk. Pediatrics. 2013;131:14–21.PubMedCrossRef
122.
go back to reference Cohen JC, Schall R. Reassessing the effects of simple carbohydrates on the serum triglyceride responses to fat meals. Am J Clin Nutr. 1988;48:1031–4.PubMed Cohen JC, Schall R. Reassessing the effects of simple carbohydrates on the serum triglyceride responses to fat meals. Am J Clin Nutr. 1988;48:1031–4.PubMed
123.
go back to reference Stirpe F, Della Corte E, Bonetti E, Abbondanza A, Abbati A, De Stefano F. Fructose-induced hyperuricaemia. Lancet. 1970;2:1310–1.PubMedCrossRef Stirpe F, Della Corte E, Bonetti E, Abbondanza A, Abbati A, De Stefano F. Fructose-induced hyperuricaemia. Lancet. 1970;2:1310–1.PubMedCrossRef
124.
go back to reference Hu QH, Wang C, Li JM, Zhang DM, Kong LD. Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement. Am J Physiol Renal Physiol. 2009;297:F1080–1091.PubMedCrossRef Hu QH, Wang C, Li JM, Zhang DM, Kong LD. Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement. Am J Physiol Renal Physiol. 2009;297:F1080–1091.PubMedCrossRef
125.
go back to reference Teff KL, Elliott SS, Tschöp M, Kieffer TJ, Rader D, Heiman M, et al. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab. 2004;89:2963–72.PubMedCrossRef Teff KL, Elliott SS, Tschöp M, Kieffer TJ, Rader D, Heiman M, et al. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab. 2004;89:2963–72.PubMedCrossRef
126.
go back to reference Jürgens H, Haass W, Castañeda TR, Schürmann A, Koebnick C, Dombrowski F, et al. Consuming fructose-sweetened beverages increases body adiposity in mice. Obes Res. 2005;13:1146–56.PubMedCrossRef Jürgens H, Haass W, Castañeda TR, Schürmann A, Koebnick C, Dombrowski F, et al. Consuming fructose-sweetened beverages increases body adiposity in mice. Obes Res. 2005;13:1146–56.PubMedCrossRef
127.
go back to reference Singh AK, Amlal H, Haas PJ, Dringenberg U, Fussell S, Barone SL, et al. Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5. Kidney Int. 2008;74:438–47.PubMedCrossRef Singh AK, Amlal H, Haas PJ, Dringenberg U, Fussell S, Barone SL, et al. Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5. Kidney Int. 2008;74:438–47.PubMedCrossRef
128.
go back to reference Madero M, Perez-Pozo SE, Jalal D, Johnson RJ, Sánchez-Lozada LG. Dietary Fructose and Hypertension. Curr Hypertens Rep. 2011;13:29–35.PubMedCrossRef Madero M, Perez-Pozo SE, Jalal D, Johnson RJ, Sánchez-Lozada LG. Dietary Fructose and Hypertension. Curr Hypertens Rep. 2011;13:29–35.PubMedCrossRef
129.
go back to reference Sánchez-Lozada LG, Tapia E, Jiménez A, Bautista P, Cristóbal M, Nepomuceno T, et al. Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am J Physiol Renal Physiol. 2007;292:F423–429.PubMedCrossRef Sánchez-Lozada LG, Tapia E, Jiménez A, Bautista P, Cristóbal M, Nepomuceno T, et al. Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am J Physiol Renal Physiol. 2007;292:F423–429.PubMedCrossRef
130.
go back to reference Choi JW, Ford ES, Gao X, Choi HK. Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third National Health and Nutrition Examination Survey. Arthritis Rheum. 2008;59:109–16.PubMedCrossRef Choi JW, Ford ES, Gao X, Choi HK. Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third National Health and Nutrition Examination Survey. Arthritis Rheum. 2008;59:109–16.PubMedCrossRef
131.
132.
go back to reference Johnson RJ, Nakagawa T, Sanchez-Lozada LG, Shafiu M, Sundaram S, Le M, et al. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes. 2013;62:3307–15.PubMedPubMedCentralCrossRef Johnson RJ, Nakagawa T, Sanchez-Lozada LG, Shafiu M, Sundaram S, Le M, et al. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes. 2013;62:3307–15.PubMedPubMedCentralCrossRef
133.
go back to reference Feig DI, Madero M, Jalal DI, Sanchez-Lozada LG, Johnson RJ. Uric acid and the origins of hypertension. J Pediatr. 2013;162:896–902.PubMedCrossRef Feig DI, Madero M, Jalal DI, Sanchez-Lozada LG, Johnson RJ. Uric acid and the origins of hypertension. J Pediatr. 2013;162:896–902.PubMedCrossRef
134.
go back to reference Corry DB, Eslami P, Yamamoto K, Nyby MD, Makino H, Tuck ML. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system. J Hypertens. 2008;26:269–75.PubMedCrossRef Corry DB, Eslami P, Yamamoto K, Nyby MD, Makino H, Tuck ML. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system. J Hypertens. 2008;26:269–75.PubMedCrossRef
136.
go back to reference Kang DH, Han L, Ouyang X, Kahn AM, Kanellis J, Li P, et al. Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter. Am J Nephrol. 2005;25:425–33.PubMedCrossRef Kang DH, Han L, Ouyang X, Kahn AM, Kanellis J, Li P, et al. Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter. Am J Nephrol. 2005;25:425–33.PubMedCrossRef
137.
go back to reference Baldwin W, McRae S, Marek G, Wymer D, Pannu V, Baylis C, et al. Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes. 2011;60:1258–69.PubMedPubMedCentralCrossRef Baldwin W, McRae S, Marek G, Wymer D, Pannu V, Baylis C, et al. Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes. 2011;60:1258–69.PubMedPubMedCentralCrossRef
138.
go back to reference Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, et al. A role for uric acid in the progression of renal disease. J Am Soc Nephrol. 2002;13:2888–97.PubMedCrossRef Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, et al. A role for uric acid in the progression of renal disease. J Am Soc Nephrol. 2002;13:2888–97.PubMedCrossRef
139.
go back to reference Kosugi T, Nakayama T, Heinig M, Zhang L, Yuzawa Y, Sanchez-Lozada LG, et al. Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice. Am J Physiol Renal Physiol. 2009;297:F481–8.PubMedPubMedCentralCrossRef Kosugi T, Nakayama T, Heinig M, Zhang L, Yuzawa Y, Sanchez-Lozada LG, et al. Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice. Am J Physiol Renal Physiol. 2009;297:F481–8.PubMedPubMedCentralCrossRef
140.
go back to reference Verzola D, Ratto E, Villaggio B, Parodi EL, Pontremoli R, Garibotto G, Viazzi F. Uric acid promotes apoptosis in human proximal tubule cells by oxidative stress and the activation of NADPH oxidase NOX 4. PLoS One. 2014;9:e115210.PubMedPubMedCentralCrossRef Verzola D, Ratto E, Villaggio B, Parodi EL, Pontremoli R, Garibotto G, Viazzi F. Uric acid promotes apoptosis in human proximal tubule cells by oxidative stress and the activation of NADPH oxidase NOX 4. PLoS One. 2014;9:e115210.PubMedPubMedCentralCrossRef
141.
go back to reference Johnson RJ, Nakagawa T, Jalal D, Sánchez-Lozada LG, Kang DH, Ritz E. Uric acid and chronic kidney disease: which is chasing which? Nephrol Dial Transplant. 2013;28:2221–8.PubMedPubMedCentralCrossRef Johnson RJ, Nakagawa T, Jalal D, Sánchez-Lozada LG, Kang DH, Ritz E. Uric acid and chronic kidney disease: which is chasing which? Nephrol Dial Transplant. 2013;28:2221–8.PubMedPubMedCentralCrossRef
142.
go back to reference AlKhater SA. Paediatric non-alcoholic fatty liver disease: an overview. Obes Rev. 2015;16:393–405.PubMedCrossRef AlKhater SA. Paediatric non-alcoholic fatty liver disease: an overview. Obes Rev. 2015;16:393–405.PubMedCrossRef
143.
go back to reference Xu CF, Yu CH, Xu L, Sa XY, Li YM. Hypouricemic therapy: a novel potential therapeutic option for nonalcoholic fatty liver disease. Hepatology. 2010;52:1865–6.PubMedCrossRef Xu CF, Yu CH, Xu L, Sa XY, Li YM. Hypouricemic therapy: a novel potential therapeutic option for nonalcoholic fatty liver disease. Hepatology. 2010;52:1865–6.PubMedCrossRef
144.
go back to reference Kanbay M, Segal M, Afsar B, Kang DH, Rodriguez-Iturbe B, Johnson RJ. The role of uric acid in the pathogenesis of human cardiovascular disease. Heart. 2013;99:759–66.PubMedCrossRef Kanbay M, Segal M, Afsar B, Kang DH, Rodriguez-Iturbe B, Johnson RJ. The role of uric acid in the pathogenesis of human cardiovascular disease. Heart. 2013;99:759–66.PubMedCrossRef
145.
go back to reference Wang J, Qin T, Chen J, Li Y, Wang L, Huang H, Li J. Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies. PLoS One. 2014;9:e114259.PubMedPubMedCentralCrossRef Wang J, Qin T, Chen J, Li Y, Wang L, Huang H, Li J. Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies. PLoS One. 2014;9:e114259.PubMedPubMedCentralCrossRef
146.
go back to reference Ford ES, Li C, Cook S, Choi HK. Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation. 2007;115:2526–32.PubMedCrossRef Ford ES, Li C, Cook S, Choi HK. Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation. 2007;115:2526–32.PubMedCrossRef
147.
go back to reference Pacifico L, Cantisani V, Anania C, Bonaiuto E, Martino F, Pascone R, Chiesa C. Serum uric acid and its association with metabolic syndrome and carotid atherosclerosis in obese children. Eur J Endocrinol. 2009;160:45–52.PubMedCrossRef Pacifico L, Cantisani V, Anania C, Bonaiuto E, Martino F, Pascone R, Chiesa C. Serum uric acid and its association with metabolic syndrome and carotid atherosclerosis in obese children. Eur J Endocrinol. 2009;160:45–52.PubMedCrossRef
148.
go back to reference Hongo M, Hidaka H, Sakaguchi S, Nakanishi K, Ichikawa M, Hirota N, et al. Investigators of Study Project on Prevention of Metabolic Syndrome among Children, Adolescents, and Young Adults in Shinshu. Association between serum uric acid levels and cardiometabolic risk factors among Japanese junior high school students. Circ J. 2010;74:1570–7.PubMedCrossRef Hongo M, Hidaka H, Sakaguchi S, Nakanishi K, Ichikawa M, Hirota N, et al. Investigators of Study Project on Prevention of Metabolic Syndrome among Children, Adolescents, and Young Adults in Shinshu. Association between serum uric acid levels and cardiometabolic risk factors among Japanese junior high school students. Circ J. 2010;74:1570–7.PubMedCrossRef
150.
go back to reference Jones DP, Richey PA, Alpert BS, Li R. Serum uric acid and ambulatory blood pressure in children with primary hypertension. Pediatr Res. 2008;64:556–61.PubMedPubMedCentralCrossRef Jones DP, Richey PA, Alpert BS, Li R. Serum uric acid and ambulatory blood pressure in children with primary hypertension. Pediatr Res. 2008;64:556–61.PubMedPubMedCentralCrossRef
151.
go back to reference Loeffler LF, Navas-Acien A, Brady TM, Miller 3rd ER, Fadrowski JJ. Uric acid level and elevated blood pressure in US adolescents: National Health and Nutrition Examination Survey, 1999–2006. Hypertension. 2012;59:811–7.PubMedPubMedCentralCrossRef Loeffler LF, Navas-Acien A, Brady TM, Miller 3rd ER, Fadrowski JJ. Uric acid level and elevated blood pressure in US adolescents: National Health and Nutrition Examination Survey, 1999–2006. Hypertension. 2012;59:811–7.PubMedPubMedCentralCrossRef
152.
go back to reference Viazzi F, Antolini L, Giussani M, Brambilla P, Galbiati S, Mastriani S, Stella A, Pontremoli R, Valsecchi MG, Genovesi S. Serum uric acid and blood pressure in children at cardiovascular risk. Pediatrics. 2013;132:e93–99.PubMedCrossRef Viazzi F, Antolini L, Giussani M, Brambilla P, Galbiati S, Mastriani S, Stella A, Pontremoli R, Valsecchi MG, Genovesi S. Serum uric acid and blood pressure in children at cardiovascular risk. Pediatrics. 2013;132:e93–99.PubMedCrossRef
153.
go back to reference Alper Jr AB, Chen W, Yau L, Srinivasan SR, Berenson GS, Hamm LL. Childhood uric acid predicts adult blood pressure: the Bogalusa Heart Study. Hypertension. 2005;45:34–8.PubMedCrossRef Alper Jr AB, Chen W, Yau L, Srinivasan SR, Berenson GS, Hamm LL. Childhood uric acid predicts adult blood pressure: the Bogalusa Heart Study. Hypertension. 2005;45:34–8.PubMedCrossRef
154.
155.
go back to reference Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA. 2008;300:924–32.PubMedPubMedCentralCrossRef Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA. 2008;300:924–32.PubMedPubMedCentralCrossRef
156.
go back to reference Soletsky B, Feig DI. Uric acid reduction rectifies prehypertension in obese adolescents. Hypertension. 2012;60:1148–56.PubMedCrossRef Soletsky B, Feig DI. Uric acid reduction rectifies prehypertension in obese adolescents. Hypertension. 2012;60:1148–56.PubMedCrossRef
157.
go back to reference Viazzi F, Rebora P, Giussani M, Orlando A, Stella A, Antolini L, Valsecchi MG, Pontremoli R, Genovesi S. Increased Serum Uric Acid Levels Blunt the Antihypertensive Efficacy of Lifestyle Modifications in Children at Cardiovascular Risk. Hypertension. 2016;67:934–40.PubMedCrossRef Viazzi F, Rebora P, Giussani M, Orlando A, Stella A, Antolini L, Valsecchi MG, Pontremoli R, Genovesi S. Increased Serum Uric Acid Levels Blunt the Antihypertensive Efficacy of Lifestyle Modifications in Children at Cardiovascular Risk. Hypertension. 2016;67:934–40.PubMedCrossRef
158.
go back to reference Zuccotti GV, Cassatella C, Morelli A, Cucugliato MC, Catinello G, del Balzo V, et al. Nutrient intake in Italian infants and toddlers from North and South Italy: the Nutrintake 636 study. Nutrients. 2014;6:3169–86.PubMedPubMedCentralCrossRef Zuccotti GV, Cassatella C, Morelli A, Cucugliato MC, Catinello G, del Balzo V, et al. Nutrient intake in Italian infants and toddlers from North and South Italy: the Nutrintake 636 study. Nutrients. 2014;6:3169–86.PubMedPubMedCentralCrossRef
Metadata
Title
Novelty in hypertension in children and adolescents: focus on hypertension during the first year of life, use and interpretation of ambulatory blood pressure monitoring, role of physical activity in prevention and treatment, simple carbohydrates and uric acid as risk factors
Authors
Mirella Strambi
Marco Giussani
Maria Amalia Ambruzzi
Paolo Brambilla
Ciro Corrado
Ugo Giordano
Claudio Maffeis
Silvio Maringhin
Maria Chiara Matteucci
Ettore Menghetti
Patrizia Salice
Federico Schena
Pietro Strisciuglio
Giuliana Valerio
Francesca Viazzi
Raffaele Virdis
Simonetta Genovesi
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2016
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-016-0277-0

Other articles of this Issue 1/2016

Italian Journal of Pediatrics 1/2016 Go to the issue