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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2019

Open Access 01-12-2019 | Lymphoma | Review

Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL)

Authors: Nagavalli Somasundaram, Jing Quan Lim, Choon Kiat Ong, Soon Thye Lim

Published in: Journal of Hematology & Oncology | Issue 1/2019

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Abstract

Natural killer T cell lymphoma (NKTL) is an aggressive disease with very poor treatment outcomes in the advanced stages. With chemotherapy, initial response rates to treatment are high but responses are short lived. A better understanding of the complex molecular pathogenesis of this disease is essential in order to design and develop better therapeutics with improved efficacy. This review aims to summarise the key pathogenic mechanisms in NKTL which may have significant prognostic and therapeutic implications.
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Metadata
Title
Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL)
Authors
Nagavalli Somasundaram
Jing Quan Lim
Choon Kiat Ong
Soon Thye Lim
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2019
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-019-0717-6

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