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International Journal of Hematology
Published in: International Journal of Hematology 2/2008

Open Access 01-03-2008 | Review Article

Nasal NK/T-cell lymphoma: epidemiology and pathogenesis

Authors: Katsuyuki Aozasa, Tetsuya Takakuwa, Tadashi Hongyo, Woo-Ick Yang

Published in: International Journal of Hematology | Issue 2/2008

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Abstract

Nasal NK/T-cell lymphoma (NKTCL) is an uncommon disease, but usually shows a highly aggressive clinical course. The disease is much more frequent in Asian and Latin American countries than in Western countries, and is universally associated with Epstein–Barr virus (EBV) infection. Analyses of gene mutations, especially p53 and c-KIT, revealed the different frequencies by district. Epidemiological studies revealed the changes of the disease frequency in Korea during the period from 1977–1989 to 1990–1996. Case-control study showed that the exposure to pesticides and chemical solvents could be causative of NKTCL. Further studies including HLA antigen typing of patients is necessary to further clarify the disease mechanism.
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Metadata
Title
Nasal NK/T-cell lymphoma: epidemiology and pathogenesis
Authors
Katsuyuki Aozasa
Tetsuya Takakuwa
Tadashi Hongyo
Woo-Ick Yang
Publication date
01-03-2008
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 2/2008
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-008-0021-7

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