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Open Access 01-12-2022 | Alzheimer's Disease | Perspective

APOE targeting strategy in Alzheimer’s disease: lessons learned from protective variants

Author: Guojun Bu

Published in: Molecular Neurodegeneration | Issue 1/2022

Excerpt

The APOE gene is the strongest genetic risk factor for Alzheimer’s disease (AD) with the ε4 allele increasing the risk by 2-4 folds compared to the most common ε3 allele [1]. The high prevalence of APOE4 allele frequency (~ 14% in Caucasian non-demented versus ~ 38% in AD) and carrier frequency (~ 20-30% in Caucasian non-demented versus 50-70% in AD) in AD patients presents a strong rationale to target APOE for AD prevention and therapy [1]. More interestingly, carriers of the APOE2 allele have a significantly reduced risk for AD [2], further attracting interests to target this strong AD risk gene. …

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Title: APOE targeting strategy in Alzheimer’s disease: lessons learned from protective variants
Author: Guojun Bu
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Alzheimer's Disease
Dementia
Alzheimer's Disease
Dementia
Published in: Molecular Neurodegeneration / Issue 1/2022
Electronic ISSN: 1750-1326
DOI: https://doi.org/10.1186/s13024-022-00556-6

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APOE targeting strategy in Alzheimer’s disease: lessons learned from protective variants

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