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AIDS Research and Therapy
Published in: AIDS Research and Therapy 1/2020

01-12-2020 | Mood Disorders | Review

Food insecurity and the risk of depression in people living with HIV/AIDS: a systematic review and meta-analysis

Authors: Getinet Ayano, Light Tsegay, Melat Solomon

Published in: AIDS Research and Therapy | Issue 1/2020

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Abstract

Background

The link between food insecurity and depression in people living with HIV/AIDS (PLWHA) has been explored in numerous studies; however, the existing evidence is inconclusive due to inconsistent results. Therefore, the objective of this systematic review and meta-analysis is to examine the relationship between food insecurity and depression in PLWHA.

Methods

We systematically searched PubMed, EMBASE, and Scopus to identify relevant studies. A random-effect model was used for conducting the meta-analysis. We assessed the risk of publication bias by funnel plot and Egger’s regression asymmetry test.

Results

In this review, seven studies were included in the final analysis. Our meta-analysis revealed that food insecurity significantly increased the risk of depression in PLWHA [RR 2.28 (95% CI 1.56–3.32)]. This association remained significant after adjusting for the confounding effects of drug use [RR 1.63 (95% CI 1.27–2.10)], social support [RR 2.21 (95% CI 1.18–4.16)] as well as ART drugs [RR 1.96 (95% CI 1.17–3.28)]. Our subgroup and sensitivity confirmed the robustness of the main analysis.

Conclusion

This systematic review and meta-analysis suggest a significant association between food insecurity and increased risk of depression PLWHA. Therefore, early screening and management of food insecurity in PLWHA seem to be necessary.
Appendix
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Metadata
Title
Food insecurity and the risk of depression in people living with HIV/AIDS: a systematic review and meta-analysis
Authors
Getinet Ayano
Light Tsegay
Melat Solomon
Publication date
01-12-2020
Publisher
BioMed Central
Published in
AIDS Research and Therapy / Issue 1/2020
Electronic ISSN: 1742-6405
DOI
https://doi.org/10.1186/s12981-020-00291-2

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