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AIDS Research and Therapy
Published in: AIDS Research and Therapy 1/2020

Open Access 01-12-2020 | Metformin | Review

Metformin effect on gut microbiota: insights for HIV-related inflammation

Authors: Jing Ouyang, Stéphane Isnard, John Lin, Brandon Fombuena, André Marette, Bertrand Routy, Yaokai Chen, Jean-Pierre Routy

Published in: AIDS Research and Therapy | Issue 1/2020

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Abstract

The gut microbiota is emerging as a prominent player in maintaining health through several metabolic and immune pathways. Dysregulation of gut microbiota composition, also known as dysbiosis, is involved in the clinical outcome of diabetes, inflammatory bowel diseases, cancer, aging and HIV infection. Gut dysbiosis and inflammation persist in people living with HIV (PLWH) despite receiving antiretroviral therapy, further contributing to non-AIDS comorbidities. Metformin, a widely used antidiabetic agent, has been found to benefit microbiota composition, promote gut barrier integrity and reduce inflammation in human and animal models of diabetes. Inspired by the effect of metformin on diabetes-related gut dysbiosis, we herein critically review the relevance of metformin to control inflammation in PLWH. Metformin may improve gut microbiota composition, in turn reducing inflammation and risk of non-AIDS comorbidities. This review will pave the way towards innovative strategies to counteract dysregulated microbiota and improve the lives of PLWH.
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Metadata
Title
Metformin effect on gut microbiota: insights for HIV-related inflammation
Authors
Jing Ouyang
Stéphane Isnard
John Lin
Brandon Fombuena
André Marette
Bertrand Routy
Yaokai Chen
Jean-Pierre Routy
Publication date
01-12-2020
Publisher
BioMed Central
Published in
AIDS Research and Therapy / Issue 1/2020
Electronic ISSN: 1742-6405
DOI
https://doi.org/10.1186/s12981-020-00267-2

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Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
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