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Journal of the International Society of Sports Nutrition
Published in: Journal of the International Society of Sports Nutrition 1/2016

Open Access 01-12-2016 | Review

Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance

Author: Peter Bond

Published in: Journal of the International Society of Sports Nutrition | Issue 1/2016

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Abstract

The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) plays a pivotal role in the regulation of skeletal muscle protein synthesis. Activation of the complex leads to phosphorylation of two important sets of substrates, namely eIF4E binding proteins and ribosomal S6 kinases. Phosphorylation of these substrates then leads to an increase in protein synthesis, mainly by enhancing translation initiation. mTORC1 activity is regulated by several inputs, such as growth factors, energy status, amino acids and mechanical stimuli. Research in this field is rapidly evolving and unraveling how these inputs regulate the complex. Therefore this review attempts to provide a brief and up-to-date narrative on the regulation of this marvelous protein complex. Additionally, some sports supplements which have been shown to regulate mTORC1 activity are discussed.
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Metadata
Title
Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance
Author
Peter Bond
Publication date
01-12-2016
Publisher
BioMed Central
DOI
https://doi.org/10.1186/s12970-016-0118-y

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