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Molecular Cancer
Published in: Molecular Cancer 1/2021

Open Access 01-12-2021 | Metastasis | Review

Expression profiles, biological functions and clinical significance of circRNAs in bladder cancer

Authors: Xiaoqi Yang, Tao Ye, Haoran Liu, Peng Lv, Chen Duan, Xiaoliang Wu, Kehua Jiang, Hongyan Lu, Ding Xia, Ejun Peng, Zhiqiang Chen, Kun Tang, Zhangqun Ye

Published in: Molecular Cancer | Issue 1/2021

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Abstract

Circular RNAs (circRNAs), which are single-stranded closed-loop RNA molecules lacking terminal 5′ caps and 3′ poly(A) tails, are attracting increasing scientific attention for their crucial regulatory roles in the occurrence and development of various diseases. With the rapid development of high-throughput sequencing technologies, increasing numbers of differentially expressed circRNAs have been identified in bladder cancer (BCa) via exploration of the expression profiles of BCa and normal tissues and cell lines. CircRNAs are critically involved in BCa biological behaviours, including cell proliferation, tumour growth suppression, cell cycle arrest, apoptosis, invasion, migration, metastasis, angiogenesis, and cisplatin chemoresistance. Most of the studied circRNAs in BCa regulate cancer biological behaviours via miRNA sponging regulatory mechanisms. CircRNAs have been reported to be significantly associated with many clinicopathologic characteristics of BCa, including tumour size, grade, differentiation, and stage; lymph node metastasis; tumour numbers; distant metastasis; invasion; and recurrence. Moreover, circRNA expression levels can be used to predict BCa patients’ survival parameters, such as overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS). The abundance, conservation, stability, specificity and detectability of circRNAs render them potential diagnostic and prognostic biomarkers for BCa. Additionally, circRNAs play crucial regulatory roles upstream of various signalling pathways related to BCa carcinogenesis and progression, reflecting their potential as therapeutic targets for BCa. Herein, we briefly summarize the expression profiles, biological functions and mechanisms of circRNAs and the potential clinical applications of these molecules for BCa diagnosis, prognosis, and targeted therapy.
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Metadata
Title
Expression profiles, biological functions and clinical significance of circRNAs in bladder cancer
Authors
Xiaoqi Yang
Tao Ye
Haoran Liu
Peng Lv
Chen Duan
Xiaoliang Wu
Kehua Jiang
Hongyan Lu
Ding Xia
Ejun Peng
Zhiqiang Chen
Kun Tang
Zhangqun Ye
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2021
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-020-01300-8

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