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Molecular Cancer
Published in: Molecular Cancer 1/2019

Open Access 01-12-2019 | Hepatocellular Carcinoma | Review

The emerging role of microRNAs and long noncoding RNAs in drug resistance of hepatocellular carcinoma

Authors: Ling Wei, Xingwu Wang, Liyan Lv, Jibing Liu, Huaixin Xing, Yemei Song, Mengyu Xie, Tianshui Lei, Nasha Zhang, Ming Yang

Published in: Molecular Cancer | Issue 1/2019

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Abstract

Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the second most lethal human cancer. A portion of patients with advanced HCC can significantly benefit from treatments with sorafenib, adriamycin, 5-fluorouracil and platinum drugs. However, most HCC patients eventually develop drug resistance, resulting in a poor prognosis. The mechanisms involved in HCC drug resistance are complex and inconclusive. Human transcripts without protein-coding potential are known as noncoding RNAs (ncRNAs), including microRNAs (miRNAs), small nucleolar RNAs (snoRNAs), long noncoding RNAs (lncRNAs) and circular RNA (circRNA). Accumulated evidences demonstrate that several deregulated miRNAs and lncRNAs are important regulators in the development of HCC drug resistance which elucidates their potential clinical implications. In this review, we summarized the detailed mechanisms by which miRNAs and lncRNAs affect HCC drug resistance. Multiple tumor-specific miRNAs and lncRNAs may serve as novel therapeutic targets and prognostic biomarkers for HCC.
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Metadata
Title
The emerging role of microRNAs and long noncoding RNAs in drug resistance of hepatocellular carcinoma
Authors
Ling Wei
Xingwu Wang
Liyan Lv
Jibing Liu
Huaixin Xing
Yemei Song
Mengyu Xie
Tianshui Lei
Nasha Zhang
Ming Yang
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2019
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-019-1086-z

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