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Molecular Cancer
Published in: Molecular Cancer 1/2019

Open Access 01-12-2019 | Review

Exo-circRNAs: a new paradigm for anticancer therapy

Authors: Hetian Bai, Kexin Lei, Fei Huang, Zhou Jiang, Xikun Zhou

Published in: Molecular Cancer | Issue 1/2019

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Abstract

CircRNAs, as new members of long noncoding RNAs, have been the focus of recent investigation. CircRNAs feature a closed continuous loop structure without 5′-3′ polarity or a poly A tail. Many studies have reported the potential application of circRNAs in the clinic as new biomarkers and therapeutic targets in different diseases, especially for cancer. Additionally, the exosomes are important vehicles in cell-to-cell communication. And exo-circRNAs are circRNAs in exosomes which can be detected to provide additional evidence for conventional diagnostic methods and can be applied to suppress the malignant progress in cancer. In this review, we describe the biogenesis, characteristics, and functions of circRNAs and exosomes. Specifically, we present a comprehensive update of the promising role of exo-circRNAs in anticancer therapy.
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Metadata
Title
Exo-circRNAs: a new paradigm for anticancer therapy
Authors
Hetian Bai
Kexin Lei
Fei Huang
Zhou Jiang
Xikun Zhou
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2019
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-019-0986-2

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