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Molecular Cancer
Published in: Molecular Cancer 1/2019

Open Access 01-12-2019 | Gastric Cancer | Review

Biogenesis, functions and clinical significance of circRNAs in gastric cancer

Authors: Chan Shan, Yinfeng Zhang, Xiaodan Hao, Jinning Gao, Xinzhe Chen, Kun Wang

Published in: Molecular Cancer | Issue 1/2019

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Abstract

Gastric cancer (GC) is one of the most common malignant tumours in the world and has high morbidity and mortality. Circular RNAs (circRNAs) are a class of non-coding RNAs with covalently linked circular structures. In recent years, plentiful circRNAs have been discovered that participate in many biological processes, including the initiation and development of tumours. Increasing evidences suggest important biological functions of circRNAs, implying that circRNAs may serve as vital new biomarkers and targets for disease diagnosis and prognosis. Among these, circRNAs are tend to aberrantly expressed and are regarded as potential biomarkers in the carcinogenesis and progression of GC. This review systematically summarised the biogenesis, biological properties and functions of circRNAs, with a focus on their relationship with GC, as well as their probable clinical implications on GC. As our cognition of the relation between circRNAs and GC deepens, more molecular mechanisms of GC progression will be discovered, and new therapeutic strategies will be used for the prevention and treatment of GC.
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Metadata
Title
Biogenesis, functions and clinical significance of circRNAs in gastric cancer
Authors
Chan Shan
Yinfeng Zhang
Xiaodan Hao
Jinning Gao
Xinzhe Chen
Kun Wang
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2019
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-019-1069-0

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