Published in:
Open Access
01-12-2018 | Letter to the Editor
CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer
Authors:
Weiwei Tang, Kai Fu, Handong Sun, Dawei Rong, Hanjin Wang, Hongyong Cao
Published in:
Molecular Cancer
|
Issue 1/2018
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Abstract
CircRNA expression profiles for gastric cancer (GC) were screened using plasma samples from 10 GC patients with different TNM stages and 5 healthy individuals as controls. Results showed lower expression of circ-KIAA1244 in GC tissues, plasmas, and cells compare to normal controls. Further clinical data analysis demonstrated that a decreased expression of circ-KIAA1244 in plasmas was negatively correlated with TNM stage and lymphatic metastasis, and a shorter overall survival time of GC patients. Moreover, we found that circ-KIAA1244 could be detected in GC plasma exosomes and showed no obvious significance compared to the expression level in the corresponding plasmas. This study revealed a GC-tissues-derived circ-KIAA1244 could serve a novel circulating biomarker for detection of GC.