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Molecular Cancer
Published in: Molecular Cancer 1/2019

Open Access 01-12-2019 | Metastasis | Review

Exosomal circRNAs: biogenesis, effect and application in human diseases

Authors: Yangxia Wang, Jinbo Liu, Junfen Ma, Ting Sun, Quanbo Zhou, Weiwei Wang, Guixian Wang, Pingjun Wu, Haijiang Wang, Li Jiang, Weitang Yuan, Zhenqiang Sun, Liang Ming

Published in: Molecular Cancer | Issue 1/2019

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Abstract

Exosomes have emerged as critical mediators of intercellular communication, both locally and systemically, by regulating a diverse range of biological processes between cells. Circular RNA (circRNA) is a novel member of endogenous noncoding RNAs with widespread distribution and diverse cellular functions. Recently, circular RNAs have been identified for their enrichment and stability in exosomes. In this review, we outline the origin, biogenesis and function of exosomal circRNAs as well as their roles in various diseases. Although their precise roles and mechanisms of gene regulation remain largely elusive, exosomal circRNAs have potential applications as disease biomarkers and novel therapeutic targets.
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Metadata
Title
Exosomal circRNAs: biogenesis, effect and application in human diseases
Authors
Yangxia Wang
Jinbo Liu
Junfen Ma
Ting Sun
Quanbo Zhou
Weiwei Wang
Guixian Wang
Pingjun Wu
Haijiang Wang
Li Jiang
Weitang Yuan
Zhenqiang Sun
Liang Ming
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2019
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-019-1041-z

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