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Open Access 01-12-2019 | Metastasis | Review

Effects of exosomes on pre-metastatic niche formation in tumors

Authors: Yaxin Guo, Xiang Ji, Jinbo Liu, Dandan Fan, Quanbo Zhou, Chen Chen, Weiwei Wang, Guixian Wang, Haijiang Wang, Weitang Yuan, Zhenyu Ji, Zhenqiang Sun

Published in: Molecular Cancer | Issue 1/2019

Abstract

A pre-metastatic niche is a microenvironment prepared for the colonization of circulating tumor cells in specific organs. Exosomes are extracellular vesicles with a variety of biological functions. Exosomes play an irreplaceable role in the development of pre-metastatic niches, and mainly function as communication medium. In this review, we analyzed the effects of exosomes on pre-metastatic niches from various perspectives, including inflammation, immune response, angiogenesis, organotropism, matrix remodeling and biomarker expression. In particular, exosomes express programmed death ligand 1 (PD-L1) and cause the immune escape of tumor cells. The immunomodulatory effects of exosomes and their potential in liquid diagnosis have drawn our attention. The potential value of exosomes and pre-metastatic niches will be realized in the field of immunity therapy.

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Title: Effects of exosomes on pre-metastatic niche formation in tumors
Authors: Yaxin Guo
Xiang Ji
Jinbo Liu
Dandan Fan
Quanbo Zhou
Chen Chen
Weiwei Wang
Guixian Wang
Haijiang Wang
Weitang Yuan
Zhenyu Ji
Zhenqiang Sun
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Metastasis
Biomarkers
Published in: Molecular Cancer / Issue 1/2019
Electronic ISSN: 1476-4598
DOI: https://doi.org/10.1186/s12943-019-0995-1

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