Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Oral Health
Published in: BMC Oral Health 1/2023

Open Access 01-12-2023 | Research

Influence of inflammation on bleeding and wound healing following surgical extraction of impacted lower third molars

Authors: Yusheng Cheng, Maged Ali Al-Aroomi, Naseem Ali Al-Worafi, Essam Ahmed Al‑Moraissi, Changfu Sun

Published in: BMC Oral Health | Issue 1/2023

Login to get access

Abstract

Objective

This study aimed to investigate the effect of inflammatory states following impacted lower third molar (ILTM) surgery regarding postoperative bleeding and wound healing.

Methods

The study included patients who underwent extraction of ILTMs associated with or without inflammatory conditions. Post-extraction bleeding and wound healing were assessed. In addition, mean grey values (MGVs) of alveolar bone and bone height using an orthopantomography radiograph were analyzed.

Results

A total of 376 patients were enrolled; 171 pericoronitis, 51 pulpitis, 44 chronic periapical periodontitis, 36 chronic periodontitis, and 74 control. The bleeding score in the control group was significantly lower than in the periapical periodontitis and periodontitis groups. Excellent wound healing for control, pericoronitis, pulpitis, periapical periodontitis, and periodontitis groups was (78.38%, 35.67%, 70.59%, 70.45%, and 33.33%, respectively). Patients with pericoronitis and periodontitis had significantly poorer wound healing (P < 0.01). The MGV in periapical periodontitis and periodontitis was considerably lower than in the control group.

Conclusions

The inflammatory conditions associated with ILTMs increase the risk of bleeding. So suturing with the placement of local hemostatic agents over a pressure pack alone is recommended. The poorest wound healing was in localized gingival inflammation. Furthermore, MGV was affected by age and was lower with periapical periodontitis.
Literature
1.
Lysell L, Rohlin M. A study of indications used for removal of the mandibular third molar. Int J Oral Maxillofac Surg. 1988;17:161–4.CrossRefPubMed
2.
Wang C-C, Kok S-H, Hou L-T, Yang P-J, Lee J-J, Cheng S-J, et al. Ectopic mandibular third molar in the ramus region: report of a case and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2008;105:155–61.CrossRef
3.
Laino L, Menditti D, lo Muzio L, Laino G, Lauritano F, Cicciù M. Extraoral surgical approach of ectopic mandibular third molar to the lower border of mandible. J Craniofac Surg. 2015;26:e256–60.CrossRefPubMed
4.
Candotto V, Oberti L, Gabrione F, Scarano A, Rossi D, Romano M. Complication in third molar extractions. J Biol Regul Homeost Agents. 2019;33(3 Suppl. 1):169–72.PubMed
5.
Polat HB, Özan F, Kara I, Özdemir H, Ay S. Prevalence of commonly found pathoses associated with mandibular impacted third molars based on panoramic radiographs in Turkish population. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2008;105:e41–7.CrossRef
6.
Falci SGM, de Castro CR, Santos RC, de Souza Lima LD, Ramos-Jorge ML, Botelho AM, et al. Association between the presence of a partially erupted mandibular third molar and the existence of caries in the distal of the second molars. Int J Oral Maxillofac Surg. 2012;41:1270–4.CrossRefPubMed
7.
Al-Khateeb TH, Bataineh AB. Pathology associated with impacted mandibular third molars in a group of Jordanians. J Oral Maxillofac Surg. 2006;64:1598–602.CrossRefPubMed
8.
Pourmand PP, Sigron GR, Mache B, Stadlinger B, Locher MC. The most common complications after wisdom-tooth removal: part 2: a retrospective study of 1562 cases in the maxilla. Swiss Dent J. 2014;124:1047–61.PubMed
9.
Gersema L, Baker K. Use of corticosteroids in oral surgery. J Oral Maxillofac Surg. 1992;50:270–7.CrossRefPubMed
10.
Vezeau PJ. Dental extraction wound management: medicating postextraction sockets. J Oral Maxillofac Surg. 2000;58:531–7.CrossRefPubMed
11.
Pell GJ, Gregory GT. Report on a ten-year study of a tooth division technique for the removal of impacted teeth. Am J Orthod Oral Surg. 1942;28:B660–6.CrossRef
12.
Nourwali I. The effects of platelet-rich fibrin on post-surgical complications following removal of impacted wisdom teeth: a pilot study. J Taibah Univ Med Sci. 2021;16:521–8.PubMedPubMedCentral
13.
14.
Kaveri GS, Prakash S. Third molars: a threat to periodontal health? J Maxillofac Oral Surg. 2012;11:220–3.CrossRefPubMed
15.
Bui CH, Seldin EB, Dodson TB. Types, frequencies, and risk factors for complications after third molar extraction. J Oral Maxillofac Surg. 2003;61:1379–89.CrossRefPubMed
16.
Patel S, Mansuri S, Shaikh F, Shah T. Impacted mandibular third molars: a retrospective study of 1198 cases to assess indications for surgical removal, and correlation with age, sex and type of impaction—a single institutional experience. J Maxillofac Oral Surg. 2017;16:79–84.CrossRefPubMed
17.
Krishnan B, el Sheikh MH, Rafa E-G, Orafi H. Indications for removal of impacted mandibular third molars: a single institutional experience in Libya. J Maxillofac Oral Surg. 2009;8:246–8.CrossRefPubMedPubMedCentral
18.
Nagraj SK, Prashanti E, Aggarwal H, Lingappa A, Muthu MS, Krishanappa SKK, et al. Interventions for treating post‐extraction bleeding. Cochrane Database Syst Rev. 2018.
19.
Chiapasco M, de Cicco L, Marrone G. Side effects and complications associated with third molar surgery. Oral Surg Oral Med Oral Pathol. 1993;76:412–20.CrossRefPubMed
20.
Pachipulusu PK, Manjula S. Comparative study of primary and secondary closure of the surgical wound after removal of impacted mandibular third molars. Oral Maxillofac Surg. 2018;22:261–6.CrossRefPubMed
21.
Pasqualini D, Cocero N, Castella A, Mela L, Bracco P. Primary and secondary closure of the surgical wound after removal of impacted mandibular third molars: a comparative study. Int J Oral Maxillofac Surg. 2005;34:52–7.CrossRefPubMed
22.
Pagni G, Pellegrini G, Giannobile WV, Rasperini G. Postextraction alveolar ridge preservation: biological basis and treatments. Int J Dent. 2012;2012.
23.
Schropp L, Wenzel A, Kostopoulos L, Karring T. Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restor Dent. 2003;23.
24.
Chiapasco M, Rossi A, Motta JJ, Crescentini M. Spontaneous bone regeneration after enucleation of large mandibular cysts: a radiographic computed analysis of 27 consecutive cases. J Oral Maxillofac Surg. 2000;58:942–8.CrossRefPubMed
25.
Sharma A, Ingole S, Deshpande M, Ranadive P, Sharma S, Kazi N, et al. Influence of platelet-rich fibrin on wound healing and bone regeneration after tooth extraction: a clinical and radiographic study. J Oral Biol Craniofac Res. 2020;10:385–90.CrossRefPubMedPubMedCentral
26.
Ash MM, Costich ER, Hayward JR. A study of periodontal hazards of third molars. 1962.
27.
Ziegler RS. Preventive dentistry—new concepts. Preventing periodontal pockets. Va Dent J. 1975;52:11–3.PubMed
28.
Krausz AA, Machtei EE, Peled M. Effects of lower third molar extraction on attachment level and alveolar bone height of the adjacent second molar. Int J Oral Maxillofac Surg. 2005;34:756–60.CrossRefPubMed
Metadata
Title
Influence of inflammation on bleeding and wound healing following surgical extraction of impacted lower third molars
Authors
Yusheng Cheng
Maged Ali Al-Aroomi
Naseem Ali Al-Worafi
Essam Ahmed Al‑Moraissi
Changfu Sun
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-023-02754-0

Other articles of this Issue 1/2023

BMC Oral Health 1/2023 Go to the issue

Research

Clinical efficacy of bioactive restorative materials in controlling secondary caries: a systematic review and network meta-analysis

Research

Diagnostic potential of miR-200 family members in gingival crevicular fluid for chronic periodontitis: correlation with clinical parameters and therapeutic implications

Research

The salivary proteome in relation to oral mucositis in autologous hematopoietic stem cell transplantation recipients: a labelled and label-free proteomics approach

Research

Barriers and enablers for oral health promotion programs amongst primary healthcare stakeholders in Qatar – a qualitative investigation

Study Protocol

Prevention of caries and obesity in children with immigrant background in Norway- a study protocol for a cluster randomized controlled trial

Research

CD79A work as a potential target for the prognosis of patients with OSCC: analysis of immune cell infiltration in oral squamous cell carcinoma based on the CIBERSORTx deconvolution algorithm