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Open Access 01-12-2016 | Research article

Interocular anatomical and visual functional differences in pediatric patients with unilateral cataracts

Authors: Erping Long, Jingjing Chen, Zhenzhen Liu, Zhuoling Lin, Qianzhong Cao, Xiayin Zhang, Xiaoyan Li, Lixia Luo, Haotian Lin, Weirong Chen, Yizhi Liu

Published in: BMC Ophthalmology | Issue 1/2016

Abstract

Background

Congenital cataracts are often complicated by anterior segment dysgenesis. This study aims to compare bilateral anterior segment parameters, macular thickness, and best-corrected visual acuity (BCVA) in pediatric cataract patients at 3 months after unilateral cataract extraction with intraocular lens implantation.

Methods

Fifty-three pediatric patients with uncomplicated unilateral total cataracts were included. At 3 months post-surgery, bilateral corneal thickness at the thinnest location (CTTL), anterior chamber depth (ACD), and anterior chamber volume (ACV) were measured using Pentacam. Central macular thickness (CMT) was evaluated using spectral-domain optical coherence tomography. BCVA was measured by experienced optometrists concurrently. Descriptive statistics and bivariate corrections were performed to analyze the interocular differences in bilateral anatomic parameters and their relationships with BCVA.

Results

For all 53 included patients (mean age 5.2 ± 2.3 years), the median BCVA was 10/40 in the operated eyes and 40/40 in the contralateral eyes, which indicates a significant interocular difference. BCVA values in the contralateral eyes were significantly correlated with patient age at surgery, but this result differed for BCVA in the operated eyes. The Pentacam analysis revealed no significant interocular differences in bilateral CTTL and ACV, but significant differences were found for ACD.

Conclusions

At 3 months after surgery, unilateral pediatric cataract patients exhibited no significant interocular differences in identified anatomical parameters (except for ACD), and these parameters were not significantly correlated with BCVA in bilateral eyes. Therefore, amblyopia, but not anatomical factors, might be the main cause of interocular visual functional differences in our study population.

Trial registration

ClinicalTrial.gov, NCT02765230, 05/05/2016, retrospectively registered.

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Title: Interocular anatomical and visual functional differences in pediatric patients with unilateral cataracts
Authors: Erping Long
Jingjing Chen
Zhenzhen Liu
Zhuoling Lin
Qianzhong Cao
Xiayin Zhang
Xiaoyan Li
Lixia Luo
Haotian Lin
Weirong Chen
Yizhi Liu
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: BMC Ophthalmology / Issue 1/2016
Electronic ISSN: 1471-2415
DOI: https://doi.org/10.1186/s12886-016-0371-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Interocular anatomical and visual functional differences in pediatric patients with unilateral cataracts

Abstract

Background

Methods

Results

Conclusions

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

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