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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 12/2013

01-12-2013 | Pediatrics

Spectral-domain optical coherence tomography analysis in deprivational amblyopia: a pilot study with unilateral pediatric cataract patients

Authors: Yong Woo Kim, Seong-Joon Kim, Young Suk Yu

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 12/2013

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Abstract

Background

To investigate whether macular and peripapillary retinal nerve fiber layer (RNFL) structure differs among deprivational amblyopic eyes, fellow non-amblyopic eyes, and age-matched normal eyes, using spectral-domain optical coherence tomography (SD-OCT).

Methods

Macula and optic disc of 14 unilateral pseudophakic children with deprivational amblyopia, and 14 age-matched normal children (mean age, 7.45 ± 2.57 years) were scanned with CirrusTM HD-OCT. Macular, RNFL, and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses were measured, and compared between the eyes after correction for axial length-related magnification errors.

Results

The average RNFL thickness tended to be greater in amblyopic eyes (99.64 ± 10.11 μm) than in fellow non-amblyopic eyes (97.28 ± 12.34 μm) and normal eyes (95.38 ± 9.74 μm), but did not show statistical significance (p = 0.429, p = 0.286 respectively). The nasal RNFL thickness was significantly greater in amblyopic eyes (75.84 ± 19.22 μm) than in fellow non-amblyopic eyes (63.42 ± 14.05 μm, p = 0.037) and normal eyes (62.38 ± 9.65 μm, p = 0.043). The central macular thickness in amblyopic eyes (237.05 ± 37.74 μm) showed no significant differences compared to those of fellow non-amblyopic eyes (226.67 ± 34.71 μm) and normal eyes (233.74 ± 27.11 μm) (p = 0.137, p = 0.792 respectively). The macular GCIPL thickness showed no significant difference among the amblyopic, fellow non-amblyopic, and normal eyes (average; 78.94 ± 6.35 μm vs 78.77 ± 6.43 μm vs 82.22 ± 5.00 μm respectively, p > 0.05).

Conclusions

SD-OCT analysis of deprivational amblyopic eyes with unilateral pediatric cataract demonstrated significant increase in nasal RNFL thickness compared to fellow non-amblyopic eyes and age-matched normal eyes. The macular and macular GCIPL thickness did not show any significant difference. Taken together, monocular pattern deprivation in early childhood may have changed the nasal peripapillary RNFL structure.
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Metadata
Title
Spectral-domain optical coherence tomography analysis in deprivational amblyopia: a pilot study with unilateral pediatric cataract patients
Authors
Yong Woo Kim
Seong-Joon Kim
Young Suk Yu
Publication date
01-12-2013
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 12/2013
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-013-2494-1

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