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BMC Neurology
Published in: BMC Neurology 1/2023

Open Access 01-12-2023 | Intracranial Aneurysm | Case report

Aneurysmal subarachnoid hemorrhage with PFBC and beta thalassemia: a case report

Authors: Kuangyang Yu, Jinwei Pang, Xiaobo Yang, Jianhua Peng, Yong Jiang

Published in: BMC Neurology | Issue 1/2023

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Abstract

Background

Primary familial brain calcification (PFBC), habitually called Fahr’s disease, is characterized by bilateral calcification of the basal ganglia, accompanied by extensive calcification of the cerebellar dentate nucleus, brainstem cerebrum, and cerebellum at the grey-white matter junction. However, there are few reports about PFBC with aneurysmal subarachnoid hemorrhage (aSAH) and thalassemia.

Case presentation

We describe a patient admitted to the hospital with an acute deterioration in the level of consciousness with no history of neuropsychiatric features or movement disorders. After computed tomography (CT) and CT angiography (CTA), the patient was diagnosed with PFBC, accompanied by aneurysmal subarachnoid haemorrhage (aSAH), intracranial haemorrhage (ICH), and hemoglobin electrophoresis suggested beta-thalassemia. This patient underwent craniotomy aneurysm clipping and intracranial hematoma removal.

Conclusions

For patients with PFBC, we should pay attention to their blood pressure and intracranial vascular conditions. The CTA is necessary to clarify the cerebrovascular conditions of the patient, especially when combined with hypertension and persistent headache or other related prodromal symptoms of cerebrovascular disease.
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Metadata
Title
Aneurysmal subarachnoid hemorrhage with PFBC and beta thalassemia: a case report
Authors
Kuangyang Yu
Jinwei Pang
Xiaobo Yang
Jianhua Peng
Yong Jiang
Publication date
01-12-2023

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