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Open Access 01-12-2020 | Central Nervous System Trauma | Review article

Persistent post-traumatic headache: a migrainous loop or not? The preclinical evidence

Authors: Silvia Benemei, Alejandro Labastida-Ramírez, Ekaterina Abramova, Nicoletta Brunelli, Edoardo Caronna, Paola Diana, Roman Gapeshin, Maxi Dana Hofacker, Ilaria Maestrini, Enrique Martínez Pías, Petr Mikulenka, Olga Tikhonova, Paolo Martelletti, Antoinette MaassenVanDenBrink, On behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)

Published in: The Journal of Headache and Pain | Issue 1/2020

Abstract

Background

According to the International Classification of Headache Disorders 3, post-traumatic headache (PTH) attributed to traumatic brain injury (TBI) is a secondary headache reported to have developed within 7 days from head injury, regaining consciousness following the head injury, or discontinuation of medication(s) impairing the ability to sense or report headache following the head injury. It is one of the most common secondary headache disorders, and it is defined as persistent when it lasts more than 3 months.

Main body

Currently, due to the high prevalence of this disorder, several preclinical studies have been conducted using different animal models of mild TBI to reproduce conditions that engender PTH. Despite representing a simplification of a complex disorder and displaying different limitations concerning the human condition, animal models are still a mainstay to study in vivo the mechanisms of PTH and have provided valuable insight into the pathophysiology and possible treatment strategies. Different models reproduce different types of trauma and have been ideated in order to ensure maximal proximity to the human condition and optimal experimental reproducibility.

Conclusion

At present, despite its high prevalence, PTH is not entirely understood, and the differential contribution of pathophysiological mechanisms, also observed in other conditions like migraine, has to be clarified. Although facing limitations, animal models are needed to improve understanding of PTH. The knowledge of currently available models is necessary to all researchers who want to investigate PTH and contribute to unravel its mechanisms.

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Title: Persistent post-traumatic headache: a migrainous loop or not? The preclinical evidence
Authors: Silvia Benemei
Alejandro Labastida-Ramírez
Ekaterina Abramova
Nicoletta Brunelli
Edoardo Caronna
Paola Diana
Roman Gapeshin
Maxi Dana Hofacker
Ilaria Maestrini
Enrique Martínez Pías
Petr Mikulenka
Olga Tikhonova
Paolo Martelletti
Antoinette MaassenVanDenBrink
On behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)
Publication date: 01-12-2020
Publisher: Springer Milan
Keywords: Central Nervous System Trauma
Migraine
Headache
Published in: The Journal of Headache and Pain / Issue 1/2020
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-020-01135-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Persistent post-traumatic headache: a migrainous loop or not? The preclinical evidence

Abstract

Background

Main body

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Main body

Conclusion

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