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01-12-2008 | Review

Clinical review: Critical illness polyneuropathy and myopathy

Authors: Greet Hermans, Bernard De Jonghe, Frans Bruyninckx, Greet Van den Berghe

Published in: Critical Care | Issue 6/2008

Abstract

Critical illness polyneuropathy (CIP) and myopathy (CIM) are major complications of severe critical illness and its management. CIP/CIM prolongs weaning from mechanical ventilation and physical rehabilitation since both limb and respiratory muscles can be affected. Among many risk factors implicated, sepsis, systemic inflammatory response syndrome, and multiple organ failure appear to play a crucial role in CIP/CIM. This review focuses on epidemiology, diagnostic challenges, the current understanding of pathophysiology, risk factors, important clinical consequences, and potential interventions to reduce the incidence of CIP/CIM. CIP/CIM is associated with increased hospital and intensive care unit (ICU) stays and increased mortality rates. Recently, it was shown in a single centre that intensive insulin therapy significantly reduced the electrophysiological incidence of CIP/CIM and the need for prolonged mechanical ventilation in patients in a medical or surgical ICU for at least 1 week. The electrophysiological diagnosis was limited by the fact that muscle membrane inexcitability was not detected. These results have yet to be confirmed in a larger patient population. One of the main risks of this therapy is hypoglycemia. Also, conflicting evidence concerning the neuromuscular effects of corticosteroids exists. A systematic review of the available literature on the optimal approach for preventing CIP/CIM seems warranted.

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Bolton CF, Laverty DA, Brown JD, Witt NJ, Hahn AF, Sibbald WJ: Critically ill polyneuropathy: electrophysiological studies and differentiation from Guillain-Barre syndrome. J Neurol Neurosurg Psychiatry 1986, 49: 563-573. 10.1136/jnnp.49.5.563PubMedCentralCrossRefPubMed

Zochodne DW, Bolton CF, Thompson RT, Driedger AA, Hahn AF, Gilbert JJ: Myopathy in critical illness. Muscle Nerve 1986, 9: 652.

Lacomis D, Zochodne DW, Bird SJ: Critical illness myopathy. Muscle Nerve 2000, 23: 1785-1788. 10.1002/1097-4598(200012)23:12<1785::AID-MUS1>3.0.CO;2-JCrossRefPubMed

Spitzer AR, Giancarlo T, Maher L, Awerbuch G, Bowles A: Neuromuscular causes of prolonged ventilator dependency. Muscle Nerve 1992, 15: 682-686. 10.1002/mus.880150609CrossRefPubMed

Faragher MW, Day BJ, Dennett X: Critical care myopathy: an electrophysiological and histological study. Muscle Nerve 1996, 19: 516-518. 10.1002/(SICI)1097-4598(199604)19:4<516::AID-MUS11>3.0.CO;2-NCrossRefPubMed

Williams S, Horrocks IA, Ouvrier RA, Gillis J, Ryan MM: Critical illness polyneuropathy and myopathy in pediatric intensive care: a review. Pediatr Crit Care Med 2007, 8: 18-22. 10.1097/01.pcc.0000256623.01254.40CrossRefPubMed

Bolton CF, Gilbert JJ, Hahn AF, Sibbald WJ: Polyneuropathy in critically ill patients. J Neurol Neurosurg Psychiatry 1984, 47: 1223-1231. 10.1136/jnnp.47.11.1223PubMedCentralCrossRefPubMed

Roelofs RI, Cerra F, Bielka N, Rosenberg L, Delaney J: Prolonged respiratory insufficiency due to acute motor neuropathy: a new syndrome? Neurology 1983, 33: 240.CrossRef

Zochodne DW, Bolton CF, Wells GA, Gilbert JJ, Hahn AF, Brown JD, Sibbald WA: Critical illness polyneuropathy. A complication of sepsis and multiple organ failure. Brain 1987, 110: 819-841. 10.1093/brain/110.4.819CrossRefPubMed

10.

Witt NJ, Zochodne DW, Bolton CF, Grand'Maison F, Wells G, Young GB, Sibbald WJ: Peripheral nerve function in sepsis and multiple organ failure. Chest 1991, 99: 176-184. 10.1378/chest.99.1.176CrossRefPubMed

11.

Bolton CF, Young GB, Zochodne DW: The neurological complications of sepsis. Ann Neurol 1993, 33: 94-100. 10.1002/ana.410330115CrossRefPubMed

12.

De Jonghe B, Sharshar T, Lefaucheur JP, Authier FJ, Durand-Zaleski I, Boussarsar M, Cerf C, Renaud E, Mesrati F, Carlet J, Raphaël JC, Outin H, Bastuji-Garin S, Groupe de Réflexion et d'Etude des Neuromyopathies en Réanimation: Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA 2002, 288: 2859-2867. 10.1001/jama.288.22.2859CrossRefPubMed

13.

Kleyweg RP, Meche FG, Schmitz PI: Interobserver agreement in the assessment of muscle strength and functional abilities in Guillain-Barre syndrome. Muscle Nerve 1991, 14: 1103-1109. 10.1002/mus.880141111CrossRefPubMed

14.

Pandit L, Agrawal A: Neuromuscular disorders in critical illness. Clin Neurol Neurosurg 2006, 108: 621-627. 10.1016/j.clineuro.2006.04.003CrossRefPubMed

15.

Latronico N, Fenzi F, Recupero D, Guarneri B, Tomelleri G, Tonin P, De Maria G, Antonini L, Rizzuto N, Candiani A: Critical illness myopathy and neuropathy. Lancet 1996, 347: 1579-1582. 10.1016/S0140-6736(96)91074-0CrossRefPubMed

16.

Khan J, Harrison TB, Rich MM, Moss M: Early development of critical illness myopathy and neuropathy in patients with severe sepsis. Neurology 2006, 67: 1421-1425. 10.1212/01.wnl.0000239826.63523.8eCrossRefPubMed

17.

Bednarik J, Lukas Z, Vondracek P: Critical illness polyneuromyopathy: the electrophysiological components of a complex entity. Intensive Care Med 2003, 29: 1505-1514. 10.1007/s00134-003-1858-0CrossRefPubMed

18.

Tennila A, Salmi T, Pettila V, Roine RO, Varpula T, Takkunen O: Early signs of critical illness polyneuropathy in ICU patients with systemic inflammatory response syndrome or sepsis. Intensive Care Med 2000, 26: 1360-1363. 10.1007/s001340000586CrossRefPubMed

19.

Cankayali I, Dogan YH, Solak I, Demirag K, Eris O, Demirgoren S, Moral AR: Neuromuscular deterioration in the early stage of sepsis in rats. Crit Care 2007, 11: R1. 10.1186/cc5139PubMedCentralCrossRefPubMed

20.

Latronico N, Bertolini G, Guarneri B, Botteri M, Peli E, Andreoletti S, Bera P, Luciani D, Nardella A, Vittorielli E, Simini B, Candiani A: Simplified electrophysiological evaluation of peripheral nerves in critically ill patients: the Italian multi-centre CRIMYNE study. Crit Care 2007, 11: R11. 10.1186/cc5671PubMedCentralCrossRefPubMed

21.

Coakley JH, Nagendran K, Yarwood GD, Honavar M, Hinds CJ: Patterns of neurophysiological abnormality in prolonged critical illness. Intensive Care Med 1998, 24: 801-807. 10.1007/s001340050669CrossRefPubMed

22.

Rich MM, Bird SJ, Raps EC, McCluskey LF, Teener JW: Direct muscle stimulation in acute quadriplegic myopathy. Muscle Nerve 1997, 20: 665-673. 10.1002/(SICI)1097-4598(199706)20:6<665::AID-MUS2>3.0.CO;2-6CrossRefPubMed

23.

Trojaborg W, Weimer LH, Hays AP: Electrophysiologic studies in critical illness associated weakness: myopathy or neuropathy – a reappraisal. Clin Neurophysiol 2001, 112: 1586-1593. 10.1016/S1388-2457(01)00572-7CrossRefPubMed

24.

Lefaucheur JP, Nordine T, Rodriguez P, Brochard L: Origin of ICU acquired paresis determined by direct muscle stimulation. J Neurol Neurosurg Psychiatry 2006, 77: 500-506. 10.1136/jnnp.2005.070813PubMedCentralCrossRefPubMed

25.

Lacomis D, Giuliani MJ, Van Cott A, Kramer DJ: Acute myopathy of intensive care: clinical, electromyographic, and pathological aspects. Ann Neurol 1996, 40: 645-654. 10.1002/ana.410400415CrossRefPubMed

26.

Stibler H, Edstrom L, Ahlbeck K, Remahl S, Ansved T: Electrophoretic determination of the myosin/actin ratio in the diagnosis of critical illness myopathy. Intensive Care Med 2003, 29: 1515-1527. 10.1007/s00134-003-1894-9CrossRefPubMed

27.

Guarneri B, Bertolini G, Latronico N: Long-term outcome in patients with critical illness myopathy or neuropathy: the Italian multicentre CRIMYNE study. J Neurol Neurosurg Psychiatry 2008, 79: 838-841. 10.1136/jnnp.2007.142430CrossRefPubMed

28.

Lacomis D, Petrella JT, Giuliani MJ: Causes of neuromuscular weakness in the intensive care unit: a study of ninety-two patients. Muscle Nerve 1998, 21: 610-617. 10.1002/(SICI)1097-4598(199805)21:5<610::AID-MUS7>3.0.CO;2-BCrossRefPubMed

29.

Latronico N, Shehu I, Seghelini E: Neuromuscular sequelae of critical illness. Curr Opin Crit Care 2005, 11: 381-390. 10.1097/01.ccx.0000168530.30702.3eCrossRefPubMed

30.

Hund E: Myopathy in critically ill patients. Crit Care Med 1999, 27: 2544-2547. 10.1097/00003246-199911000-00036CrossRefPubMed

31.

Latronico N, Peli E, Botteri M: Critical illness myopathy and neuropathy. Curr Opin Crit Care 2005, 11: 126-132. 10.1097/01.ccx.0000155357.24360.89CrossRefPubMed

32.

Barohn RJ, Jackson CE, Rogers SJ, Ridings LW, McVey AL: Prolonged paralysis due to nondepolarizing neuromuscular blocking agents and corticosteroids. Muscle Nerve 1994, 17: 647-654. 10.1002/mus.880170613CrossRefPubMed

33.

Bednarik J, Vondracek P, Dusek L, Moravcova E, Cundrle I: Risk factors for critical illness polyneuromyopathy. J Neurol 2005, 252: 343-351. 10.1007/s00415-005-0654-xCrossRefPubMed

34.

de Letter MA, van Doorn PA, Savelkoul HF, Laman JD, Schmitz PI, Op de Coul AA, Visser LH, Kros JM, Teepen JL, Meche FG: Critical illness polyneuropathy and myopathy (CIPNM): evidence for local immune activation by cytokine-expression in the muscle tissue. J Neuroimmunol 2000, 106: 206-213. 10.1016/S0165-5728(99)00252-0CrossRefPubMed

35.

van Mook WN, Hulsewe-Evers RP: Critical illness polyneuropathy. Curr Opin Crit Care 2002, 8: 302-310. 10.1097/00075198-200208000-00006CrossRefPubMed

36.

de Letter MA, Schmitz PI, Visser LH, Verheul FA, Schellens RL, Op de Coul DA, Meche FG: Risk factors for the development of polyneuropathy and myopathy in critically ill patients. Crit Care Med 2001, 29: 2281-2286. 10.1097/00003246-200112000-00008CrossRefPubMed

37.

Stevens RD, Dowdy DW, Michaels RK, Mendez-Tellez PA, Pronovost PJ, Needham DM: Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med 2007, 33: 1876-1891. 10.1007/s00134-007-0772-2CrossRefPubMed

38.

Bercker S, Weber-Carstens S, Deja M, Grimm C, Wolf S, Behse F, Busch T, Falke KJ, Kaisers U: Critical illness polyneuropathy and myopathy in patients with acute respiratory distress syndrome. Crit Care Med 2005, 33: 711-715. 10.1097/01.CCM.0000157969.46388.A2CrossRefPubMed

39.

De Jonghe B, Bastuji-Garin S, Sharshar T, Outin H, Brochard L: Does ICU-acquired paresis lengthen weaning from mechanical ventilation? Intensive Care Med 2004, 30: 1117-1121. 10.1007/s00134-004-2174-zCrossRefPubMed

40.

Leijten FS, de Weerd AW, Poortvliet DC, De Ridder VA, Ulrich C, Harink-De Weerd JE: Critical illness polyneuropathy in multiple organ dysfunction syndrome and weaning from the ventilator. Intensive Care Med 1996, 22: 856-861. 10.1007/BF02044107CrossRefPubMed

41.

Garnacho-Montero J, Amaya-Villar R, Garcia-Garmendia JL, Madrazo-Osuna J, Ortiz-Leyba C: Effect of critical illness polyneuropathy on the withdrawal from mechanical ventilation and the length of stay in septic patients. Crit Care Med 2005, 33: 349-354. 10.1097/01.CCM.0000153521.41848.7ECrossRefPubMed

42.

Leijten FS, Harinck-de Weerd JE, Poortvliet DC, de Weerd AW: The role of polyneuropathy in motor convalescence after prolonged mechanical ventilation. JAMA 1995, 274: 1221-1225. 10.1001/jama.274.15.1221CrossRefPubMed

43.

Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ: Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 2005, 64: 1348-1353.CrossRefPubMed

44.

Hermans G, Wilmer A, Meersseman W, Milants I, Wouters PJ, Bobbaers H, Bruyninckx F, Berghe G: Impact of intensive insulin therapy on neuromuscular complications and ventilator-dependency in MICU. Am J Respir Crit Care Med 2007, 175: 480-489. 10.1164/rccm.200605-665OCCrossRefPubMed

45.

Douglass JA, Tuxen DV, Horne M, Scheinkestel CD, Weinmann M, Czarny D, Bowes G: Myopathy in severe asthma. Am Rev Respir Dis 1992, 146: 517-519.CrossRefPubMed

46.

Campellone JV, Lacomis D, Kramer DJ, Van Cott AC, Giuliani MJ: Acute myopathy after liver transplantation. Neurology 1998, 50: 46-53.CrossRefPubMed

47.

Fletcher SN, Kennedy DD, Ghosh IR, Misra VP, Kiff K, Coakley JH, Hinds CJ: Persistent neuromuscular and neurophysiologic abnormalities in long-term survivors of prolonged critical illness. Crit Care Med 2003, 31: 1012-1016. 10.1097/01.CCM.0000053651.38421.D9CrossRefPubMed

48.

De Jonghe B, Bastuji-Garin S, Durand MC, Malissin I, Rodrigues P, Cerf C, Outin H, Sharshar T: Respiratory weakness is associated with limb weakness and delayed weaning in critical illness. Crit Care Med 2007, 35: 2007-2015. 10.1097/01.ccm.0000281450.01881.d8CrossRefPubMed

49.

Garnacho-Montero J, Madrazo-Osuna J, García-Garmendia JL, Ortiz-Leyba C, Jiménez-Jiménez FJ, Barrero-Almodóvar A, Garnacho-Montero MC, Moyano-Del-Estad MR: Critical illness polyneuropathy: risk factors and clinical consequences. A cohort study in septic patients. Intensive Care Med 2001, 27: 1288-1296. 10.1007/s001340101009CrossRefPubMed

50.

De Jonghe B, Cook D, Sharshar T, Lefaucheur JP, Carlet J, Outin H: Acquired neuromuscular disorders in critically ill patients: a systematic review. Groupe de Reflexion et d'Etude sur les Neuromyopathies En Reanimation. Intensive Care Med 1998, 24: 1242-1250. 10.1007/s001340050757CrossRefPubMed

51.

de Seze M, Petit H, Wiart L, Cardinaud JP, Gaujard E, Joseph PA, Mazaux JM, Barat M: Critical illness polyneuropathy. A 2-year follow-up study in 19 severe cases. Eur Neurol 2000, 43: 61-69.CrossRefPubMed

52.

Kerbaul F, Brousse M, Collart F, Pellissier JF, Planche D, Fernandez C, Gouin F, Guidon C: Combination of histopathological and electromyographic patterns can help to evaluate functional outcome of critical ill patients with neuromuscular weakness syndromes. Crit Care 2004, 8: R358. 10.1186/cc2925PubMedCentralCrossRefPubMed

53.

Herridge MS, Cheung AM, Tansey CM, Matte-Martyn A, Diaz-Granados N, Al Saidi F, Cooper AB, Guest CB, Mazer CD, Mehta S, Stewart TE, Barr A, Cook D, Slutsky AS, Canadian Critical Care Trials Group: One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 2003, 348: 683-693. 10.1056/NEJMoa022450CrossRefPubMed

54.

Schaaf M, Beelen A, de Vos R: Functional outcome in patients with critical illness polyneuropathy. Disabil Rehabil 2004, 26: 1189-1197. 10.1080/09638280410001724861CrossRefPubMed

55.

Dussoix P, Chevrolet JC, Cox J, Pizzolato G, Magistris MR: Secondary neuromyopathies in a resuscitation unit [in French]. Réanimation Urgences 1993, 2: 247-258. 10.1016/S1164-6756(05)80469-4CrossRef

56.

Rivner MH, Kim S, Greenberg M, Swift TR: Reversible generalized paresis following hypertension: a new neurological entity. Neurology 1983, 33: 164.

57.

Wilmshurst PT, Treacher DF, Lantos PL, Wiles CM: Critical illness polyneuropathy following severe hyperpyrexia. QJM 1995, 88: 351-355.PubMed

58.

Mohr M, Englisch L, Roth A, Burchardi H, Zielmann S: Effects of early treatment with immunoglobulin on critical illness polyneuropathy following multiple organ failure and gram-negative sepsis. Intensive Care Med 1997, 23: 1144-1149. 10.1007/s001340050471CrossRefPubMed

59.

Hermans G, De Jonghe B, Bruyninckx F, Berghe G: Interventions for preventing critical illness polyneuropathy and critical illness myopathy. (Protocol). Cochrane Database Syst Rev 2007, (4):CD006832.

60.

Bolton CF: Neuromuscular manifestations of critical illness. Muscle Nerve 2005, 32: 140-163. 10.1002/mus.20304CrossRefPubMed

61.

Fenzi F, Latronico N, Refatti N, Rizzuto N: Enhanced expression of E-selectin on the vascular endothelium of peripheral nerve in critically ill patients with neuromuscular disorders. Acta Neuropathol 2003, 106: 75-82.PubMed

62.

Hund E, Herkert M, Becker CM, Hacke W: A humoral neurotoxic factor in sera of patients with critical illness polyneuropathy. Ann Neurol 1997, 40: 539.

63.

Showalter CJ, Engel AG: Acute quadriplegic myopathy: analysis of myosin isoforms and evidence for calpain-mediated proteolysis. Muscle Nerve 1997, 20: 316-322. 10.1002/(SICI)1097-4598(199703)20:3<316::AID-MUS8>3.0.CO;2-ECrossRefPubMed

64.

Tiao G, Hobler S, Wang JJ, Meyer TA, Luchette FA, Fischer JE, Hasselgren PO: Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle. J Clin Invest 1997, 99: 163-168. 10.1172/JCI119143PubMedCentralCrossRefPubMed

65.

Klaude M, Fredriksson K, Tjader I, Hammarqvist F, Ahlman B, Rooyackers O, Wernerman J: Proteasome proteolytic activity in skeletal muscle is increased in patients with sepsis. Clin Sci (Lond) 2007, 112: 499-506.CrossRef

66.

Di Giovanni S, Mirabella M, D'Amico A, Tonali P, Servidei S: Apoptotic features accompany acute quadriplegic myopathy. Neurology 2000, 55: 854-858.CrossRefPubMed

67.

Wagenmakers AJ: Muscle function in critically ill patients. Clin Nutr 2001, 20: 451-454. 10.1054/clnu.2001.0483CrossRefPubMed

68.

Di Giovanni S, Molon A, Broccolini A, Melcon G, Mirabella M, Hoffman EP, Servidei S: Constitutive activation of MAPK cascade in acute quadriplegic myopathy. Ann Neurol 2004, 55: 195-206. 10.1002/ana.10811CrossRefPubMed

69.

Gamrin L, Andersson K, Hultman E, Nilsson E, Essen P, Wernerman J: Longitudinal changes of biochemical parameters in muscle during critical illness. Metabolism 1997, 46: 756-762. 10.1016/S0026-0495(97)90119-0CrossRefPubMed

70.

Rich MM, Pinter MJ: Crucial role of sodium channel fast inactivation in muscle fibre inexcitability in a rat model of critical illness myopathy. J Physiol 2003, 547: 555-566. 10.1113/jphysiol.2002.035188PubMedCentralCrossRefPubMed

71.

Filatov GN, Rich MM: Hyperpolarized shifts in the voltage dependence of fast inactivation of Nav1.4 and Nav1.5 in a rat model of critical illness myopathy. J Physiol 2004, 559: 813-820.PubMedCentralCrossRefPubMed

72.

Rossignol B, Gueret G, Pennec JP, Morel J, Giroux-Metges MA, Talarmin H, Arvieux CC: Effects of chronic sepsis on the voltage-gated sodium channel in isolated rat muscle fibers. Crit Care Med 2007, 35: 351-357. 10.1097/01.CCM.0000254335.88023.0ECrossRefPubMed

73.

Allen DC, Arunachalam R, Mills KR: Critical illness myopathy: further evidence from muscle-fiber excitability studies of an acquired channelopathy. Muscle Nerve 2008, 37: 14-22. 10.1002/mus.20884CrossRefPubMed

74.

Haeseler G, Foadi N, Wiegand E, Ahrens J, Krampfl K, Dengler R, Leuwer M: Endotoxin reduces availability of voltage-gated human skeletal muscle sodium channels at depolarized membrane potentials. Crit Care Med 2008, 36: 1239-1247.CrossRefPubMed

75.

M Uncini A: Possible role for nitric oxide dysregulation in critical illness myopathy. Muscle Nerve 2008, 37: 196-202. 10.1002/mus.20907CrossRef

76.

Friedrich O, Hund E, Weber C, Hacke W, Fink RH: Critical illness myopathy serum fractions affect membrane excitability and intracellular calcium release in mammalian skeletal muscle. J Neurol 2004, 251: 53-65. 10.1007/s00415-004-0272-zCrossRefPubMed

77.

Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, Davies NA, Cooper CE, Singer M: Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002, 360: 219-223. 10.1016/S0140-6736(02)09459-XCrossRefPubMed

78.

Tiao G, Fagan J, Roegner V, Lieberman M, Wang JJ, Fischer JE, Hasselgren PO: Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids. J Clin Invest 1996, 97: 339-348. 10.1172/JCI118421PubMedCentralCrossRefPubMed

79.

Massa R, Carpenter S, Holland P, Karpati G: Loss and renewal of thick myofilaments in glucocorticoid-treated rat soleus after denervation and reinnervation. Muscle Nerve 1992, 15: 1290-1298. 10.1002/mus.880151112CrossRefPubMed

80.

Z'Graggen WJ, Lin CS, Howard RS, Beale RJ, Bostock H: Nerve excitability changes in critical illness polyneuropathy. Brain 2006, 129: 2461-2470. 10.1093/brain/awl191CrossRefPubMed

81.

Teener JW, Rich MM: Dysregulation of sodium channel gating in critical illness myopathy. J Muscle Res Cell Motil 2006, 27: 291-296. 10.1007/s10974-006-9074-5CrossRefPubMed

82.

Shanely RA, Zergeroglu MA, Lennon SL, Sugiura T, Yimlamai T, Enns D, Belcastro A, Powers SK: Mechanical ventilation-induced diaphragmatic atrophy is associated with oxidative injury and increased proteolytic activity. Am J Respir Crit Care Med 2002, 166: 1369-1374. 10.1164/rccm.200202-088OCCrossRefPubMed

83.

Testelmans D, Maes K, Wouters P, Powers SK, Decramer M, Gayan-Ramirez G: Infusions of rocuronium and cisatracurium exert different effects on rat diaphragm function. Intensive Care Med 2007, 33: 872-879. 10.1007/s00134-007-0584-4CrossRefPubMed

84.

Gayan-Ramirez G, Testelmans D, Maes K, Racz GZ, Cadot P, Zador E, Wuytack F, Decramer M: Intermittent spontaneous breathing protects the rat diaphragm from mechanical ventilation effects. Crit Care Med 2005, 33: 2804-2809. 10.1097/01.CCM.0000191250.32988.A3CrossRefPubMed

85.

Maes K, Testelmans D, Powers S, Decramer M, Gayan-Ramirez G: Leupeptin inhibits ventilator-induced diaphragm dysfunction in rats. Am J Respir Crit Care Med 2007, 175: 1134-1138. 10.1164/rccm.200609-1342OCCrossRefPubMed

86.

Fujimura N, Sumita S, Narimatsu E, Nakayama Y, Shitinohe Y, Namiki A: Effects of isoproterenol on diaphragmatic contractility in septic peritonitis. Am J Respir Crit Care Med 2000, 161: 440-446.CrossRefPubMed

87.

Levine S, Nguyen T, Taylor N, Friscia ME, Budak MT, Rothenberg P, Zhu J, Sachdeva R, Sonnad S, Kaiser LR, Rubinstein NA, Powers SK, Shrager JB: Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med 2008, 358: 1327-1335. 10.1056/NEJMoa070447CrossRefPubMed

88.

Boles JM, Bion J, Connors A, Herridge M, Marsh B, Melot C, Pearl R, Silverman H, Stanchina M, Vieillard-Baron A, Welte T: Weaning from mechanical ventilation. Eur Respir J 2007, 29: 1033-1056. 10.1183/09031936.00010206CrossRefPubMed

89.

Martin UJ, Hincapie L, Nimchuk M, Gaughan J, Criner GJ: Impact of whole-body rehabilitation in patients receiving chronic mechanical ventilation. Crit Care Med 2005, 33: 2259-2265. 10.1097/01.CCM.0000181730.02238.9BCrossRefPubMed

90.

Berard MP, Zazzo JF, Condat P, Vasson MP, Cynober L: Total parenteral nutrition enriched with arginine and glutamate generates glutamine and limits protein catabolism in surgical patients hospitalized in intensive care units. Crit Care Med 2000, 28: 3637-3644. 10.1097/00003246-200011000-00016CrossRefPubMed

91.

Yu YM, Ryan CM, Fei ZW, Lu XM, Castillo L, Schultz JT, Tompkins RG, Young VR: Plasma L-5-oxoproline kinetics and whole blood glutathione synthesis rates in severely burned adult humans. Am J Physiol Endocrinol Metab 2002, 282: E247-E258.CrossRefPubMed

92.

Schols AM, Soeters PB, Mostert R, Pluymers RJ, Wouters EF: Physiologic effects of nutritional support and anabolic steroids in patients with chronic obstructive pulmonary disease. A placebo-controlled randomized trial. Am J Respir Crit Care Med 1995, 152: 1268-1274.CrossRefPubMed

93.

Pichard C, Kyle U, Chevrolet JC, Jolliet P, Slosman D, Mensi N, Temler E, Ricou B: Lack of effects of recombinant growth hormone on muscle function in patients requiring prolonged mechanical ventilation: a prospective, randomized, controlled study. Crit Care Med 1996, 24: 403-413. 10.1097/00003246-199603000-00008CrossRefPubMed

94.

Hansen TK, Thiel S, Wouters PJ, Christiansen JS, Berghe G: Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metab 2003, 88: 1082-1088. 10.1210/jc.2002-021478CrossRefPubMed

95.

Langouche L, Vanhorebeek I, Vlasselaers D, Perre S, Wouters PJ, Skogstrand K, Hansen TK, Berghe G: Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest 2005, 115: 2277-2286. 10.1172/JCI25385PubMedCentralCrossRefPubMed

96.

Ishii DN, Lupien SB: Insulin-like growth factors protect against diabetic neuropathy: effects on sensory nerve regeneration in rats. J Neurosci Res 1995, 40: 138-144. 10.1002/jnr.490400116CrossRefPubMed

97.

Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in the critically ill patients. N Engl J Med 2001, 345: 1359-1367. 10.1056/NEJMoa011300CrossRefPubMed

98.

Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R: Intensive insulin therapy in the medical ICU. N Engl J Med 2006, 354: 449-461. 10.1056/NEJMoa052521CrossRefPubMed

99.

Berghe G, Wilmer A, Milants I, Wouters PJ, Bouckaert B, Bruyninckx F, Bouillon R, Schetz M: Intensive insulin therapy in mixed medical/surgical intensive care units: benefit versus harm. Diabetes 2006, 55: 3151-3159. 10.2337/db06-0855CrossRefPubMed

100.

De Jonghe B, Finfer S: Critical illness neuromyopathy: from risk factors to prevention. Am J Respir Crit Care Med 2007, 175: 424-425. 10.1164/rccm.200612-1762EDCrossRefPubMed

101.

Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y: Corticosteroids for treating severe sepsis and septic shock. Cochrane Database Syst Rev 2004, (1):CD002243.

Title: Clinical review: Critical illness polyneuropathy and myopathy
Authors: Greet Hermans
Bernard De Jonghe
Frans Bruyninckx
Greet Van den Berghe
Publication date: 01-12-2008
Publisher: BioMed Central
Published in: Critical Care / Issue 6/2008
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc7100

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical review: Critical illness polyneuropathy and myopathy

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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