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Critical Care
Published in: Critical Care 6/2008

01-12-2008 | Review

Clinical review: Critical care management of spontaneous intracerebral hemorrhage

Authors: Fred Rincon, Stephan A Mayer

Published in: Critical Care | Issue 6/2008

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Abstract

Intracerebral hemorrhage is by far the most destructive form of stroke. The clinical presentation is characterized by a rapidly deteriorating neurological exam coupled with signs and symptoms of elevated intracranial pressure. The diagnosis is easily established by the use of computed tomography or magnetic resonance imaging. Ventilatory support, blood pressure control, reversal of any preexisting coagulopathy, intracranial pressure monitoring, osmotherapy, fever control, seizure prophylaxis, treatment of hyerglycemia, and nutritional supplementation are the cornerstones of supportive care in the intensive care unit. Dexamethasone and other glucocorticoids should be avoided. Ventricular drainage should be performed urgently in all stuporous or comatose patients with intraventricular blood and acute hydrocephalus. Emergent surgical evacuation or hemicraniectomy should be considered for patients with large (>3 cm) cerebellar hemorrhages, and in those with large lobar hemorrhages, significant mass effect, and a deteriorating neurological exam. Apart from management in a specialized stroke or neurological intensive care unit, no specific medical therapies have been shown to consistently improve outcome after intracerebral hemorrhage.
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Literature
1.
Sacco RL, Mayer SA: Epidemiology of intracerebral hemorrhage. In Intracerebral Hemorrhage. Edited by: Feldmann E. Armonk, NY: Futura Publishing Co; 1994:3-23.
2.
Broderick J, Connolly S, Feldmann E, Hanley D, Kase C, Krieger D, Mayberg M, Morgenstern L, Ogilvy CS, Vespa P, Zuccarello M, American Heart Association; American Stroke Association Stroke Council; High Blood Pressure Research Council; Quality of Care and Outcomes in Research Interdisciplinary Working Group: Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group. Stroke 2007, 38: 2001-2023.PubMed
3.
Gebel JM, Broderick JP: Intracerebral hemorrhage. Neurol Clin 2000, 18: 419-438.PubMed
4.
Holloway RG, Witter DM Jr, Lawton KB, Lipscomb J, Samsa G: Inpatient costs of specific cerebrovascular events at five academic medical centers. Neurology 1996, 46: 854-860.PubMed
5.
Taylor TN, Davis PH, Torner JC, Holmes J, Meyer JW, Jacobson MF: Lifetime cost of stroke in the United States. Stroke 1996, 27: 1459-1466.PubMed
6.
Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF: Spontaneous intracerebral hemorrhage. N Engl J Med 2001, 344: 1450-1460.PubMed
7.
Skidmore CT, Andrefsky J: Spontaneous intracerebral hemorrhage: epidemiology, pathophysiology, and medical management. Neurosurg Clin N Am 2002, 13: 281-288. v.PubMed
8.
Siddique MS, Gregson BA, Fernandes HM, Barnes J, Treadwell L, Wooldridge TD, Mendelow AD: Comparative study of traumatic and spontaneous intracerebral hemorrhage. J Neurosurg 2002, 96: 86-89.PubMed
9.
Mayer SA, Rincon F: Treatment of intracerebral haemorrhage. Lancet Neurol 2005, 4: 662-672.PubMed
10.
Measuring and improving quality of care: a report from the American Heart Association/American College of Cardiology First Scientific Forum on Assessment of Healthcare Quality in Cardiovascular Disease and Stroke Circulation 2000, 101: 1483-1493.
11.
Brott T, Thalinger K, Hertzberg V: Hypertension as a risk factor for spontaneous intracerebral hemorrhage. Stroke 1986, 17: 1078-1083.PubMed
12.
Thrift AG, McNeil JJ, Forbes A, Donnan GA: Three important subgroups of hypertensive persons at greater risk of intracerebral hemorrhage. Melbourne Risk Factor Study Group. Hypertension 1998, 31: 1223-1229.PubMed
13.
Fisher C: Pathological observations in hypertensive intracerebral hemorrhage. J Neuropathol Exp Neurol 1971, 30: 536-550.PubMed
14.
Kase CS, Williams JP, Wyatt DA, Mohr JP: Lobar intracerebral hematomas: clinical and CT analysis of 22 cases. Neurology 1982, 32: 1146-1150.PubMed
15.
Segal AZ, Chiu RI, Eggleston-Sexton PM, Beiser A, Greenberg SM: Low cholesterol as a risk factor for primary intracerebral hemorrhage: A case-control study. Neuroepidemiology 1999, 18: 185-193.PubMed
16.
Iso H, Jacobs DR Jr, Wentworth D, Neaton JD, Cohen JD: Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the multiple risk factor intervention trial. N Engl J Med 1989, 320: 904-910.PubMed
17.
Yano K, Reed DM, MacLean CJ: Serum cholesterol and hemorrhagic stroke in the Honolulu Heart Program. Stroke 1989, 20: 1460-1465.PubMed
18.
Iribarren C, Jacobs DR, Sadler M, Claxton AJ, Sidney S: Low total serum cholesterol and intracerebral hemorrhagic stroke: is the association confined to elderly men? The Kaiser Permanente Medical Care Program. Stroke 1996, 27: 1993-1998.PubMed
19.
Plehn JF, Davis BR, Sacks FM, Rouleau JL, Pfeffer MA, Bernstein V, Cuddy TE, Moyé LA, Piller LB, Rutherford J, Simpson LM, Braunwald E: Reduction of stroke incidence after myocardial infarction with pravastatin: the Cholesterol and Recurrent Events (CARE) study. The Care Investigators. Circulation 1999, 99: 216-223.PubMed
20.
Amarenco P, Bogousslavsky J, Callahan A 3rd, Goldstein LB, Hennerici M, Rudolph AE, Sillesen H, Simunovic L, Szarek M, Welch KM, Zivin JA, Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators: High-dose ator-vastatin after stroke or transient ischemic attack. N Engl J Med 2006, 355: 549-559.PubMed
21.
Gill JS, Shipley MJ, Tsementzis SA, Hornby RS, Gill SK, Hitchcock ER, Beevers DG: Alcohol consumption – a risk factor for hemorrhagic and non-hemorrhagic stroke. Am J Med 1991, 90: 489-497.PubMed
22.
Gill JS, Zezulka AV, Shipley MJ, Gill SK, Beevers DG: Stroke and alcohol consumption. N Engl J Med 1986, 315: 1041-1046.PubMed
23.
24.
Klatsky AL, Armstrong MA, Friedman GD: Alcohol use and subsequent cerebrovascular disease hospitalizations. Stroke 1989, 20: 741-746.PubMed
25.
Thrift AG, Donnan GA, McNeil JJ: Heavy drinking, but not moderate or intermediate drinking, increases the risk of intracerebral hemorrhage. Epidemiology 1999, 10: 307-312.PubMed
26.
Levine SR, Brust JC, Futrell N, Ho KL, Blake D, Millikan CH, Brass LM, Fayad P, Schultz LR, Selwa JF, et al.: Cerebrovascular complications of the use of the "crack" form of alkaloidal cocaine. N Engl J Med 1990, 323: 699-704.PubMed
27.
Ariesen MJ, Claus SP, Rinkel GJ, Algra A: Risk factors for intracerebral hemorrhage in the general population: a systematic review. Stroke 2003, 34: 2060-2065.PubMed
28.
Qureshi AI, Mohammad Y, Suri MF, Braimah J, Janardhan V, Guterman LR, Hopkins LN, Frankel MR: Cocaine use and hypertension are major risk factors for intracerebral hemorrhage in young African Americans. Ethn Dis 2001, 11: 311-319.PubMed
29.
Arboix A, Vall-Llosera A, Garcia-Eroles L, Massons J, Oliveres M, Targa C: Clinical features and functional outcome of intracerebral hemorrhage in patients aged 85 and older. J Am Geriatr Soc 2002, 50: 449-454.PubMed
30.
Daverat P, Castel JP, Dartigues JF, Orgogozo JM: Death and functional outcome after spontaneous intracerebral hemorrhage. A prospective study of 166 cases using multivariate analysis. Stroke 1991, 22: 1-6.PubMed
31.
Broderick JP, Brott T, Tomsick T, Miller R, Huster G: Intracerebral hemorrhage more than twice as common as subarachnoid hemorrhage. J Neurosurg 1993, 78: 188-191.PubMed
32.
Kothari RU, Brott T, Broderick JP, Barsan WG, Sauerbeck LR, Zuccarello M, Khoury J: The ABCs of measuring intracerebral hemorrhage volumes. Stroke 1996, 27: 1304-1305.PubMed
33.
Newman GC: Clarification of abc/2 rule for ICH volume. Stroke 2007, 38: 862.PubMed
34.
Becker KJ, Baxter AB, Bybee HM, Tirschwell DL, Abouelsaad T, Cohen WA: Extravasation of radiographic contrast is an independent predictor of death in primary intracerebral hemorrhage. Stroke 1999, 30: 2025-2032.PubMed
35.
Goldstein JN, Fazen LE, Snider R, Schwab K, Greenberg SM, Smith EE, Lev MH, Rosand J: Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage. Neurology 2007, 68: 889-894.PubMed
36.
Wada R, Aviv RI, Fox AJ, Sahlas DJ, Gladstone DJ, Tomlinson G, Symons SP: CT angiography "spot sign" predicts hematoma expansion in acute intracerebral hemorrhage. Stroke 2007, 38: 1257-1262.PubMed
37.
Kidwell CS, Chalela JA, Saver JL, Starkman S, Hill MD, Demchuk AM, Butman JA, Patronas N, Alger JR, Latour LL, Luby ML, Baird AE, Leary MC, Tremwel M, Ovbiagele B, Fredieu A, Suzuki S, Villablanca JP, Davis S, Dunn B, Todd JW, Ezzeddine MA, Haymore J, Lynch JK, Davis L, Warach S: Comparison of MRI and CT for detection of acute intracerebral hemorrhage. JAMA 2004, 292: 1823-1830.PubMed
38.
Zhu XL, Chan MS, Poon WS: Spontaneous intracranial hemorrhage: which patients need diagnostic cerebral angiography? A prospective study of 206 cases and review of the literature. Stroke 1997, 28: 1406-1409.PubMed
39.
Halpin SF, Britton JA, Byrne JV, Clifton A, Hart G, Moore A: Prospective evaluation of cerebral angiography and computed tomography in cerebral haematoma. J Neurol Neurosurg Psychiatry 1994, 57: 1180-1186.PubMedCentralPubMed
40.
Gujjar AR, Deibert E, Manno EM, Duff S, Diringer MN: Mechanical ventilation for ischemic stroke and intracerebral hemorrhage: indications, timing, and outcome. Neurology 1998, 51: 447-451.PubMed
41.
Diringer MN: Intracerebral hemorrhage: pathophysiology and management. Crit Care Med 1993, 21: 152-157.
42.
Reynolds SF, Heffner J: Airway management of the critically ill patient: rapid-sequence intubation. Chest 2005, 127: 1397-1412.PubMed
43.
Fellows IW, Bastow MD, Byrne AJ, Allison SP: Adrenocortical suppression in multiply injured patients: a complication of etomidate treatment. Br Med J (Clin Res Ed) 1983, 287: 1835-1837.
44.
Papazian L, Albanese J, Thirion X, Perrin G, Durbec O, Martin C: Effect of bolus doses of midazolam on intracranial pressure and cerebral perfusion pressure in patients with severe head injury. Br J Anaesth 1993, 71: 267-271.PubMed
45.
Orebaugh SL: Succinylcholine: adverse effects and alternatives in emergency medicine. Am J Emerg Med 1999, 17: 715-721.PubMed
46.
47.
Schramm WM, Jesenko R, Bartunek A, Gilly H: Effects of cisatracurium on cerebral and cardiovascular hemodynamics in patients with severe brain injury. Acta Anaesthesiol Scand 1997, 41: 1319-1323.PubMed
48.
Schramm WM, Strasser K, Bartunek A, Gilly H, Spiss CK: Effects of rocuronium and vecuronium on intracranial pressure, mean arterial pressure and heart rate in neurosurgical patients. Br J Anaesth 1996, 77: 607-611.PubMed
49.
Robinson N, Clancy M: In patients with head injury undergoing rapid sequence intubation, does pretreatment with intravenous lignocaine/lidocaine lead to an improved neurological outcome? A review of the literature. Emerg Med J 2001, 18: 453-457.PubMedCentralPubMed
50.
Passero S, Ciacci G, Ulivelli M: The influence of diabetes and hyperglycemia on clinical course after intracerebral hemorrhage. Neurology 2003, 61: 1351-1356.PubMed
51.
Siddique MS, Fernandes HM, Wooldridge TD, Fenwick JD, Slomka P, Mendelow AD: Reversible ischemia around intracerebral hemorrhage: a single-photon emission computerized tomography study. J Neurosurg 2002, 96: 736-741.PubMed
52.
Rosand J, Eskey C, Chang Y, Gonzalez RG, Greenberg SM, Koroshetz WJ: Dynamic single-section CT demonstrates reduced cerebral blood flow in acute intracerebral hemorrhage. Cerebrovasc Dis 2002, 14: 214-220.PubMed
53.
Brott T, Broderick J, Kothari R, Barsan W, Tomsick T, Sauerbeck L, Spilker J, Duldner J, Khoury J: Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke 1997, 28: 1-5.PubMed
54.
Broderick JP, Diringer MN, Hill MD, Brun NC, Mayer SA, Steiner T, Skolnick BE, Davis SM: Determinants of intracerebral hemorrhage growth: an exploratory analysis. Stroke 2007, 38: 1072-1075.PubMed
55.
Powers WJ, Zazulia AR, Videen TO, Adams RE, Yundt KD, Aiyagari V, Grubb RL Jr, Diringer MN: Autoregulation of cerebral blood flow surrounding acute (6 to 22 hours) intracerebral hemorrhage. Neurology 2001, 57: 18-24.PubMed
56.
Powers WJ, Adams RE, Yundt KD: Acute pharmacological hypotension after intracerebral hemorrhage does not change cerebral blood flow. Stroke 1999, 30: 242.
57.
Qureshi AI, Wilson DA, Hanley DF, Traystman RJ: Pharmacologic reduction of mean arterial pressure does not adversely affect regional cerebral blood flow and intracranial pressure in experimental intracerebral hemorrhage. Crit Care Med 1999, 27: 965-971.PubMed
58.
Rose JC, Mayer SA: Optimizing blood pressure in neurological emergencies. Neurocritical Care 2004, 1: 287-299.PubMed
59.
Kuwata N, Kuroda K, Funayama M, Sato N, Kubo N, Ogawa A: Dysautoregulation in patients with hypertensive intracerebral hemorrhage. A SPECT study. Neurosurg Rev 1995, 18: 237-245.PubMed
60.
Mayer SA, Lignelli A, Fink ME, Kessler DB, Thomas CE, Swarup R, Van Heertum RL: Perilesional blood flow and edema formation in acute intracerebral hemorrhage: a SPECT study. Stroke 1998, 29: 1791-1798.PubMed
61.
Lang EW, Lagopoulos J, Griffith J, Yip K, Mudaliar Y, Mehdorn HM, Dorsch NW: Noninvasive cerebrovascular autoregulation assessment in traumatic brain injury: validation and utility. J Neurotrauma 2003, 20: 69-75.PubMed
62.
63.
64.
Qureshi AI, Wilson DA, Traystman RJ: Treatment of transtentorial herniation unresponsive to hyperventilation using hypertonic saline in dogs: effect on cerebral blood flow and metabolism. J Neurosurg Anesthesiol 2002, 14: 22-30.PubMed
65.
Poungvarin N, Bhoopat W, Viriyavejakul A, Rodprasert P, Buranasiri P, Sukondhabhant S, Hensley MJ, Strom BL: Effects of dexamethasone in primary supratentorial intracerebral hemorrhage. N Engl J Med 1987, 316: 1229-1233.PubMed
66.
Tellez H, Bauer RB: Dexamethasone as treatment in cerebrovascular disease. 1. A controlled study in intracerebral hemorrhage. Stroke 1973, 4: 541-546.PubMed
67.
Liliang PC, Liang CL, Lu CH, Chang HW, Cheng CH, Lee TC, Chen HJ: Hypertensive caudate hemorrhage prognostic predictor, outcome, and role of external ventricular drainage. Stroke 2001, 32: 1195-1200.PubMed
68.
Fujii Y, Takeuchi S, Sasaki O, Minakawa T, Tanaka R: Multivariate analysis of predictors of hematoma enlargement in spontaneous intracerebral hemorrhage. Stroke 1998, 29: 1160-1166.PubMed
69.
Fujii Y, Tanaka R, Takeuchi S, Koike T, Minakawa T, Sasaki O: Hematoma enlargement in spontaneous intracerebral hemorrhage. J Neurosurg 1994, 80: 51-57.PubMed
70.
Kazui S, Naritomi H, Yamamoto H, Sawada T, Yamaguchi T: Enlargement of spontaneous intracerebral hemorrhage. Incidence and time course. Stroke 1996, 27: 1783-1787.PubMed
71.
Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T: Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 2005, 352: 777-785.PubMed
72.
Piriyawat PML, Yawn DH, Hall CE, Grotta JC: Treatment of Acute Intracerebral Hemorrhage with epsilon aminocaproic Acid: a pilot study. Neurocritical Care 2004, 1: 47-51.PubMed
73.
Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T: Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 2008, 358: 2127-2137.PubMed
74.
Wintzen AR, de Jonge H, Loeliger EA, Bots GT: The risk of intracerebral hemorrhage during oral anticoagulant therapy: a population study. Ann Neurol 1984, 16: 553-558.PubMed
75.
Hart RG, Boop BS, Anderson DC: Oral anticoagulants and intracranial hemorrhage. Facts and hypotheses. Stroke 1995, 26: 1471-1477.PubMed
76.
Fredriksson K, Norrving B, Stromblad LG: Emergency reversal of anticoagulation after intracerebral hemorrhage. Stroke 1992, 23: 972-977.PubMed
77.
Makris M, Greaves M, Phillips WS, Kitchen S, Rosendaal FR, Preston EF: Emergency oral anticoagulant reversal: the relative efficacy of infusions of fresh frozen plasma and clotting factor concentrate on correction of the coagulopathy. Thromb Haemost 1997, 77: 477-480.PubMed
78.
Yasaka M, Sakata T, Minematsu K, Naritomi H: Correction of INR by prothrombin complex concentrate and vitamin K in patients with warfarin related hemorrhagic complication. Thromb Res 2002, 108: 25-30.PubMed
79.
Heit JA: Perioperative management of the chronically anticoagulated patient. J Thromb Thrombolysis 2001, 12: 81-87.PubMed
80.
Sorensen B, Johansen P, Nielsen GL, Sorensen JC, Ingerslev J: Reversal of the International Normalized Ratio with recombinant activated factor VII in central nervous system bleeding during warfarin thromboprophylaxis: clinical and biochemical aspects. Blood Coagul Fibrinolysis 2003, 14: 469-477.PubMed
81.
Erhardtsen E, Nony P, Dechavanne M, Ffrench P, Boissel JP, Hedner U: The effect of recombinant factor VIIa (NovoSeven) in healthy volunteers receiving acenocoumarol to an International Normalized Ratio above 2.0. Blood Coagul Fibrinolysis 1998, 9: 741-748.PubMed
82.
Freeman WD, Brott TG, Barrett KM, Castillo PR, Deen HG Jr, Czervionke LF, Meschia JF: Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhage. Mayo Clin Proc 2004, 79: 1495-1500.PubMed
83.
Wakefield TW, Stanley JC: Intraoperative heparin anticoagulation and its reversal. Semin Vasc Surg 1996, 9: 296-302.PubMed
84.
Mannucci PM, Remuzzi G, Pusineri F, Lombardi R, Valsecchi C, Mecca G, Zimmerman TS: Deamino-8-D-arginine vasopressin shortens the bleeding time in uremia. N Engl J Med 1983, 308: 8-12.PubMed
85.
Ananthasubramaniam K, Beattie JN, Rosman HS, Jayam V, Borzak S: How safely and for how long can warfarin therapy be withheld in prosthetic heart valve patients hospitalized with a major hemorrhage? Chest 2001, 119: 478-484.PubMed
86.
Mayer SA, Sacco RL, Shi T, Mohr JP: Neurologic deterioration in noncomatose patients with supratentorial intracerebral hemorrhage. Neurology 1994, 44: 1379-1384.PubMed
87.
Mayer SA, Chong J: Critical care management of increased intracranial pressure. J Intensive Care Med 2002, 17: 55-67.
88.
Diringer MN, Edwards DF: Admission to a neurologic/neurosurgical intensive care unit is associated with reduced mortality rate after intracerebral hemorrhage. Crit Care Med 2001, 29: 635-640.PubMed
89.
Mirski MA, Chang CW, Cowan R: Impact of a neuroscience intensive care unit on neurosurgical patient outcomes and cost of care: evidence-based support for an intensivist-directed specialty ICU model of care. J Neurosurg Anesthesiol 2001, 13: 83-92.PubMed
90.
Hemphill JC 3rd, Newman J, Zhao S, Johnston SC: Hospital usage of early do-not-resuscitate orders and outcome after intracerebral hemorrhage. Stroke 2004, 35: 1130-1134.PubMed
91.
Becker KJ, Baxter AB, Cohen WA, Bybee HM, Tirschwell DL, Newell DW, Winn HR, Longstreth WT Jr: Withdrawal of support in intracerebral hemorrhage may lead to self-fulfilling prophecies. Neurology 2001, 56: 766-772.PubMed
92.
Ziai WC, Toung TJ, Bhardwaj A: Hypertonic saline: first-line therapy for cerebral edema? J Neurol Sci 2007, 261: 157-166.PubMed
93.
Adrogue HJ, Madias NE: Hypernatremia. N Engl J Med 2000, 342: 1493-1499.PubMed
94.
Broderick JP, Adams HP Jr, Barsan W, Feinberg W, Feldmann E, Grotta J, Kase C, Krieger D, Mayberg M, Tilley B, Zabramski JM, Zuccarello M: Guidelines for the management of spontaneous intracerebral hemorrhage: A statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Stroke 1999, 30: 905-915.PubMed
95.
Passero S, Rocchi R, Rossi S, Ulivelli M, Vatti G: Seizures after spontaneous supratentorial intracerebral hemorrhage. Epilepsia 2002, 43: 1175-1180.PubMed
96.
Vespa PM, O'Phelan K, Shah M, Mirabelli J, Starkman S, Kidwell C, Saver J, Nuwer MR, Frazee JG, McArthur DA, Martin NA: Acute seizures after intracerebral hemorrhage: A factor in progressive midline shift and outcome. Neurology 2003, 60: 1441-1446.PubMed
97.
Claassen J, Jetté N, Chum F, Green R, Schmidt M, Choi H, Jirsch J, Frontera JA, Connolly ES, Emerson RG, Mayer SA, Hirsch LJ: Electrographic seizures and periodic discharges after intracerebral hemorrhage. Neurology 2007, 25: 1356-1365.
98.
Commichau C, Scarmeas N, Mayer SA: Risk factors for fever in the neurologic intensive care unit. Neurology 2003, 60: 837-841.PubMed
99.
Szczudlik A, Turaj W, Slowik A, Strojny J: Hyperthermia is not an independent predictor of greater mortality in patients with primary intracerebral hemorrhage. Med Sci Monit 2002, 8: CR702-707.PubMed
100.
Baena RC, Busto R, Dietrich WD, Globus MY, Ginsberg MD: Hyperthermia delayed by 24 hours aggravates neuronal damage in rat hippocampus following global ischemia. Neurology 1997, 48: 768-773.PubMed
101.
Minamisawa H, Smith ML, Siesjo BK: The effect of mild hyperthermia and hypothermia on brain damage following 5, 10, and 15 minutes of forebrain ischemia. Ann Neurol 1990, 28: 26-33.PubMed
102.
Clasen RA, Pandolfi S, Laing I, Casey D Jr: Experimental study of relation of fever to cerebral edema. J Neurosurg 1974, 41: 576-581.PubMed
103.
Rossi S, Zanier ER, Mauri I, Columbo A, Stocchetti N: Brain temperature, body core temperature, and intracranial pressure in acute cerebral damage. J Neurol Neurosurg Psychiatry 2001, 71: 448-454.PubMedCentralPubMed
104.
Schwab S, Georgiadis D, Berrouschot J, Schellinger PD, Graffagnino C, Mayer SA: Feasibility and safety of moderate hypothermia after massive hemispheric infarction. Stroke 2001, 32: 2033-2035.PubMed
105.
Mayer S, Commichau C, Scarmeas N, Presciutti M, Bates J, Copeland D: Clinical trial of an air-circulating cooling blanket for fever control in critically ill neurologic patients. Neurology 2001, 56: 292-298.PubMed
106.
Diringer MN: Treatment of fever in the neurologic intensive care unit with a catheter-based heat exchange system. Crit Care Med 2004, 32: 559-564.PubMed
107.
Mayer SA, Kowalski RG, Presciutti M, Ostapkovich ND, McGann E, Fitzsimmons BF, Yavagal DR, Du YE, Naidech AM, Janjua NA, Claassen J, Kreiter KT, Parra A, Commichau C: Clinical trial of a novel surface cooling system for fever control in neurocritical care patients. Crit Care Med 2004, 32: 2508-2515.PubMed
108.
Fogelholm R, Murros K, Rissanen A, Avikainen S: Admission blood glucose and short term survival in primary intracerebral haemorrhage: a population based study. J Neurol Neurosurg Psychiatry 2005, 76: 349-353.PubMedCentralPubMed
109.
Baird TA, Parsons MW, Phanh T, Butcher KS, Desmond PM, Tress BM, Colman PG, Chambers BR, Davis SM: Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome. Stroke 2003, 34: 2208-2214.PubMed
110.
Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC: Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 2001, 32: 2426-2432.PubMed
111.
Williams LS, Rotich J, Qi R, Fineberg N, Espay A, Bruno A, Fineberg SE, Tierney WR: Effects of admission hyperglycemia on mortality and costs in acute ischemic stroke. Neurology 2002, 59: 67-71.PubMed
112.
Klip A, Tsakiridis T, Marette A, Ortiz PA: Regulation of expression of glucose transporters by glucose: a review of studies in vivo and in cell cultures. Faseb J 1994, 8: 43-53.PubMed
113.
Berghe G: How does blood glucose control with insulin save lives in intensive care? J Clin Invest 2004, 114: 1187-1195.PubMedCentralPubMed
114.
Langouche L, Berghe G: Glucose metabolism and insulin therapy. Crit Care Clin 2006, 22: 119-129.PubMed
115.
Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ: Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 2005, 64: 1348-1353.PubMed
116.
Nilsson OG, Lindgren A, Brandt L, Saveland H: Prediction of death in patients with primary intracerebral hemorrhage: a prospective study of a defined population. J Neurosurg 2002, 97: 531-536.PubMed
117.
Tuhrim S, Horowitz DR, Sacher M, Godbold JH: Volume of ventricular blood is an important determinant of outcome in supratentorial intracerebral hemorrhage. Crit Care Med 1999, 27: 617-621.PubMed
118.
Bowers SA, Marshall LF: Outcome in 200 consecutive cases of severe head injury treated in San Diego County: a prospective analysis. Neurosurgery 1980, 6: 237-242.PubMed
119.
Unwin DH, Giller CA, Kopitnik TA: Central nervous system monitoring: what helps, what does not. Surg Clin North Am 1991, 71: 733-747.PubMed
120.
Lozier AP, Sciacca RR, Romagnoli MF, Connolly ES Jr: Ventriculostomy-related infections: a critical review of the literature. Neurosurgery 2002, 51: 170-181.PubMed
121.
Adams RE, Diringer MN: Response to external ventricular drainage in spontaneous intracerebral hemorrhage with hydrocephalus. Neurology 1998, 50: 519-523.PubMed
122.
Albanese J, Durbec O, Viviand X, Potie F, Alliez B, Martin C: Sufentanil increases intracranial pressure in patients with head trauma. Anesthesiology 1993, 79: 493-497.PubMed
123.
Kelly DF, Goodale DB, Williams J, Herr DL, Chappell ET, Rosner MJ, Jacobson J, Levy ML, Croce MA, Maniker AH, Fulda GJ, Lovett JV, Mohan O, Narayan RK: Propofol in the treatment of moderate and severe head injury: a randomized, prospective double-blinded pilot trial. J Neurosurg 1999, 90: 1042-1052.PubMed
124.
Kam PC, Cardone D: Propofol infusion syndrome. Anaesthesia 2007, 62: 690-701.PubMed
125.
Lundberg N: Continuous recording and control of ventricular fluid pressure in neurosurgical practice. Acta Psychiatr Scand Suppl 1960, 36: 1-193.PubMed
126.
Chambers IR, Banister K, Mendelow AD: Intracranial pressure within a developing intracerebral haemorrhage. Br J Neurosurg 2001, 15: 140-141.PubMed
127.
Fernandes HM, Siddique S, Banister K, Chambers I, Wooldridge T, Gregson B, Mendelow AD: Continuous monitoring of ICP and CPP following ICH and its relationship to clinical, radiological and surgical parameters. Acta Neurochir Suppl 2000, 76: 463-466.PubMed
128.
Qureshi AI, Suarez JI: Use of hypertonic saline solutions in treatment of cerebral edema and intracranial hypertension. Crit Care Med 2000, 28: 3301-3313.PubMed
129.
Misra UK, Kalita J, Ranjan P, Mandal SK: Mannitol in intracerebral hemorrhage: a randomized controlled study. J Neurol Sci 2005, 234: 41-45.PubMed
130.
Qureshi AI, Geocadin RG, Suarez JI, Ulatowski JA: Long-term outcome after medical reversal of transtentorial herniation in patients with supratentorial mass lesions. Crit Care Med 2000, 28: 1556-1564.PubMed
131.
Shiozaki T, Sugimoto H, Taneda M, Yoshida H, Iwai A, Yoshioka T, Sugimoto T: Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury. J Neurosurg 1993, 79: 363-368.PubMed
132.
Schwab S, Spranger M, Schwarz S, Hacke W: Barbiturate coma in severe hemispheric stroke: useful or obsolete? Neurology 1997, 48: 1608-1613.PubMed
133.
Rincon F, Mayer SA: Therapeutic hypothermia for brain injury after cardiac arrest. Semin Neurol 2006, 26: 387-395.PubMed
134.
Hemphill JC 3rd, Bonovich DC, Besmertis L, Manley GT, Johnston SC: The ICH score: a simple, reliable grading scale for intracerebral hemorrhage. Stroke 2001, 32: 891-897.PubMed
135.
Naff NJ, Carhuapoma JR, Williams MA, Bhardwaj A, Ulatowski JA, Bederson J, Bullock R, Schmutzhard E, Pfausler B, Keyl PM, Tuhrim S, Hanley DF: Treatment of intraventricular hemorrhage with urokinase: effects on 30-day survival. Stroke 2000, 31: 841-847.PubMed
136.
Coplin WM, Vinas FC, Agris JM, Buciuc R, Michael DB, Diaz FG, Muizelaar JP: A cohort study of the safety and feasibility of intraventricular urokinase for nonaneurysmal spontaneous intraventricular hemorrhage. Stroke 1998, 29: 1573-1579.PubMed
137.
Lapointe M, Haines S: Fibrinolytic therapy for intraventricular hemorrhage in adults. Cochrane Database Syst Rev 2002, CD003692.
138.
139.
Nyquist P, Hanley DF: The use of intraventricular thrombolytics in intraventricular hemorrhage. J Neurol Sci 2007, 261: 84-88.PubMed
140.
Geerts WH, Pineo GF, Heit JA, Bergqvist D, Lassen MR, Colwell CW, Ray JG: Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004,126(3 Suppl):338S-400S.PubMed
141.
Boeer A, Voth E, Henze T, Prange HW: Early heparin therapy in patients with spontaneous intracerebral haemorrhage. J Neurol Neurosurg Psychiatry 1991, 54: 466-467.PubMedCentralPubMed
142.
Juvela S, Heiskanen O, Poranen A, Valtonen S, Kuurne T, Kaste M, Troupp H: The treatment of spontaneous intracerebral hemorrhage. A prospective randomized trial of surgical and conservative treatment. J Neurosurg 1989, 70: 755-758.PubMed
143.
Zuccarello M, Brott T, Derex L, Kothari R, Sauerbeck L, Tew J, Van Loveren H, Yeh HS, Tomsick T, Pancioli A, Khoury J, Broderick J: Early surgical treatment for supratentorial intracerebral hemorrhage: a randomized feasibility study. Stroke 1999, 30: 1833-1839.PubMed
144.
Fernandes HM, Gregson B, Siddique S, Mendelow AD: Surgery in intracerebral hemorrhage. The uncertainty continues. Stroke 2000, 31: 2511-2516.PubMed
145.
Mendelow AD, Gregson BA, Fernandes HM, Murray GD, Teasdale GM, Hope DT, Karimi A, Shaw MD, Barer DH: Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial. Lancet 2005, 365: 387-397.PubMed
146.
Bhattathiri PS, Gregson B, Prasad KS, Mendelow AD: Intraventricular hemorrhage and hydrocephalus after spontaneous intracerebral hemorrhage: results from the STICH trial. Acta Neurochir Suppl 2006, 96: 65-68.PubMed
147.
148.
Ott KH, Kase CS, Ojemann RG, Mohr JP: Cerebellar hemorrhage: diagnosis and treatment. A review of 56 cases. Arch Neurol 1974, 31: 160-167.PubMed
149.
Auer LM, Deinsberger W, Niederkorn K, Gell G, Kleinert R, Schneider G, Holzer P, Bone G, Mokry M, Korner E, et al.: Endoscopic surgery versus medical treatment for spontaneous intracerebral hematoma: a randomized study. J Neurosurg 1989, 70: 530-535.PubMed
150.
Teernstra OP, Evers SM, Lodder J, Leffers P, Franke CL, Blaauw G: Stereotactic treatment of intracerebral hematoma by means of a plasminogen activator: a multicenter randomized controlled trial (SICHPA). Stroke 2003, 34: 968-974.PubMed
151.
Murthy JM, Chowdary GV, Murthy TV, Bhasha PS, Naryanan TJ: Decompressive craniectomy with clot evacuation in large hemispheric hypertensive intracerebral hemorrhage. Neurocritical care 2005, 2: 258-262.PubMed
152.
153.
Rincon F, Mayer SA: Novel therapies for intracerebral hemorrhage. Curr Opin Crit Care 2004, 10: 94-100.PubMed
Metadata
Title
Clinical review: Critical care management of spontaneous intracerebral hemorrhage
Authors
Fred Rincon
Stephan A Mayer
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Critical Care / Issue 6/2008
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc7092

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