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Breast Cancer Research
Published in: Breast Cancer Research 4/2008

01-08-2008 | Review

Breast cancer stem cells: implications for therapy of breast cancer

Authors: Brian J Morrison, Chris W Schmidt, Sunil R Lakhani, Brent A Reynolds, J Alejandro Lopez

Published in: Breast Cancer Research | Issue 4/2008

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Abstract

The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatment. Recent improvements in immunotherapy targeting of tumour-associated antigens have advanced the prospect of targeting breast cancer stem cells, an approach that might lead to more meaningful clinical remissions. Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells in disease, and the potential to target these cells.
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Metadata
Title
Breast cancer stem cells: implications for therapy of breast cancer
Authors
Brian J Morrison
Chris W Schmidt
Sunil R Lakhani
Brent A Reynolds
J Alejandro Lopez
Publication date
01-08-2008
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 4/2008
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2111

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