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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2007

01-04-2007 | Review

Cells of the synovium in rheumatoid arthritis. B cells

Authors: Claudia Mauri, Michael R Ehrenstein

Published in: Arthritis Research & Therapy | Issue 2/2007

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Abstract

There is significant evidence arising from experimental models that autoantibodies play a key role in the pathogenesis of inflammatory arthritis. In addition to autoantibody production, B cells efficiently present antigen to T cells, produce soluble factors, including cytokines and chemokines, and form B cell aggregates in the target organ of rheumatoid arthritis. In this review we analyze the multifaceted role that B cells play in the pathogenesis of rheumatoid arthritis and discuss how this information can be used to guide more specific targeting of B cells for the therapy of this disease.
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Metadata
Title
Cells of the synovium in rheumatoid arthritis. B cells
Authors
Claudia Mauri
Michael R Ehrenstein
Publication date
01-04-2007
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2007
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2125

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