Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 5/2000

01-08-2000 | Review

Fibroblast biology Development and differentiation of synovial fibroblasts in arthritis

Author: Jonathan CW Edwards

Published in: Arthritis Research & Therapy | Issue 5/2000

Login to get access

Abstract

Synovial fibroblasts occur as two phenotypes - intimal and subintimal. The specialised intimal phenotype includes expression of uridine diphosphoglucose dehydrogenase (UDPGD), vascular cell adhesion molecule-1 (VCAM-1) and complement decay-accelerating factor (DAF). These gene products contribute to specialised functions relating to tissue movement and leucocyte traffic.
Literature
1.
Edwards JCW: Fibroblast-like synovial lining cells. In Mechanisms and Models in Rheumatoid Arthritis. Edited by Henderson B, Edwards JCW, Pettifer ER. New York: Academic Press. 1995, 153-162.CrossRef
2.
Wilkinson LS, Pitsillides AA, Worrall JG, Edwards JCW: Light microscopic characterisation of the fibroblastic synovial lining cell (synoviocyte). Arthritis Rheum. 1992, 35: 1179-1184.PubMedCrossRef
3.
Medof ME, Walter EI, Rutgers JL, Knowles DM, Nussenzweig V: Identification of the complement decay accelerating factor on epithelium and glandular cells and in body fluids. J Exp Med. 1987, 165: 848-864.PubMedCrossRef
4.
Rice GE, Munro JM, Corless C, Bevilacqua MP: Vascular and non-vascular expression of INCAM-110; a target for mononuclear leucocyte adhesion in normal and inflamed human tissues. Am J Pathol. 1991, 138: 385-393.PubMedPubMedCentral
5.
6.
Dowthwaite GP, Edwards JCW, Pitsillides AA: An essential role for the interaction between hyaluronan and hyaluronan binding proteins during joint development. J Histochem Cytochem. 1998, 46: 641-651.PubMedCrossRef
7.
O'Rahilly R, Gardner E: The embryology of movable joints. In The Joints and Synovial Fluid, vol. 1. Edited by Sokoloff L. New York: Academic Press. 1978, 105-176.
8.
Edwards JCW, Wilkinson LS, Jones HM, Soothill P, Henderson KJ, Worrall JG, Pitsillides AA: The formation of human synovial joint cavities: a possible role for hyaluronan and CD44 in altered inter-zone cohesion. J Anat. 1994, 185: 355-367.PubMedPubMedCentral
9.
Hicok KC, Thomas T, Gori F, Rickard DJ, Spelsberg TC, Riggs BL: Development and characterization of conditionally immortalized osteoblast precursor cell lines from human bone marrow stroma. J Bone Miner Res. 1998, 13: 205-217.PubMedCrossRef
10.
Shimaoka Y, Attrep JF, Hirano T, Ishihara K, Suzuki R, Toyosaki T, Ochi T, Lipsky PE: Nurse-like cells from bone marrow and synovium of patients with rheumatoid arthritis promote survival and enhance function of human B cells. J Clin Invest. 1998, 102: 606-618.PubMedPubMedCentralCrossRef
11.
Edwards JCW, Murray K: Joint development. In Adolescent Rheumatology,Chapter 1. Edited by Isenberg DA, Miller JJ. London: Martin Dunitz. 1999, 1-20.
12.
Yielding KL, Tomkins GM, Bunim JJ: Synthesis of hyaluronic acid by human synovial tissue slices. Science. 1957, 125: 1300-1306.PubMedCrossRef
13.
Revell PA, Al-Saffar N, Fish S, Osei D: Extracellular matrix of the synovial intimal cell layer. Ann RheumDis. 1995, 54: 404-407.CrossRef
14.
Waggett AD, Kielty CM, Shuttleworth CA: Microfibrillar elements in the synovial joint: presence of type VI collagen and fibrillin-containing microfibrils. Ann Rheum Dis. 1993, 52: 449-451.PubMedPubMedCentralCrossRef
15.
16.
Jay GD: Characterization of a bovine synovial fluid lubricating factor. I. Chemical, surface activity and lubricating properties. Connect Tissue Res. 1992, 28: 71-88.PubMedCrossRef
17.
Dobbie JW: Surfactant protein A and lamellar bodies: a homologous secretory function of peritoneum, synovium, and lung. Perit Dial Int. 1996, 16: 574-581.PubMed
18.
El-Gabalawy H, King R, Bernstein C, Ma G, Mou Y, Alguacil-Garcia A, Fritzler M, Wilkins J: Expression of N -acetyl-D-galactosamine associated epitope in synovium: a potential marker of glycoprotein production. J Rheumatol. 1997, 24: 1355-1363.PubMed
19.
Goldring MB, Krane SM: Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultures human cells. J Biol Chem. 1987, 262: 16724-16729.PubMed
20.
Gravallese EM, Darling JM, Ladd AL, Katz JN, Glimcher LH: In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium. Arthritis Rheum. 1991, 34: 1076-1084.PubMedCrossRef
21.
Edwards JCW, Leigh RD, Cambridge G: Expression of molecules involved in B lymphocyte survival and differentiation by synovial fibroblasts. Clin Exp Immunol. 1997, 108: 407-414.PubMedPubMedCentralCrossRef
22.
Bhatia A, Blades S, Cambridge G, Edwards JCW: Differential distribution of Fc γ RIIIa in normal human tissues. Immunology. 1998, 94: 56-63. 10.1046/j.1365-2567.1998.00491.x.PubMedPubMedCentralCrossRef
23.
Hamman J, Vogel B, van Schijndel GMW, van Lier RAW: The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF). J Exp Med. 1996, 184: 1185-1189.CrossRef
24.
Lampert IA, Schofield JB, Amlot P, Van Noorden S: Protection of germinal centres from complement attack. J Pathol. 1993, 170: 115-120.PubMedCrossRef
25.
Finberg RW, White W, Nicholson-Weller A: Decay-accelerating factor expression on either effector or target cells inhibits cytotoxicity by human natural killer cells. J Immunol. 1992, 149: 2055-2060.PubMed
26.
Cumano A, Dieterlen-Lievre F, Godin I: Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura. Cell. 1996, 86: 907-916.PubMedCrossRef
27.
Wilkinson LS, Edwards JCW, Poston R, Haskard DO: Cell populations expressing VCAM-1 in normal and diseased synovium. Lab Invest. 1993, 68: 82-88.PubMed
28.
Hembry RM, Bagga MR, Reynolds JJ, Hamblen DL: Immunolocalisation studies on six matrix metalloproteinases and their inhibitors TIMP-1 and TIMP-2 in synovia from patients with osteo- and rheumatoid arthritis. Ann Rheum Dis. 1995, 54: 25-32.PubMedPubMedCentralCrossRef
29.
Allard SA, Muirden KD, Camplejohn KL, Maini RN: Chondrocyte-derived cells and matrix at the rheumatoid cartilage-pannus junction identified with monoclonal antibodies. Rheumatol Int. 1987, 7: 153-159.PubMedCrossRef
30.
Edwards JCW, Sedgwick AD, Moor AR, Willoughby DA: Degradation of cartilage in contact with soft tissue. Int J Tissue React. 1986, 8: 309-319.PubMed
31.
Seki T, Selby J, Haupl T, Winchester R: Use of differential subtraction methods to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes. Arthritis Rheum. 1998, 41: 1356-1364. 10.1002/1529-0131(199808)41:8<1356::AID-ART4>3.0.CO;2-X.PubMedCrossRef
32.
Fowler MJ, Neff MS, Borghaei RC, Pease EA, Mochan E, Thornton RD: Induction of bone morphogenetic protein-2 by interleukin-1 in human fibroblasts. Biochem Biophys Res Commun. 1998, 248: 450-453. 10.1006/bbrc.1998.8988.PubMedCrossRef
Metadata
Title
Fibroblast biology Development and differentiation of synovial fibroblasts in arthritis
Author
Jonathan CW Edwards
Publication date
01-08-2000
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 5/2000
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar110

Other articles of this Issue 5/2000

Arthritis Research & Therapy 5/2000 Go to the issue

Review

Fibroblast biology Signals targeting the synovial fibroblast in arthritis

Review

Fibroblast biology: Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis

Meeting report

Ninth Asia Pacific League Of Associations For Rheumatology (APLAR) Congress, Beijing, China, 21-26 May, 2000

Research article

The role of X-chromosome inactivation in female predisposition to autoimmunity

Primary research

Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats

Review

Endothelial cells and immune cell migration
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits