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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 5/2000

Open Access 01-08-2000 | Primary research

Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats

Authors: Gisela Segond von Banchet, Peter K Petrow, Rolf Bräuer, Hans-Georg Schaible

Published in: Arthritis Research & Therapy | Issue 5/2000

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Statement of findings

This study describes the upregulation of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion (DRG) neurons in the course of antigen-induced arthritis (AIA) in the rat knee. In the acute phase of AIA, which was characterized by pronounced hyperalgesia, there was a substantial bilateral increase in the proportion of lumbar DRG neurons that express neurokinin 1 receptors (activated by substance P) and bradykinin 2 receptors. In the chronic phase the upregulation of bradykinin 2 receptors persisted on the side of inflammation. The increase in the receptor expression is relevant for the generation of acute and chronic inflammatory pain.
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Metadata
Title
Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats
Authors
Gisela Segond von Banchet
Peter K Petrow
Rolf Bräuer
Hans-Georg Schaible
Publication date
01-08-2000
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 5/2000
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar121

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