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Open Access 01-12-2014 | Commentary

Sarcopenia: burden and challenges for public health

Authors: Charlotte Beaudart, René Rizzoli, Olivier Bruyère, Jean-Yves Reginster, Emmanuel Biver

Published in: Archives of Public Health | Issue 1/2014

Abstract

Sarcopenia, operationally defined as the loss of muscle mass and muscle function, is a major health condition associated with ageing, and contributes to many components of public health at both the patient and the societal levels. Currently, no consensual definition of sarcopenia exists and therefore it is still a challenge to establish the actual prevalence of sarcopenia or to establish the direct and indirect impacts of sarcopenia on public health. Anyway, this geriatric syndrome represents a huge potential public health issue because of its multiple clinical and societal consequences. Moreover, all these aspects have an impact on healthcare costs both for the patient and the society. Therefore, the implementation of effective and broadly applicable preventive and therapeutic interventions has become a medical and societal challenge for the growing number of older persons affected by sarcopenia and its disabling complications.

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Centers for Disease Control and Prevention (CDC): Trends in aging – United States and worldwide. MMWR Morb Mortal Wkly Rep. 2003, 52: 101-104. 106,

Lexell J, Taylor CC, Sjostrom M: What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J Neurol Sci. 1988, 84 (2–3): 275-294.CrossRefPubMed

Rosenberg : Summary comments. Am J Clin Nutr. 1989, 50: 1231-1233.

Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, Garry PJ, Lindeman RD: Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol. 1998, 147 (8): 755-763. 10.1093/oxfordjournals.aje.a009520.CrossRefPubMed

Newman AB, Kupelian V, Visser M, Simonsick E, Goodpaster B, Nevitt M, Kritchevsky SB, Tylavsky FA, Rubin SM, Harris TB: Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc. 2003, 51 (11): 1602-1609. 10.1046/j.1532-5415.2003.51534.x.CrossRefPubMed

Cooper C, Dere W, Evans W, Kanis JA, Rizzoli R, Sayer AA, Sieber CC, Kaufman JM, Abellan Van Kan G, Boonen S, Adachi J, Mitlak B, Tsouderos Y, Rolland Y, Reginster JY: Frailty and sarcopenia: definitions and outcome parameters. Osteoporos Int. 2012, 23 (7): 1839-1848. 10.1007/s00198-012-1913-1.CrossRefPubMed

Muscaritoli M, Anker SD, Argiles J, Aversa Z, Bauer JM, Biolo G, Boirie Y, Bosaeus I, Cederholm T, Costelli P, Fearon KC, Laviano A, Maggio M, Rossi Fanelli F, Schneider SM, Schols A, Sieber CC: Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”. Clin Nutr. 2010, 29 (2): 154-159. 10.1016/j.clnu.2009.12.004.CrossRefPubMed

Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M: Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people. Age Ageing. 2010, 39 (4): 412-423. 10.1093/ageing/afq034.CrossRefPubMedPubMedCentral

Fielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB, Abellan Van Kan G, Andrieu S, Bauer J, Breuille D, Cederholm T, Chandler J, De Meynard C, Donini L, Harris T, Kannt A, Keime Guibert F, Onder G, Papanicolaou D, Rolland Y, Rooks D, Sieber C, Souhami E, Verlaan S, Zamboni M: Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc. 2011, 12 (4): 249-256. 10.1016/j.jamda.2011.01.003.CrossRefPubMed

10.

Morley JE, Abbatecola AM, Argiles JM, Baracos V, Bauer J, Bhasin S, Cederholm T, Coats AJ, Cummings SR, Evans WJ, Fearon K, Ferrucci L, Fielding RA, Guralnik JM, Harris TB, Inui A, Kalantar-Zadeh K, Kirwan BA, Mantovani G, Muscaritoli M, Newman AB, Rossi-Fanelli F, Rosano GM, Roubenoff R, Schambelan M, Sokol GH, Storer TW, Vellas B, von Haehling S, Yeh SS, et al: Sarcopenia with limited mobility: an international consensus. J Am Med Dir Assoc. 2011, 12 (6): 403-409. 10.1016/j.jamda.2011.04.014.CrossRefPubMed

11.

Dam TT, Peters KW, Fragala M, Cawthon PM, Harris TB, McLean R, Shardell M, Alley DE, Kenny A, Ferrucci L, Guralnik J, Kiel DP, Kritchevsky S, Vassileva MT, Studenski S: An evidence-based comparison of operational criteria for the presence of sarcopenia. J Gerontol A Biol Sci Med Sci. 2014, 69 (5): 584-590. 10.1093/gerona/glu013.CrossRefPubMedPubMedCentral

12.

Cooper C, Fielding R, Visser M, Van Loon LJ, Rolland Y, Orwoll E, Reid K, Boonen S, Dere W, Epstein S, Mitlak B, Tsouderos Y, Sayer AA, Rizzoli R, Reginster JY, Kanis JA: Tools in the assessment of sarcopenia. Calcif Tissue Int. 2013, 93 (3): 201-210. 10.1007/s00223-013-9757-z.CrossRefPubMedPubMedCentral

13.

Stevens PJ, Syddall HE, Patel HP, Martin HJ, Cooper C, Aihie Sayer A: Is grip strength a good marker of physical performance among community-dwelling older people?. J Nutr Health Aging. 2012, 16 (9): 769-774. 10.1007/s12603-012-0388-2.CrossRefPubMed

14.

Roberts HC, Denison HJ, Martin HJ, Patel HP, Syddall H, Cooper C, Sayer AA: A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing. 2011, 40 (4): 423-429. 10.1093/ageing/afr051.CrossRefPubMed

15.

Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB: A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994, 49 (2): M85-M94. 10.1093/geronj/49.2.M85.CrossRefPubMed

16.

Studenski SA, Peters KW, Alley DE, Cawthon PM, McLean RR, Harris TB, Ferrucci L, Guralnik JM, Fragala MS, Kenny AM, Kiel DP, Kritchevsky SB, Shardell MD, Dam TT, Vassileva MT: The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci. 2014, 69 (5): 547-558. 10.1093/gerona/glu010.CrossRefPubMedPubMedCentral

17.

Patel HP, Syddall HE, Jameson K, Robinson S, Denison H, Roberts HC, Edwards M, Dennison E, Cooper C, Aihie Sayer A: Prevalence of sarcopenia in community-dwelling older people in the UK using the European working group on sarcopenia in older people (EWGSOP) definition: findings from the Hertfordshire cohort study (HCS). Age Ageing. 2013, 42 (3): 378-384. 10.1093/ageing/afs197.CrossRefPubMedPubMedCentral

18.

Legrand D, Vaes B, Mathei C, Swine C, Degryse JM: The prevalence of sarcopenia in very old individuals according to the European consensus definition: insights from the BELFRAIL study. Age Ageing. 2013, 42 (6): 727-734. 10.1093/ageing/aft128.CrossRefPubMed

19.

Coin A, Sarti S, Ruggiero E, Giannini S, Pedrazzoni M, Minisola S, Rossini M, Del Puente A, Inelmen EM, Manzato E, Sergi G: Prevalence of sarcopenia based on different diagnostic criteria using DEXA and appendicular skeletal muscle mass reference values in an Italian population aged 20 to 80. Am Med Dir Assoc. 2013, 14 (7): 507-512. 10.1016/j.jamda.2013.02.010.CrossRef

20.

Volpato S, Bianchi L, Cherubini A, Landi F, Maggio M, Savino E, Bandinelli S, Ceda GP, Guralnik JM, Zuliani G, Ferrucci L: Prevalence and clinical correlates of sarcopenia in community-dwelling older people: application of the EWGSOP definition and diagnostic algorithm. J Gerontol A Biol Sci Med Sci. 2014, 69 (4): 438-446. 10.1093/gerona/glt149.CrossRefPubMed

21.

Landi F, Cruz-Jentoft AJ, Liperoti R, Russo A, Giovannini S, Tosato M, Capoluongo E, Bernabei R, Onder G: Sarcopenia and mortality risk in frail older persons aged 80 years and older: results from ilSIRENTE study. Age Ageing. 2013, 42 (2): 203-209. 10.1093/ageing/afs194.CrossRefPubMed

22.

Tanimoto Y, Watanabe M, Sun W, Sugiura Y, Tsuda Y, Kimura M, Hayashida I, Kusabiraki T, Kono K: Association between sarcopenia and higher-level functional capacity in daily living in community-dwelling elderly subjects in Japan. Arch Gerontol Geriatr. 2012, 55 (2): e9-e13. 10.1016/j.archger.2012.06.015.CrossRefPubMed

23.

Cruz-Jentoft AJ, Landi F, Schneider SM, Zuniga C, Arai H, Boirie Y, Chen LK, Fielding RA, Martin FC, Michel JP, Sieber C, Stout JR, Studenski SA, Vellas B, Woo J, Zamboni M, Cederholm T: Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the international sarcopenia initiative (EWGSOP and IWGS). Age Ageing. 2014, 0: 1-2.

24.

Batsis JA, Barre LK, Mackenzie TA, Pratt SI, Lopez-Jimenez F, Bartels SJ: Variation in the prevalence of sarcopenia and sarcopenic obesity in older adults associated with different research definitions: dual-energy X-ray absorptiometry data from the national health and nutrition examination survey 1999–2004. J Am Geriatr Soc. 2013, 61 (6): 974-980. 10.1111/jgs.12260.CrossRefPubMed

25.

Bijlsma AY, Meskers CG, Ling CH, Narici M, Kurrle SE, Cameron ID, Westendorp RG, Maier AB: Defining sarcopenia: the impact of different diagnostic criteria on the prevalence of sarcopenia in a large middle aged cohort. Age (Dordr). 2013, 35 (3): 871-881. 10.1007/s11357-012-9384-z.CrossRef

26.

Guralnik JM, Ferrucci L, Pieper CF, Leveille SG, Markides KS, Ostir GV, Studenski S, Berkman LF, Wallace RB: Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol A Biol Sci Med Sci. 2000, 55 (4): M221-M231. 10.1093/gerona/55.4.M221.CrossRefPubMed

27.

Tanimoto Y, Watanabe M, Sun W, Tanimoto K, Shishikura K, Sugiura Y, Kusabiraki T, Kono K: Association of sarcopenia with functional decline in community-dwelling elderly subjects in Japan. Geriatr Gerontol Int. 2013, 13 (4): 958-963. 10.1111/ggi.12037.CrossRefPubMed

28.

Janssen I, Baumgartner RN, Ross R, Rosenberg IH, Roubenoff R: Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. Am J Epidemiol. 2004, 159 (4): 413-421. 10.1093/aje/kwh058.CrossRefPubMed

29.

Reid KF, Naumova EN, Carabello RJ, Phillips EM, Fielding RA: Lower extremity muscle mass predicts functional performance in mobility-limited elders. J Nutr Health Aging. 2008, 12 (7): 493-498. 10.1007/BF02982711.CrossRefPubMedPubMedCentral

30.

Hardy SE, Kang Y, Studenski SA, Degenholtz HB: Ability to walk 1/4 mile predicts subsequent disability, mortality, and health care costs. J Gen Intern Med. 2011, 26 (2): 130-135. 10.1007/s11606-010-1543-2.CrossRefPubMed

31.

Tanimoto Y, Watanabe M, Sun W, Sugiura Y, Hayashida I, Kusabiraki T, Tamaki J: Sarcopenia and falls in community-dwelling elderly subjects in Japan: defining sarcopenia according to criteria of the European working group on sarcopenia in older people. Arch Gerontol Geriatr. 2014, 59 (2): 295-299. 10.1016/j.archger.2014.04.016.CrossRefPubMed

32.

Brotto M, Johnson ML: Endocrine crosstalk between muscle and bone. Curr Osteoporos Rep. 2014, 12 (2): 135-141. 10.1007/s11914-014-0209-0.CrossRefPubMedPubMedCentral

33.

Cianferotti L, Brandi ML: Muscle-bone interactions: basic and clinical aspects. Endocrine. 2014, 45 (2): 165-177. 10.1007/s12020-013-0026-8.CrossRefPubMed

34.

Kim JE, Lee YH, Huh JH, Kang DR, Rhee Y, Lim SK: Early-stage chronic kidney disease, insulin resistance, and osteoporosis as risk factors of sarcopenia in aged population: The Fourth Korea national health and nutrition examination survey (KNHANES IV), 2008–2009. Osteoporos Int. 2014, 2014: 2014-

35.

DiGirolamo DJ, Kiel DP, Esser KA: Bone and skeletal muscle: neighbors with close ties. J Bone Miner Res. 2013, 28 (7): 1509-1518. 10.1002/jbmr.1969.CrossRefPubMedPubMedCentral

36.

Kalyani RR, Corriere M, Ferrucci L: Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases. Lancet Diab Endocrinol. 2014, 2 (10): 819-829. 10.1016/S2213-8587(14)70034-8.CrossRef

37.

Cawthon PM, Fox KM, Gandra SR, Delmonico MJ, Chiou CF, Anthony MS, Sewall A, Goodpaster B, Satterfield S, Cummings SR, Harris TB: Do muscle mass, muscle density, strength, and physical function similarly influence risk of hospitalization in older adults?. J Am Geriatr Soc. 2009, 57 (8): 1411-1419. 10.1111/j.1532-5415.2009.02366.x.CrossRefPubMedPubMedCentral

38.

Vetrano DL, Landi F, Volpato S, Corsonello A, Meloni E, Bernabei R, Onder G: Association of sarcopenia with short- and long-term mortality in older adults admitted to acute care wards: results from the CRIME study. J Gerontol A Biol Sci Med Sci. 2014, 69 (9): 1154-1161. 10.1093/gerona/glu034.CrossRefPubMed

39.

Landi F, Liperoti R, Fusco D, Mastropaolo S, Quattrociocchi D, Proia A, Russo A, Bernabei R, Onder G: Prevalence and risk factors of sarcopenia among nursing home older residents. J Gerontol A Biol Sci Med Sci. 2012, 67 (1): 48-55.CrossRefPubMed

40.

Sheetz KH, Waits SA, Terjimanian MN, Sullivan J, Campbell DA, Wang SC, Englesbe MJ: Cost of major surgery in the sarcopenic patient. J Am Coll Surg. 2013, 217 (5): 813-818. 10.1016/j.jamcollsurg.2013.04.042.CrossRefPubMed

41.

Englesbe MJ, Patel SP, He K, Lynch RJ, Schaubel DE, Harbaugh C, Holcombe SA, Wang SC, Segev DL, Sonnenday CJ: Sarcopenia and mortality after liver transplantation. J Am Coll Surg. 2010, 211 (2): 271-278. 10.1016/j.jamcollsurg.2010.03.039.CrossRefPubMedPubMedCentral

42.

Tan BH, Birdsell LA, Martin L, Baracos VE, Fearon KC: Sarcopenia in an overweight or obese patient is an adverse prognostic factor in pancreatic cancer. Clin Cancer Res. 2009, 15 (22): 6973-6979. 10.1158/1078-0432.CCR-09-1525.CrossRefPubMed

43.

Rizzoli R, Reginster JY, Arnal JF, Bautmans I, Beaudart C, Bischoff-Ferrari H, Biver E, Boonen S, Brandi ML, Chines A, Cooper C, Epstein S, Fielding RA, Goodpaster B, Kanis JA, Kaufman JM, Laslop A, Malafarina V, Mañas LR, Mitlak BH, Oreffo RO, Petermans J, Reid K, Rolland Y, Sayer AA, Tsouderos Y, Visser M, Bruyère O: Quality of life in sarcopenia and frailty. Calcif Tissue Int. 2013, 93 (2): 101-120. 10.1007/s00223-013-9758-y.CrossRefPubMedPubMedCentral

44.

Cooper R, Kuh D, Hardy R: Objectively measured physical capability levels and mortality: systematic review and meta-analysis. BMJ. 2010, 341: c4467-10.1136/bmj.c4467.CrossRefPubMedPubMedCentral

45.

Kimyagarov S, Klid R, Levenkrohn S, Fleissig Y, Kopel B, Arad M, Adunsky A: Body mass index (BMI), body composition and mortality of nursing home elderly residents. Arch Gerontol Geriatr. 2010, 51 (2): 227-230. 10.1016/j.archger.2009.10.013.CrossRefPubMed

46.

Janssen I, Shepard DS, Katzmarzyk PT, Roubenoff R: The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc. 2004, 52 (1): 80-85. 10.1111/j.1532-5415.2004.52014.x.CrossRefPubMed

47.

Gillette-Guyonnet S, Nourhashemi F, Lauque S, Grandjean H, Vellas B: Body composition and osteoporosis in elderly women. Gerontology. 2000, 46 (4): 189-193. 10.1159/000022158.CrossRefPubMed

48.

Baumgartner RN: Body composition in healthy aging. Ann N Y Acad Sci. 2000, 904: 437-448.CrossRefPubMed

49.

Castaneda C, Bermudez OI, Tucker KL: Protein nutritional status and function are associated with type 2 diabetes in Hispanic elders. Am J Clin Nutr. 2000, 72 (1): 89-95.PubMed

50.

Gariballa S, Alessa A: Sarcopenia: prevalence and prognostic significance in hospitalized patients. Clin Nutr. 2013, 32 (5): 772-776. 10.1016/j.clnu.2013.01.010.CrossRefPubMed

51.

Rockwood K, Mitnitski A, Song X, Steen B, Skoog I: Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70. J Am Geriatr Soc. 2006, 54 (6): 975-979. 10.1111/j.1532-5415.2006.00738.x.CrossRefPubMed

52.

Bandeen-Roche K, Xue QL, Ferrucci L, Walston J, Guralnik JM, Chaves P, Zeger SL, Fried LP: Phenotype of frailty: characterization in the women’s health and aging studies. J Gerontol A Biol Sci Med Sci. 2006, 61 (3): 262-266. 10.1093/gerona/61.3.262.CrossRefPubMed

53.

Rothman MD, Leo-Summers L, Gill TM: Prognostic significance of potential frailty criteria. J Am Geriatr Soc. 2008, 56 (12): 2211-2216. 10.1111/j.1532-5415.2008.02008.x.CrossRefPubMedPubMedCentral

54.

Wang SY, Shamliyan TA, Talley KM, Ramakrishnan R, Kane RL: Not just specific diseases: systematic review of the association of geriatric syndromes with hospitalization or nursing home admission. Arch Gerontol Geriatr. 2013, 57 (1): 16-26. 10.1016/j.archger.2013.03.007.CrossRefPubMed

55.

Ray NF, Chan JK, Thamer M, Melton LJ: Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National osteoporosis foundation. J Bone Miner Res. 1997, 12 (1): 24-35. 10.1359/jbmr.1997.12.1.24.CrossRefPubMed

56.

Dodds R, Denison HJ, Ntani G, Cooper R, Cooper C, Sayer AA, Baird J: Birth weight and muscle strength: a systematic review and meta-analysis. J Nutr Health Aging. 2012, 16 (7): 609-615. 10.1007/s12603-012-0053-9.CrossRefPubMed

57.

Robinson SM, Simmonds SJ, Jameson KA, Syddall HE, Dennison EM, Cooper C, Sayer AA: Muscle strength in older community-dwelling men is related to type of milk feeding in infancy. J Gerontol A Biol Sci Med Sci. 2012, 67 (9): 990-996. 10.1093/gerona/gls061.CrossRefPubMed

58.

Sayer AA, Robinson SM, Patel HP, Shavlakadze T, Cooper C, Grounds MD: New horizons in the pathogenesis, diagnosis and management of sarcopenia. Age Ageing. 2013, 42 (2): 145-150. 10.1093/ageing/afs191.CrossRefPubMedPubMedCentral

59.

White TA, Lebrasseur NK: Myostatin and sarcopenia: opportunities and challenges - a mini-review. Gerontology. 2014, 60 (4): 289-293. 10.1159/000356740.CrossRefPubMed

60.

Morley JE, Von Haehling S, Anker SD: Are we closer to having drugs to treat muscle wasting disease?. J Cachexia Sarcopenia Muscle. 2014, 5 (2): 83-87. 10.1007/s13539-014-0149-7.CrossRefPubMedPubMedCentral

Title: Sarcopenia: burden and challenges for public health
Authors: Charlotte Beaudart
René Rizzoli
Olivier Bruyère
Jean-Yves Reginster
Emmanuel Biver
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Archives of Public Health / Issue 1/2014
Electronic ISSN: 2049-3258
DOI: https://doi.org/10.1186/2049-3258-72-45

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