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Calcified Tissue International
Published in: Calcified Tissue International 2/2013

01-08-2013 | Review

Quality of Life in Sarcopenia and Frailty

Authors: René Rizzoli, Jean-Yves Reginster, Jean-François Arnal, Ivan Bautmans, Charlotte Beaudart, Heike Bischoff-Ferrari, Emmanuel Biver, Steven Boonen, Maria-Luisa Brandi, Arkadi Chines, Cyrus Cooper, Sol Epstein, Roger A. Fielding, Bret Goodpaster, John A. Kanis, Jean-Marc Kaufman, Andrea Laslop, Vincenzo Malafarina, Leocadio Rodriguez Mañas, Bruce H. Mitlak, Richard O. Oreffo, Jean Petermans, Kieran Reid, Yves Rolland, Avan Aihie Sayer, Yannis Tsouderos, Marjolein Visser, Olivier Bruyère

Published in: Calcified Tissue International | Issue 2/2013

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Abstract

The reduced muscle mass and impaired muscle performance that define sarcopenia in older individuals are associated with increased risk of physical limitation and a variety of chronic diseases. They may also contribute to clinical frailty. A gradual erosion of quality of life (QoL) has been evidenced in these individuals, although much of this research has been done using generic QoL instruments, particularly the SF-36, which may not be ideal in older populations with significant comorbidities. This review and report of an expert meeting presents the current definitions of these geriatric syndromes (sarcopenia and frailty). It then briefly summarizes QoL concepts and specificities in older populations and examines the relevant domains of QoL and what is known concerning QoL decline with these conditions. It calls for a clearer definition of the construct of disability, argues that a disease-specific QoL instrument for sarcopenia/frailty would be an asset for future research, and discusses whether there are available and validated components that could be used to this end and whether the psychometric properties of these instruments are sufficiently tested. It calls also for an approach using utility weighting to provide some cost estimates and suggests that a time trade-off study could be appropriate.
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Metadata
Title
Quality of Life in Sarcopenia and Frailty
Authors
René Rizzoli
Jean-Yves Reginster
Jean-François Arnal
Ivan Bautmans
Charlotte Beaudart
Heike Bischoff-Ferrari
Emmanuel Biver
Steven Boonen
Maria-Luisa Brandi
Arkadi Chines
Cyrus Cooper
Sol Epstein
Roger A. Fielding
Bret Goodpaster
John A. Kanis
Jean-Marc Kaufman
Andrea Laslop
Vincenzo Malafarina
Leocadio Rodriguez Mañas
Bruce H. Mitlak
Richard O. Oreffo
Jean Petermans
Kieran Reid
Yves Rolland
Avan Aihie Sayer
Yannis Tsouderos
Marjolein Visser
Olivier Bruyère
Publication date
01-08-2013
Publisher
Springer US
Published in
Calcified Tissue International / Issue 2/2013
Print ISSN: 0171-967X
Electronic ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-013-9758-y

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