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Open Access 01-12-2011 | Research

CRP gene variation affects early development of Alzheimer's disease-related plaques

Authors: Eloise Helena Kok, Mervi Alanne-Kinnunen, Karita Isotalo, Teemu Luoto, Satu Haikonen, Sirkka Goebeler, Markus Perola, Mikko A Hurme, Hannu Haapasalo, Pekka J Karhunen

Published in: Journal of Neuroinflammation | Issue 1/2011

Abstract

Introduction

We used the Tampere Autopsy Study (TASTY) series (n = 603, age 0-97 yrs), representing an unselected population outside institutions, to investigate the pathogenic involvement of inflammation in Alzheimer's disease-related lesions.

Methods

We studied senile plaque (SP), neurofibrillary tangles (NFT) and SP phenotype associations with 6 reported haplotype tagging single nucleotide polymorphisms (SNPs) in the CRP gene. CRP and Aβ immunohistochemistry was assessed using brain tissue microarrays.

Results

In multivariate analyses (age- and APOE-adjusted), non-neuritic SP were associated with the high-CRP TA-genotype (3.0% prevalence) of rs3091244 and CA-genotype (10.8%) of rs3093075 compared to common genotypes. Conversely, the low-CRP C allele (39.3%) of rs2794521 reduced the risk of harbouring early non-neuritic SP, compared to the TT genotype. CRP haplotype TAGCC (high) associated with non-neuritic SP, whereas haplotype CCGCC offered protection. TT genotypes (high) of rs3091244 and rs1130864 were associated with CRP staining. There were no associations between SNPs or haplotypes and NFT. CRP staining of the hippocampal CA1/2 region correlated with Aβ staining.

Conclusions

CRP gene variation affects early SP development in prodromal Alzheimer's disease, independent of APOE genotype.

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Title: CRP gene variation affects early development of Alzheimer's disease-related plaques
Authors: Eloise Helena Kok
Mervi Alanne-Kinnunen
Karita Isotalo
Teemu Luoto
Satu Haikonen
Sirkka Goebeler
Markus Perola
Mikko A Hurme
Hannu Haapasalo
Pekka J Karhunen
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Journal of Neuroinflammation / Issue 1/2011
Electronic ISSN: 1742-2094
DOI: https://doi.org/10.1186/1742-2094-8-96

Keynote webinar | Spotlight on medication adherence

Springer Medicine

CRP gene variation affects early development of Alzheimer's disease-related plaques

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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