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Open Access 01-12-2006 | Case report

Dedifferentiated chondrosarcoma with leukocytosis and elevation of serum G-CSF. A case report

Authors: Akio Sakamoto, Hidetaka Yamamoto, Kazuhiro Tanaka, Shuichi Matsuda, Katsumi Harimaya, Yoshinao Oda, Masazumi Tsuneyoshi, Yukihide Iwamoto

Published in: World Journal of Surgical Oncology | Issue 1/2006

Abstract

Background

G-CSF is known to function as a hematopoietic growth factor and it is known to be responsible for leukocytosis. G-CSF-producing tumors associated with leukocytosis include various types of malignancies.

Case presentation

We report the case of a 72-year-old man with dedifferentiated chondrosarcoma characterized by dedifferentiated components of malignant fibrous histiocytoma- or osteosarcoma-like features in addition to conventional chondrosarcoma, arising from his pelvic bone. After hemipelvectomy, when local recurrence and metastasis were identified, leukocytosis appeared and an elevated level of serum granulocyte-colony-stimulating factor (G-CSF) was also recognized. The patient died of multiple organ failure 2 months after surgery. Autopsy specimens showed that the histological specimens of the recurrence and metastasis were dedifferentiated components, without any conventional chondrosarcoma components. G-CSF was expressed only in the dedifferentiated components, not in the chondrosarcoma components, immunohistochemically.

Conclusion

This is the first report of chondrosarcoma, or any other primary bone tumor, with leukocytosis, probably stimulated by tumor-produced G-CSF from the dedifferentiated components.

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Title: Dedifferentiated chondrosarcoma with leukocytosis and elevation of serum G-CSF. A case report
Authors: Akio Sakamoto
Hidetaka Yamamoto
Kazuhiro Tanaka
Shuichi Matsuda
Katsumi Harimaya
Yoshinao Oda
Masazumi Tsuneyoshi
Yukihide Iwamoto
Publication date: 01-12-2006
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2006
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-4-37

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Dedifferentiated chondrosarcoma with leukocytosis and elevation of serum G-CSF. A case report

Abstract

Background

Case presentation

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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