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Published in: Health and Quality of Life Outcomes 1/2008

Open Access 01-12-2008 | Research

What determines subjective health status in patients with chronic obstructive pulmonary disease: importance of symptoms in subjective health status of COPD patients

Authors: Signe Berit Bentsen, Anne Hildur Henriksen, Tore Wentzel-Larsen, Berit Rokne Hanestad, Astrid Klopstad Wahl

Published in: Health and Quality of Life Outcomes | Issue 1/2008

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Abstract

Background

Subjective health status is the result of an interaction between physiological and psychosocial factors in patients with chronic obstructive pulmonary disease (COPD). However, there is little understanding of multivariate explanations of subjective health status in COPD. The purpose of this study was to explore what determines subjective health status in COPD by evaluating the relationships between background variables such as age and sex, predicted FEV1%, oxygen saturation, breathlessness, anxiety and depression, exercise capacity, and physical and mental health.

Methods

This study had a cross-sectional design, and included 100 COPD patients (51% men, mean age 66.1 years). Lung function was assessed by predicted FEV1%, oxygen saturation by transcutaneous pulse oximeter, symptoms with the St George Respiratory Questionnaire and the Hospital Anxiety and Depression Scale, physical function with the Incremental Shuttle Walking Test, and subjective health status with the SF-36 health survey. Linear regression analysis was used.

Results

Older patients reported less breathlessness and women reported more anxiety (p < 0.050). Women, older patients, those with lower predicted FEV1%, and those with greater depression had lower physical function (p < 0.050). Patients with higher predicted FEV1%, those with more breathlessness, and those with more anxiety or depression reported lower subjective health status (p < 0.050). Symptoms explained the greatest variance in subjective health status (35%–51%).

Conclusion

Symptoms are more important for the subjective health status of patients with COPD than demographics, physiological variables, or physical function. These findings should be considered in the treatment and care of these patients.
Appendix
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Literature
1.
go back to reference GOLD: Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. GOLD Science Committee. Oregon, Global initiative for chronic Obstructive Lung Disease; 2007:1–89. GOLD: Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. GOLD Science Committee. Oregon, Global initiative for chronic Obstructive Lung Disease; 2007:1–89.
2.
go back to reference Hoogendoorn M, Rutten-van Mölken MP, Hoogenveen RT, van Genugten ML, Buist AS, Wouters EF, Feenstra TL: A dynamic population model of disease progression in COPD. Eur Respir J 2005, 26: 223–233. 10.1183/09031936.05.00122004CrossRefPubMed Hoogendoorn M, Rutten-van Mölken MP, Hoogenveen RT, van Genugten ML, Buist AS, Wouters EF, Feenstra TL: A dynamic population model of disease progression in COPD. Eur Respir J 2005, 26: 223–233. 10.1183/09031936.05.00122004CrossRefPubMed
3.
go back to reference Reardon JZ, Lareau SC, Zuwallack R: Functional status and quality of life in chronic pulmonary disease. Am J Med 2006, 119: 532–537. 10.1016/j.amjmed.2006.08.005CrossRef Reardon JZ, Lareau SC, Zuwallack R: Functional status and quality of life in chronic pulmonary disease. Am J Med 2006, 119: 532–537. 10.1016/j.amjmed.2006.08.005CrossRef
4.
go back to reference Wilson IB, Cleary PD: Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. JAMA 1995, 273: 59–65. 10.1001/jama.273.1.59CrossRefPubMed Wilson IB, Cleary PD: Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. JAMA 1995, 273: 59–65. 10.1001/jama.273.1.59CrossRefPubMed
5.
go back to reference De Torres JP, Casanova C, Hernàndez C, Abereu J, Aguirre-Jaime A, Celli BR: Gender and COPD in patients attending a pulmonary clinic. Chest 2005, 128: 2012–2016. 10.1378/chest.128.4.2012CrossRefPubMed De Torres JP, Casanova C, Hernàndez C, Abereu J, Aguirre-Jaime A, Celli BR: Gender and COPD in patients attending a pulmonary clinic. Chest 2005, 128: 2012–2016. 10.1378/chest.128.4.2012CrossRefPubMed
6.
go back to reference Anderson KL: The effect of chronic obstructive pulmonary disease on quality of life. Res Nurs Health 1995, 18: 547–556. 10.1002/nur.4770180610CrossRefPubMed Anderson KL: The effect of chronic obstructive pulmonary disease on quality of life. Res Nurs Health 1995, 18: 547–556. 10.1002/nur.4770180610CrossRefPubMed
7.
go back to reference Stavem K, Erikssen J, Boe J: Health-related quality of life is associated with arterial PO2in chronic obstructive pulmonary disease. Respir Med 2000, 94: 772–777. 10.1053/rmed.2000.0821CrossRefPubMed Stavem K, Erikssen J, Boe J: Health-related quality of life is associated with arterial PO2in chronic obstructive pulmonary disease. Respir Med 2000, 94: 772–777. 10.1053/rmed.2000.0821CrossRefPubMed
8.
go back to reference Cleland JA, Lee AJ, Hall S: Associations of depression and anxiety with gender, age, health-related quality of life and symptoms in primary care COPD patients. Family Practice 2007, 24: 217–223. 10.1093/fampra/cmm009CrossRefPubMed Cleland JA, Lee AJ, Hall S: Associations of depression and anxiety with gender, age, health-related quality of life and symptoms in primary care COPD patients. Family Practice 2007, 24: 217–223. 10.1093/fampra/cmm009CrossRefPubMed
9.
go back to reference Rejeski JW, Foley KO, Woodard M, Zaccaro DJ, Berry MJ: Evaluating and understanding performance testing in COPD patients. J Cardiopulm Rehabil 2000, 20: 79–88. 10.1097/00008483-200003000-00001CrossRefPubMed Rejeski JW, Foley KO, Woodard M, Zaccaro DJ, Berry MJ: Evaluating and understanding performance testing in COPD patients. J Cardiopulm Rehabil 2000, 20: 79–88. 10.1097/00008483-200003000-00001CrossRefPubMed
10.
go back to reference van Manen JG, Bindels PJE, Dekker FW, Bottema BJ, Zee JS, Ijzermans CJ, Schadé E: The influence of COPD on health-related quality of life independent of the influence of comorbidity. J Clin Epidemiol 2003, 56: 1177–1184. 10.1016/S0895-4356(03)00208-7CrossRefPubMed van Manen JG, Bindels PJE, Dekker FW, Bottema BJ, Zee JS, Ijzermans CJ, Schadé E: The influence of COPD on health-related quality of life independent of the influence of comorbidity. J Clin Epidemiol 2003, 56: 1177–1184. 10.1016/S0895-4356(03)00208-7CrossRefPubMed
11.
go back to reference Haave E, Hyland ME, Engvik H: Improvements in exercise capacity during a 4-weeks pulmonary rehabilitation program for COPD patients do not correspond with improvements in self-reported health status or quality of life. Int J Chron Obstruct Pulmon Dis 2007, 2: 355–359.PubMedCentralPubMed Haave E, Hyland ME, Engvik H: Improvements in exercise capacity during a 4-weeks pulmonary rehabilitation program for COPD patients do not correspond with improvements in self-reported health status or quality of life. Int J Chron Obstruct Pulmon Dis 2007, 2: 355–359.PubMedCentralPubMed
12.
go back to reference Katsura H, Yamada K, Kida K: Both generic and disease specific health-related quality of life are deteriorated in patients with underweight COPD. Respir Med 2005, 99: 624–630. 10.1016/j.rmed.2004.09.017CrossRefPubMed Katsura H, Yamada K, Kida K: Both generic and disease specific health-related quality of life are deteriorated in patients with underweight COPD. Respir Med 2005, 99: 624–630. 10.1016/j.rmed.2004.09.017CrossRefPubMed
13.
go back to reference Hynninen KMJ, Pallesen P, Nordhus IH: Factors affecting health status in COPD patients with co-morbid anxiety and depression. Int J Chron Obstruct Pulmon Dis 2007, 2: 323–328.PubMedCentralPubMed Hynninen KMJ, Pallesen P, Nordhus IH: Factors affecting health status in COPD patients with co-morbid anxiety and depression. Int J Chron Obstruct Pulmon Dis 2007, 2: 323–328.PubMedCentralPubMed
14.
go back to reference Engel GL: The need for a new medical model: a challenge for biomedicine. Science 1977, 196: 129–136. 10.1126/science.847460CrossRefPubMed Engel GL: The need for a new medical model: a challenge for biomedicine. Science 1977, 196: 129–136. 10.1126/science.847460CrossRefPubMed
15.
go back to reference Quanjer PH, Tammeling JE, Cotes JE, Pedersen OF, Peslin R, Yernault JC: Lung volumes and forced ventilatory flows. Report working party standardization of lung function tests, European Community for Steel and Coal. Official statement of the European Respiratory Society. Eur Respir J Suppl 1993, 16: 5–40.CrossRefPubMed Quanjer PH, Tammeling JE, Cotes JE, Pedersen OF, Peslin R, Yernault JC: Lung volumes and forced ventilatory flows. Report working party standardization of lung function tests, European Community for Steel and Coal. Official statement of the European Respiratory Society. Eur Respir J Suppl 1993, 16: 5–40.CrossRefPubMed
16.
go back to reference Gulsvik A, Tosteson T, Bakke PS, Humerfelt S, Weiss ST, Speizer FE: Expiratory and inspiratory forced vital capacity and one-second forced volume in asymptomatic never-smokers in Norway. Clin Physiol 2001, 21: 648–660. 10.1046/j.1365-2281.2001.00377.xCrossRefPubMed Gulsvik A, Tosteson T, Bakke PS, Humerfelt S, Weiss ST, Speizer FE: Expiratory and inspiratory forced vital capacity and one-second forced volume in asymptomatic never-smokers in Norway. Clin Physiol 2001, 21: 648–660. 10.1046/j.1365-2281.2001.00377.xCrossRefPubMed
17.
go back to reference Würtemberger G, Müller S, Matthys H, Sokolov I: Accuracy of nine commercially available pulse oximeters in monitoring patients with chronic respiratory insufficiency. Monaldi Arch Chest Dis 1994, 49: 348–353.PubMed Würtemberger G, Müller S, Matthys H, Sokolov I: Accuracy of nine commercially available pulse oximeters in monitoring patients with chronic respiratory insufficiency. Monaldi Arch Chest Dis 1994, 49: 348–353.PubMed
18.
go back to reference Bausewein C, Farquhar M, Booth S, Gysels M, Higginson IJ: Measurement of breathlessness in advanced disease: A systematic review. Respiratory Medicine 2007, 101: 399–410. 10.1016/j.rmed.2006.07.003CrossRefPubMed Bausewein C, Farquhar M, Booth S, Gysels M, Higginson IJ: Measurement of breathlessness in advanced disease: A systematic review. Respiratory Medicine 2007, 101: 399–410. 10.1016/j.rmed.2006.07.003CrossRefPubMed
19.
go back to reference Jones NM, Quirk FH, Baveystock CM: The St George's Respiratory Questionnaire. Respir Med 1991, 85: 25–35. 10.1016/S0954-6111(06)80166-6CrossRefPubMed Jones NM, Quirk FH, Baveystock CM: The St George's Respiratory Questionnaire. Respir Med 1991, 85: 25–35. 10.1016/S0954-6111(06)80166-6CrossRefPubMed
20.
go back to reference Jones PW, Quirk FH, Baveystock CM, Littlejohns P: A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire. Am Rev Respir Dis 1992, 145: 1321–1327.CrossRefPubMed Jones PW, Quirk FH, Baveystock CM, Littlejohns P: A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire. Am Rev Respir Dis 1992, 145: 1321–1327.CrossRefPubMed
21.
go back to reference Jones PW, Spencer S, Adie S: The St George's Respiratory Questionnaire Manual. London: Respiratory Medicine, St. George's Hospital Medical School; 2003. Jones PW, Spencer S, Adie S: The St George's Respiratory Questionnaire Manual. London: Respiratory Medicine, St. George's Hospital Medical School; 2003.
22.
go back to reference Andenæs R, Kalfoss MH, Wahl A: Psychological distress and quality of life in hospitalized patients with chronic obstructive pulmonary disease. J Adv Nurs 2004, 46: 523–530. 10.1111/j.1365-2648.2004.03026.xCrossRefPubMed Andenæs R, Kalfoss MH, Wahl A: Psychological distress and quality of life in hospitalized patients with chronic obstructive pulmonary disease. J Adv Nurs 2004, 46: 523–530. 10.1111/j.1365-2648.2004.03026.xCrossRefPubMed
23.
go back to reference Gallefoss F, Bakke PS, Kjærsgaard P: Quality of life assessment after patient education in a randomized controlled study on asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999, 159: 812–817.CrossRefPubMed Gallefoss F, Bakke PS, Kjærsgaard P: Quality of life assessment after patient education in a randomized controlled study on asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999, 159: 812–817.CrossRefPubMed
24.
go back to reference Barr JT, Schumacher GE, Freeman S, Lemoine M, Bakst AW, Jones PW: American translation, and validation of the St. George's Respiratory Questionnaire. Clin Ther 2000, 22: 1121–1145. 10.1016/S0149-2918(00)80089-2CrossRefPubMed Barr JT, Schumacher GE, Freeman S, Lemoine M, Bakst AW, Jones PW: American translation, and validation of the St. George's Respiratory Questionnaire. Clin Ther 2000, 22: 1121–1145. 10.1016/S0149-2918(00)80089-2CrossRefPubMed
25.
go back to reference Engström CP, Persson LO, Larsson S, Sullivan M: Reliability and validity of Swedish version of the St George's Respiratory Questionnaire. Eur Respir J 1998, 11: 61–66. 10.1183/09031936.98.11010061CrossRefPubMed Engström CP, Persson LO, Larsson S, Sullivan M: Reliability and validity of Swedish version of the St George's Respiratory Questionnaire. Eur Respir J 1998, 11: 61–66. 10.1183/09031936.98.11010061CrossRefPubMed
26.
go back to reference Mölken MR, Roos B, Van Noord JA: An empirical comparison of the St George's Respiratory Questionnaire (SGRQ) and the Chronic Respiratory Disease Questionnaire (CRQ) in a clinical trial setting. Thorax 1999, 54: 995–1003.PubMedCentralCrossRef Mölken MR, Roos B, Van Noord JA: An empirical comparison of the St George's Respiratory Questionnaire (SGRQ) and the Chronic Respiratory Disease Questionnaire (CRQ) in a clinical trial setting. Thorax 1999, 54: 995–1003.PubMedCentralCrossRef
27.
go back to reference Snaith RP, Zigmond AS: The Hospital Anxiety and Depression Scale Manual. London: NFRF-Nelson Publishing Company Ltd; 1994. Snaith RP, Zigmond AS: The Hospital Anxiety and Depression Scale Manual. London: NFRF-Nelson Publishing Company Ltd; 1994.
28.
go back to reference Zigmond AS, Snaith RP: The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand 1983, 67: 361–370. 10.1111/j.1600-0447.1983.tb09716.xCrossRefPubMed Zigmond AS, Snaith RP: The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand 1983, 67: 361–370. 10.1111/j.1600-0447.1983.tb09716.xCrossRefPubMed
29.
go back to reference Bjelland I, Dahl AA, Haug TT, Necklemann D: The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res 2002, 52: 69–77. 10.1016/S0022-3999(01)00296-3CrossRefPubMed Bjelland I, Dahl AA, Haug TT, Necklemann D: The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res 2002, 52: 69–77. 10.1016/S0022-3999(01)00296-3CrossRefPubMed
30.
go back to reference Olssøn I, Mykletun A, Dahl AA: The hospital anxiety and depression rating scale: A cross-sectional study of psychometrics and case finding abilities in general practice. BMC Psychiatry 2006, 5: 46. 10.1186/1471-244X-5-46CrossRef Olssøn I, Mykletun A, Dahl AA: The hospital anxiety and depression rating scale: A cross-sectional study of psychometrics and case finding abilities in general practice. BMC Psychiatry 2006, 5: 46. 10.1186/1471-244X-5-46CrossRef
31.
go back to reference Nortvedt MW, Riise T, Sanne B: Are men more depressed than women in Norway? Validity of the Hospital Anxiety and Depression Scale. J Psychosom Res 2006, 60: 195–198. 10.1016/j.jpsychores.2005.07.002CrossRefPubMed Nortvedt MW, Riise T, Sanne B: Are men more depressed than women in Norway? Validity of the Hospital Anxiety and Depression Scale. J Psychosom Res 2006, 60: 195–198. 10.1016/j.jpsychores.2005.07.002CrossRefPubMed
32.
go back to reference Schanning CG: Evaluering av rehabiliteringskurs for pasienter med kronisk obstruktiv lungesykdom. Tidsskr Nor Laegeforen 2000, 120: 551–555. Schanning CG: Evaluering av rehabiliteringskurs for pasienter med kronisk obstruktiv lungesykdom. Tidsskr Nor Laegeforen 2000, 120: 551–555.
33.
go back to reference Stordal E, Bjartveit MK, Dahl NH, Krüger Ø, Mykletun A, Dahl AA: Depression in relation to age and gender in the population: the Nord-Trøndelag Health Study (HUNT). Acta Psychiatr Scand 2001, 104: 210–216. 10.1034/j.1600-0447.2001.00130.xCrossRefPubMed Stordal E, Bjartveit MK, Dahl NH, Krüger Ø, Mykletun A, Dahl AA: Depression in relation to age and gender in the population: the Nord-Trøndelag Health Study (HUNT). Acta Psychiatr Scand 2001, 104: 210–216. 10.1034/j.1600-0447.2001.00130.xCrossRefPubMed
34.
go back to reference Singh SJ, Morgan MD, Scott S, Walters D, Hardman AE: Development of a shuttle walking test of disability in patients with chronic airways obstruction. Thorax 1992, 47: 1019–1024. 10.1136/thx.47.12.1019PubMedCentralCrossRefPubMed Singh SJ, Morgan MD, Scott S, Walters D, Hardman AE: Development of a shuttle walking test of disability in patients with chronic airways obstruction. Thorax 1992, 47: 1019–1024. 10.1136/thx.47.12.1019PubMedCentralCrossRefPubMed
35.
go back to reference Dowson LJ, Newall C, Guest PJ, Hill SL, Stockley RA: Exercise capacity predicts health status in α1-antitrypsin deficiency. Am J Respir Crit Care Med 2001, 163: 936–941.CrossRefPubMed Dowson LJ, Newall C, Guest PJ, Hill SL, Stockley RA: Exercise capacity predicts health status in α1-antitrypsin deficiency. Am J Respir Crit Care Med 2001, 163: 936–941.CrossRefPubMed
36.
go back to reference Ware JE, Snow KK, Konsinski M, Gandek B: Manual and Interpretation Guide: SF-36 Health Survey. Boston: The Health Institute, New England Medical Center; 1997. Ware JE, Snow KK, Konsinski M, Gandek B: Manual and Interpretation Guide: SF-36 Health Survey. Boston: The Health Institute, New England Medical Center; 1997.
37.
go back to reference Ware JE, Konsinski M, Keller SD: SF-36 Physical and Mental Health Summary Scales: A User's Manual. Boston: Health Assessment Lab, New England Medical Center; 1994. Ware JE, Konsinski M, Keller SD: SF-36 Physical and Mental Health Summary Scales: A User's Manual. Boston: Health Assessment Lab, New England Medical Center; 1994.
38.
go back to reference Alonso J, Prieto L, Ferrer M, Vilagut G, Broquetas JM, Roca J, Batlle JS, Antò JM: Testing the measurement properties of the Spanish version of the SF-36 Health Survey among male patients with chronic obstructive pulmonary disease. J Clin Epidemiol 1998, 51: 1087–1094. 10.1016/S0895-4356(98)00100-0CrossRefPubMed Alonso J, Prieto L, Ferrer M, Vilagut G, Broquetas JM, Roca J, Batlle JS, Antò JM: Testing the measurement properties of the Spanish version of the SF-36 Health Survey among male patients with chronic obstructive pulmonary disease. J Clin Epidemiol 1998, 51: 1087–1094. 10.1016/S0895-4356(98)00100-0CrossRefPubMed
39.
go back to reference Harper R, Brazier JE, Waterhouse JC, Walters SJ, Jones NM, Howard P: Comparison of outcome measures for patients with chronic obstructive pulmonary disease (COPD) in an outpatient setting. Thorax 1997, 52: 879–887.PubMedCentralCrossRefPubMed Harper R, Brazier JE, Waterhouse JC, Walters SJ, Jones NM, Howard P: Comparison of outcome measures for patients with chronic obstructive pulmonary disease (COPD) in an outpatient setting. Thorax 1997, 52: 879–887.PubMedCentralCrossRefPubMed
40.
go back to reference Loge JH, Kaasa S, Hjemstad MJ, Kvien TK: Translation and performance of the Norwegian SF-36 health survey in patients with rheumatoid arthritis. I. Data quality, scaling assumptions, reliability and construct validity. J Clin Epidemiol 1998, 51: 1069–1076. 10.1016/S0895-4356(98)00098-5CrossRefPubMed Loge JH, Kaasa S, Hjemstad MJ, Kvien TK: Translation and performance of the Norwegian SF-36 health survey in patients with rheumatoid arthritis. I. Data quality, scaling assumptions, reliability and construct validity. J Clin Epidemiol 1998, 51: 1069–1076. 10.1016/S0895-4356(98)00098-5CrossRefPubMed
41.
42.
go back to reference Osoba D: Translating the science of patient-reported outcomes assessment into clinical practice. J Natl Cancer Inst Monogr 2007, 37: 5–11. 10.1093/jncimonographs/lgm002CrossRefPubMed Osoba D: Translating the science of patient-reported outcomes assessment into clinical practice. J Natl Cancer Inst Monogr 2007, 37: 5–11. 10.1093/jncimonographs/lgm002CrossRefPubMed
43.
go back to reference Di Marco F, Verga M, Reggente M, Casanova FM, Santus P, Blasi F, Allegra L, Centanni S: Anxiety and depression in COPD patients: the roles of gender and disease severity. Respir Med 2006, 100: 1767–1774. 10.1016/j.rmed.2006.01.026CrossRefPubMed Di Marco F, Verga M, Reggente M, Casanova FM, Santus P, Blasi F, Allegra L, Centanni S: Anxiety and depression in COPD patients: the roles of gender and disease severity. Respir Med 2006, 100: 1767–1774. 10.1016/j.rmed.2006.01.026CrossRefPubMed
44.
go back to reference Haave E, Skumlien S, Hyland ME: Gender considerations in pulmonary rehabilitation. Journal of Cardiopulmonary Rehabilitation and Prevention. J Cardiopulm Rehabil Prev 2008, 28(3):215–219.CrossRefPubMed Haave E, Skumlien S, Hyland ME: Gender considerations in pulmonary rehabilitation. Journal of Cardiopulmonary Rehabilitation and Prevention. J Cardiopulm Rehabil Prev 2008, 28(3):215–219.CrossRefPubMed
45.
go back to reference Stavem K, Boe J, Erikssen J: Health status, dyspnea, lung function and exercise capacity in patients with chronic obstructive pulmonary disease. Int J Tuberc Lung Dis 1999, 3(10):920–926.PubMed Stavem K, Boe J, Erikssen J: Health status, dyspnea, lung function and exercise capacity in patients with chronic obstructive pulmonary disease. Int J Tuberc Lung Dis 1999, 3(10):920–926.PubMed
46.
go back to reference Fayers PM, Machin D: Quality of Life. The Assessment, Analysis and Interpretation of Patient-reported Outcomes. West Sussex: Wiley; 2007. Fayers PM, Machin D: Quality of Life. The Assessment, Analysis and Interpretation of Patient-reported Outcomes. West Sussex: Wiley; 2007.
47.
go back to reference McCord M, Cronin-Stubbs D: Operationalizing dyspnea: focus on measurement. Heart Lung 1992, 21(2):167–179.PubMed McCord M, Cronin-Stubbs D: Operationalizing dyspnea: focus on measurement. Heart Lung 1992, 21(2):167–179.PubMed
48.
go back to reference Howell HB, Brawmann-Mintzer O, Monnier J, Yonkers KA: Generalized anxiety disorder in women. Psychiatr Clin North Am 2006, 24: 165–178. 10.1016/S0193-953X(05)70212-4CrossRef Howell HB, Brawmann-Mintzer O, Monnier J, Yonkers KA: Generalized anxiety disorder in women. Psychiatr Clin North Am 2006, 24: 165–178. 10.1016/S0193-953X(05)70212-4CrossRef
49.
go back to reference Munk-Jørgensen P, Allgulander C, Dahl AA, Foldager L, Holm M, Rasmussen I, Virta A, Huuhtanen M-T, Wittchen H-U: Prevalence of generalized anxiety disorder in general practice in Denmark, Finland, Norway, and Sweden. Psychiatr Serv 2006, 57: 1738–1744. 10.1176/appi.ps.57.12.1738CrossRefPubMed Munk-Jørgensen P, Allgulander C, Dahl AA, Foldager L, Holm M, Rasmussen I, Virta A, Huuhtanen M-T, Wittchen H-U: Prevalence of generalized anxiety disorder in general practice in Denmark, Finland, Norway, and Sweden. Psychiatr Serv 2006, 57: 1738–1744. 10.1176/appi.ps.57.12.1738CrossRefPubMed
50.
go back to reference Cully JA, Graham DP, Stanley MA, Ferguson C, Sharafkhaneh AS, Souchek J, Kunik ME: Quality of life in patients with chronic obstructive pulmonary disease and comorbid anxiety and depression. Psychosomatics 2006, 47: 312–319. 10.1176/appi.psy.47.4.312CrossRefPubMed Cully JA, Graham DP, Stanley MA, Ferguson C, Sharafkhaneh AS, Souchek J, Kunik ME: Quality of life in patients with chronic obstructive pulmonary disease and comorbid anxiety and depression. Psychosomatics 2006, 47: 312–319. 10.1176/appi.psy.47.4.312CrossRefPubMed
51.
go back to reference Spencer S, Calverley PMA, Burge SP, Jones PW: Health status deterioration in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001, 163(1):122–128.CrossRefPubMed Spencer S, Calverley PMA, Burge SP, Jones PW: Health status deterioration in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001, 163(1):122–128.CrossRefPubMed
52.
go back to reference Engström CP, Persson LO, Larsson S, Rydèn A, Sullivan M: Functional status and well being in chronic obstructive pulmonary disease with regard to clinical parameters and smoking: a descriptive and comparative study. Thorax 1996, 51: 825–830. 10.1136/thx.51.8.825PubMedCentralCrossRefPubMed Engström CP, Persson LO, Larsson S, Rydèn A, Sullivan M: Functional status and well being in chronic obstructive pulmonary disease with regard to clinical parameters and smoking: a descriptive and comparative study. Thorax 1996, 51: 825–830. 10.1136/thx.51.8.825PubMedCentralCrossRefPubMed
53.
go back to reference Altman DG: Practical statistics for medical research. 1st edition. London: Champmand & Hall/CRC; 1999. Altman DG: Practical statistics for medical research. 1st edition. London: Champmand & Hall/CRC; 1999.
54.
go back to reference Polit DF, Beck CT: Nursing research. Generating and assessing evidence for nursing practice. Eighth edition. UK: Lippincott Williams & Wilkins; 2007. Polit DF, Beck CT: Nursing research. Generating and assessing evidence for nursing practice. Eighth edition. UK: Lippincott Williams & Wilkins; 2007.
55.
go back to reference Ries AL: Pulmonary Rehabilitation and COPD. Seminars in respiratory and criticare Medicine 2005, 26: 133–141. 10.1055/s-2005-869534CrossRef Ries AL: Pulmonary Rehabilitation and COPD. Seminars in respiratory and criticare Medicine 2005, 26: 133–141. 10.1055/s-2005-869534CrossRef
56.
go back to reference Pauwels RA, Rabe KF: Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet 2004, 364: 613–620. 10.1016/S0140-6736(04)16855-4CrossRefPubMed Pauwels RA, Rabe KF: Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet 2004, 364: 613–620. 10.1016/S0140-6736(04)16855-4CrossRefPubMed
Metadata
Title
What determines subjective health status in patients with chronic obstructive pulmonary disease: importance of symptoms in subjective health status of COPD patients
Authors
Signe Berit Bentsen
Anne Hildur Henriksen
Tore Wentzel-Larsen
Berit Rokne Hanestad
Astrid Klopstad Wahl
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2008
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-6-115

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