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BMC Gastroenterology
Published in: BMC Gastroenterology 1/2011

Open Access 01-12-2011 | Research article

Association between RUNX3 promoter methylation and gastric cancer: a meta-analysis

Authors: Xiao-yuan Fan, Xin-lei Hu, Tie-mei Han, Na-na Wang, Yi-miao Zhu, Wen Hu, Zhen-hua Ma, Chen-jing Zhang, Xiang Xu, Zai-yuan Ye, Chun-mao Han, Wen-sheng Pan

Published in: BMC Gastroenterology | Issue 1/2011

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Abstract

Background

Runt-related transcription factor 3 (RUNX3) is a member of the runt-domain family of transcription factors and has been reported to be a candidate tumor suppressor in gastric cancer. However, the association between RUNX3 promoter methylation and gastric cancer remains unclear.

Methods

We systematically reviewed studies of RUNX3 promoter methylation and gastric cancer published in English or Chinese from January 2000 to January 2011, and quantified the association between RUNX3 promoter methylation and gastric cancer using meta-analysis methods.

Results

A total of 1740 samples in 974 participants from seventeen studies were included in the meta-analysis. A significant association was observed between RUNX3 promoter methylation and gastric cancer, with an aggregated odds ratio (OR) of 5.63 (95%CI 3.15, 10.07). There was obvious heterogeneity among studies. Subgroup analyses (including by tissue origin, country and age), meta-regression were performed to determine the source of the heterogeneity. Meta-regression showed that the trend in ORs was inversely correlated with age. No publication bias was detected. The ORs for RUNX3 methylation in well-differentiated vs undifferentiated gastric cancers, and in intestinal-type vs diffuse-type carcinomas were 0.59 (95%CI: 0.30, 1.16) and 2.62 (95%CI: 1.33, 5.14), respectively. There were no significant differences in RUNX3 methylation in cancer tissues in relation to age, gender, TNM stage, invasion of tumors into blood vessel or lymphatic ducts, or tumor stage.

Conclusions

This meta-analysis identified a strong association between methylation of the RUNX3 promoter and gastric cancer, confirming the role of RUNX3 as a tumor suppressor gene.
Appendix
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Metadata
Title
Association between RUNX3 promoter methylation and gastric cancer: a meta-analysis
Authors
Xiao-yuan Fan
Xin-lei Hu
Tie-mei Han
Na-na Wang
Yi-miao Zhu
Wen Hu
Zhen-hua Ma
Chen-jing Zhang
Xiang Xu
Zai-yuan Ye
Chun-mao Han
Wen-sheng Pan
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2011
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/1471-230X-11-92

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