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BMC Cardiovascular Disorders
Published in: BMC Cardiovascular Disorders 1/2011

Open Access 01-12-2011 | Research article

The higher exercise intensity and the presence of allele I of ACE gene elicit a higher post-exercise blood pressure reduction and nitric oxide release in elderly women: an experimental study

Authors: Hugo AP Santana, Sérgio R Moreira, Willson B Neto, Carla B Silva, Marcelo M Sales, Vanessa N Oliveira, Ricardo Y Asano, Foued S Espíndola, Otávio T Nóbrega, Carmen SG Campbell, Herbert G Simões

Published in: BMC Cardiovascular Disorders | Issue 1/2011

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Abstract

Background

The absence of the I allele of the angiotensin converting enzyme (ACE) gene has been associated with higher levels of circulating ACE, lower nitric oxide (NO) release and hypertension. The purposes of this study were to analyze the post-exercise salivary nitrite (NO2 -) and blood pressure (BP) responses to different exercise intensities in elderly women divided according to their ACE genotype.

Methods

Participants (n = 30; II/ID = 20 and DD = 10) underwent three experimental sessions: incremental test - IT (15 watts workload increase/3 min) until exhaustion; 20 min exercise 90% anaerobic threshold (90% AT); and 20 min control session without exercise. Volunteers had their BP and NO2 - measured before and after experimental sessions.

Results

Despite both intensities showed protective effect on preventing the increase of BP during post-exercise recovery compared to control, post-exercise hypotension and increased NO2 - release was observed only for carriers of the I allele (p < 0.05).

Conclusion

Genotypes of the ACE gene may exert a role in post-exercise NO release and BP response.
Appendix
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Metadata
Title
The higher exercise intensity and the presence of allele I of ACE gene elicit a higher post-exercise blood pressure reduction and nitric oxide release in elderly women: an experimental study
Authors
Hugo AP Santana
Sérgio R Moreira
Willson B Neto
Carla B Silva
Marcelo M Sales
Vanessa N Oliveira
Ricardo Y Asano
Foued S Espíndola
Otávio T Nóbrega
Carmen SG Campbell
Herbert G Simões
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Cardiovascular Disorders / Issue 1/2011
Electronic ISSN: 1471-2261
DOI
https://doi.org/10.1186/1471-2261-11-71

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